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GRIP1 associated protein 1

GRASP-1, GRIP-associated protein-1
a neuronal rasGEF that may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, ACID, Rab4, Rab11, PrP
Papers using GRASP-1 antibodies
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.
Ehlers Michael D., In PLoS Biology, 2006
... GRASP-1 shRNA#5 (GTCCCAGCACAAAGAAGAA) was designed by using the siRNA selection program at the Whitehead Institute for Biomedical Research ...
Emerging roles for ubiquitin and protein degradation in neuronal function
Schuman Erin M. et al., In Frontiers in Molecular Neuroscience, 2006
... (St Louis, MO, USA); KCMF1 (15-288-21213) from Genway (San Diego, CA, USA); drebrin (ab12350) and GRASP-1 (ab30576) from Abcam (Cambridge, MA, USA) ...
Papers on GRASP-1
Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation.
Newell et al., Wollongong, Australia. In Acta Neuropathol, Jul 2015
We assessed mGluR5 mRNA and protein levels in the dorsolateral prefrontal cortex (DLPFC) using a large cohort of schizophrenia and control subjects (n = 37/group), and additionally measured protein levels of recently discovered mGluR5 endogenous regulators, Norbin (neurochondrin), Tamalin (GRASP-1), and Preso1 (FRMPD4), which regulate mGluR5 localization, internalization and signaling.
Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund's adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats.
Lin et al., Taipei, Taiwan. In Pain, 2012
We examined whether the phosphorylation of spinal serum- and glucocorticoid-inducible kinase 1 (SGK1) and downstream glutamate receptor interacting protein (GRIP)-associated protein-1 (GRASP-1)/Rab4-dependent GluR1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) recycling play a role in inflammatory pain.
Autoantibodies to GW bodies and other autoantigens in primary biliary cirrhosis.
Fritzler et al., Calgary, Canada. In Clin Exp Immunol, 2011
Autoantibodies to mitochondrial antigen-pyruvate dehydrogenase complex (M2), branched-chain 2-oxo-acid dehydrogenase complex and 2-oxo glutarate dehydrogenase complex (3E-BPO), gp210, sp100, promyelocytic leukaemia cell antigen (PML) and liver kidney microsomal-1 antigen (LKM-1) were detected by a line immunoassay and antibodies to GWB (GW182, RAP55, Ge-1, GW2, GW3) and glutamate receptor interacting protein (GRIP)-associated protein-1 (GRASP-1), by an addressable laser bead immunoassay (ALBIA).
Prenatal cocaine exposure increases synaptic localization of a neuronal RasGEF, GRASP-1 via hyperphosphorylation of AMPAR anchoring protein, GRIP.
Wang et al., New York City, United States. In Plos One, 2010
Because overexpression of GRIP-associated neuronal rasGEF protein (GRASP-1) specifically reduces the synaptic targeting of AMPARs, we hypothesized that prenatal cocaine exposure enhances GRASP-1 synaptic membrane localization leading to hyper-activation of ras family proteins and heightened actin polymerization.
GRASP-1 regulates endocytic receptor recycling and synaptic plasticity.
van der Sluijs et al., Rotterdam, Netherlands. In Commun Integr Biol, 2010
In a recent paper we discovered that the coiled-coil protein GRIP-associated protein-1 (GRASP-1) is a neuron-specific effector of the small GTPase Rab4 and key component of AMPA receptor recycling machinery in dendrites.1 GRASP-1 is essential for maintenance of spine morphology and important for LTP.
Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes.
van der Sluijs et al., Rotterdam, Netherlands. In Plos Biol, 2010
Here, we identify GRIP-associated protein-1 (GRASP-1) as a neuron-specific effector of Rab4 and key component of the molecular machinery that coordinates recycling endosome maturation in dendrites.
GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway.
Huganir et al., Baltimore, United States. In Febs Lett, 2007
Results suggest that GRASP-1 serves as a scaffold protein to facilitate MEKK-1 activation of JNK signaling in neurons.
Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes.
Fritzler et al., Calgary, Canada. In Clin Immunol, 2005
GRASP-1 was identified as an soluble autoantigen that has numerous coiled-coil domains throughout the protein.
PDZ7 of glutamate receptor interacting protein binds to its target via a novel hydrophobic surface area.
Zhang et al., Hong Kong, Hong Kong. In J Biol Chem, 2002
The interaction between GRIP1 PDZ7 and a Ras guanine nucleotide exchange factor, GRASP-1, regulates synaptic distribution of AMPA receptors.
Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody.
Huganir et al., Baltimore, United States. In Neuroscience, 2001
GRASP-1 is a recently identified neuronal substrate of caspase-3-subfamily caspases.
GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex.
Huganir et al., Baltimore, United States. In Neuron, 2000
GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo.
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