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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Glutamate receptor, ionotropic, delta 1

GRID1, glutamate receptor ionotropic delta 1, GluRdelta, glutamate receptor, ionotropic, delta 1
This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: HAD, ACID, delta1, KA1, V1a
Papers on GRID1
Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study.
Braff et al., San Diego, United States. In Schizophr Res, Jan 2016
Genotyping via a custom array of 1536 SNPs from 94 candidate genes identified associations for CTNNA2, ERBB4, GRID1, GRID2, GRIK3, GRIK4, GRIN2B, NOS1AP, NRG1, and RELN across multiple endophenotypes.
CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers.
Liu et al., Albuquerque, United States. In Hum Brain Mapp, Aug 2015
The genetic factor highlighted the CREB and BDNF references, as well as other genes including GRM5, GRM7, GRID1, GRIN2A, PRKCA, and PRKCB.
GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells.
Meloni et al., Siena, Italy. In Eur J Hum Genet, Feb 2015
The only major change in gene expression common to MECP2- and CDKL5-mutated cells was for GRID1, encoding for glutamate D1 receptor (GluD1), a member of the δ-family of ionotropic glutamate receptors.
LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage.
Chun et al., Los Angeles, United States. In Transl Psychiatry, 2014
In addition, both prenatal serum and LPA exposure altered the expression of many genes and pathways related to schizophrenia, including the expression of Grin2b, Slc17a7 and Grid1.
Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study.
Saleheen et al., Malmö, Sweden. In Bmc Med Genet, 2014
We observed nominal evidence of interactions of CLIP1 rs11583200 (P interaction = 0.014), CADM2 rs13078960 (P interaction = 0.037) and GALNT10 rs7715256 (P interaction = 0.048) with physical activity, and PTBP2 rs11165643 (P interaction = 0.045), HIP1 rs1167827 (P interaction = 0.015), C6orf106 rs205262 (P interaction = 0.032) and GRID1 rs7899106 (P interaction = 0.043) with smoking on BMI.
Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population.
Xu et al., Xi'an, China. In Bmc Gastroenterol, 2014
The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colorectal cancers in the Chinese Han population.
Population history and genomic signatures for high-altitude adaptation in Tibetan pigs.
Ren et al., Nanchang, China. In Bmc Genomics, 2013
These genes, such as PLA2G12A, RGCC, C9ORF3, GRIN2B, GRID1 and EPAS1, are involved in high-altitude physiology including angiogenesis, pulmonary hypertension, oxygen intake, defense response and erythropoiesis.
Glutamate receptor δ 1 (GRID1) genetic variation and brain structure in schizophrenia.
Schlösser et al., Jena, Germany. In J Psychiatr Res, 2012
Common genetic variation in the promoter region of the glutamate receptor delta 1 (GRID1) gene has recently been shown to confer increased risk for schizophrenia in several independent large samples.
Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways.
Pericak-Vance et al., Miami, United States. In Hum Mol Genet, 2012
These genes include glutamate receptors (GRID1, GRIK2 and GRIK4), synaptic regulators (NRXN3, SLC6A8 and SYN3), transcription factor (ZNF804A) and RNA-binding protein FMR1.
Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes.
Mishina et al., Tokyo, Japan. In J Neurochem, 2012
GluRdelta1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with pre-synaptic neurexins containing splice segment 4 through Cbln subtypes.
Truncation of MIMT1 gene in the PEG3 domain leads to major changes in placental gene expression and stillbirth in cattle.
Schnieke et al., Freising, Germany. In Biol Reprod, 2012
Gene expression microarray analyses identified increased NPSR1A, IL1RN, NOS3, IL4R, ZDHHC22, and SMOC2 expression in fetuses carrying the deletion and decreased GRID1, PLG, and IGF1 expression.
Genome-wide association study of comorbid depressive syndrome and alcohol dependence.
Dick et al., Richmond, United States. In Psychiatr Genet, 2012
Genes that have been previously associated with depression, AD, or other addiction-related phenotypes - such as CDH13, CSMD2, GRID1, and HTR1B - were implicated by nominally significant SNPs.
The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.
Bebok et al., Birmingham, United States. In J Biol Chem, 2012
miR-346 is encoded within an intron of the glutamate receptor ionotropic delta-1 gene (GRID1), but its ER stress-associated expression is independent of GRID1.
Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors.
Dravid et al., Omaha, United States. In Plos One, 2011
Deletion of GluD1 leads to aberrant circuitry in prefrontal cortex and amygdala. Furthermore, these findings are in agreement with the human genetic studies suggesting a strong association of GRID1 gene with several neuropsychiatric disorders.
The phenotype of recurrent 10q22q23 deletions and duplications.
de Vries et al., Nijmegen, Netherlands. In Eur J Hum Genet, 2011
For cardiac defects, BMPR1A and GRID1 are putative candidate genes because of their association with cardiac structure and function.
Mutations in the transmembrane domain M3 generate spontaneously open orphan glutamate δ1 receptor.
Dravid et al., Omaha, United States. In Brain Res, 2011
The residues in the highly conserved SYTANLAAF region form the activation gate for GluRdelta1, since mutations in a set of closely arranged residues are found to generate spontaneously open channels.
Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter.
Rietschel et al., Mannheim, Germany. In Schizophr Res, 2009
The results of this study suggested that genetic variants in the GRID1 transcriptional regulatory region may play a role in the etiology of schizophrenia.
A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population.
He et al., Shanghai, China. In Schizophr Res, 2007
results strongly support previously reported association studies, implicating GRID1 in the etiology of schizophrenia
Cerebellar regulation mechanisms learned from studies on GluRdelta2.
Hirano, Kyoto, Japan. In Mol Neurobiol, 2006
Several ataxic spontaneous mutant mice have defects in the GluRdelta gene.
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