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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Granzyme K

granzyme K, GzmK, granzyme 3
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Perforin, CAN, CD8, tryptase, PrP
Papers using granzyme K antibodies
Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis.
Sozzani Silvano, In PLoS ONE, 2008
... Granzyme K was obtained from Axxora (Burlington, ON Canada), and ...
Papers on granzyme K
Phenotype of NK Cells Determined on the Basis of Selected Immunological Parameters in Children Treated due to Acute Lymphoblastic Leukemia.
Grzesk et al., Toruń, Poland. In Medicine (baltimore), Dec 2015
Also, there was a significantly higher fraction of NK cells expressing granzyme K in patients who completed the therapy.Abnormalities of NK cells were found at all stages of the treatment; however, the most pronounced changes were found at the end of intensive chemotherapy.
Effect of carbamate pesticides on perforin, granzymes A-B-3/K, and granulysin in human natural killer cells.
Kawada et al., Tokyo, Japan. In Int J Immunopathol Pharmacol, Sep 2015
We previously found that ziram, a carbamate pesticide, significantly reduced perforin, granzyme A (GrA), granzyme B (GrB), granzyme 3/K (Gr3/K), and granulysin (GRN) levels in NK-92MI cells, a human natural killer (NK) cell line.
Increased intra- and extracellular granzyme expression in patients with tuberculosis.
van der Poll et al., Amsterdam, Netherlands. In Tuberculosis (edinb), Sep 2015
GzmK expression was not altered in TB patients in any lymphocyte subset.
Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells.
Risma et al., Madison, United States. In Blood, Sep 2015
In addition to the previously described aspartase-cleavable biosensors, we report development of granzyme A and granzyme K biosensors, for which no other functional reporters are available.
Identification of differentially expressed proteins of brain tissue in response to methamidophos in flounder (Paralichthys olivaceus).
Huang et al., Xiamen, China. In Fish Shellfish Immunol, Jun 2015
According to our results and analyzing, heat shock protein 90 (HSP90) and granzyme K (GzmK) had taken important part in immune response to MAP-stress and could be biomarkers for MAP-stress in flounder.
Prognostic and predictive value of NanoString-based immune-related gene signatures in a neoadjuvant setting of triple-negative breast cancer: relationship to tumor-infiltrating lymphocytes.
Gong et al., Seoul, South Korea. In Breast Cancer Res Treat, Jun 2015
Higher expression of NFKB1, MAPK1, TRAF1, CXCL13, GZMK, and IL7R was significantly associated with pCR, higher Miller-Payne grade, and lower residual cancer burden class.
Increased expression of perforin, granzyme B, and C5b-9 in villitis of unknown etiology.
Hata et al., Tokyo, Japan. In Placenta, May 2015
METHODS: Six placentas with VUE and 3 control placentas were stained using immunohistochemistry with antibodies for CD3, CD4, CD8, CD68, CD163, perforin, granzyme B, granzyme K, and C5b-9.
HLA-A02:01-restricted epitopes identified from the herpes simplex virus tegument protein VP11/12 preferentially recall polyfunctional effector memory CD8+ T cells from seropositive asymptomatic individuals and protect humanized HLA-A*02:01 transgenic mice against ocular herpes.
BenMohamed et al., Irvine, United States. In J Immunol, Apr 2015
In 10 sequentially studied HLA-A*02:01-positive and HSV-1-seropositive ASYMP individuals, the most frequent, robust, and polyfunctional effector CD8(+) T cell responses, as assessed by a combination of tetramer frequency, granzyme B, granzyme K, perforin, CD107(a/b) cytotoxic degranulation, IFN-γ, and multiplex cytokines assays, were predominantly directed against three epitopes: VP11/1266-74, VP11/12220-228, and VP11/12702-710.
Bursal transcriptome of chickens protected by DNA vaccination versus those challenged with infectious bursal disease virus.
Lin et al., West Lafayette, United States. In Arch Virol, 2015
The expression levels of granzyme K and CD8 in DNA-vaccinated chickens were significantly (p < 0.05) higher than those in unvaccinated chickens upon IBDV challenge at 0.5 or 1 dpc.
Substrate specificities of the granzyme tryptases A and K.
Van Damme et al., Gent, Belgium. In J Proteome Res, 2015
In addition, the so far uncharacterized mouse granzyme K was profiled alongside its human orthologue.
Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin.
Shoemaker et al., Charleston, United States. In Bmc Med Genomics, 2014
Several genes identified by microarray are important in wound healing (CD9, CD36, vWF and Factor XIII), adaptive immunity (HLA-DQB1, DQB2, IL18R1 and IL5RA) and innate immunity (GZMK, TOLLIP, SIGIRR and VIPR2), overlapping several areas shown to be disrupted in a mouse model of acute exposure to ciguatoxin.
Yeast Endoplasmic Reticulum Sequestration Screening for the Engineering of Proteases from Libraries Expressed in Yeast.
Iverson et al., Austin, United States. In Methods Mol Biol, 2014
In addition, the generality of this method is also validated by other proteases such as human granzyme K and the hepatitis C virus protease, and the human Abelson tyrosine kinase.
Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature.
Kaiserman et al., In Biol Chem, 2014
We identified a primordial GASPID gene as either GzmA or GzmK in cartilaginous fish and reconstructed an evolutionary path through to humans.
Substrate specificity of human granzyme 3: analyses of the P3-P2-P1 triplet using fluorescence resonance energy transfer substrate libraries.
Kawada et al., Japan. In Biosci Trends, 2014
Granzyme 3 (Gr3) is known as a tryptase-type member of the granzyme family and exists in the granules of immunocompetent cells.
Fluorescently activated cell sorting followed by microarray profiling of helper T cell subtypes from human peripheral blood.
Tomita et al., Sendai, Japan. In Plos One, 2013
Moreover, our data suggest that GZMK, GZMH, EOMES, IGFBP3, and STOM may be novel markers for distinguishing Th1 cells from Th2 cells, whereas IL17RB and CNTNAP1 can be Th2-specific markers.
Unexpected role for granzyme K in CD56bright NK cell-mediated immunoregulation of multiple sclerosis.
Bielekova et al., Bethesda, United States. In J Immunol, 2011
Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56(bright) natural killer (NK) cells toward activated T cells.
Recombinant human progranzyme 3 expressed in Escherichia coli for analysis of its activation mechanism.
Kawada et al., Tokyo, Japan. In Microbiol Immunol, 2010
Gr3 proenzymes is activated by cathepsin C which concomitantly decreased the molecular weight to that of active Gr3.
Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis.
Fan et al., Beijing, China. In J Immunol, 2009
p53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy.
Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A.
Kummer et al., Utrecht, Netherlands. In J Biol Chem, 2009
GrK not only constitutes a redundant functional backup mechanism that assists GrA-induced cell death but that it also displays a unique function by cleaving its own specific substrates.
Altered levels and molecular forms of granzyme k in plasma from septic patients.
Lim et al., East Providence, United States. In Shock, 2007
Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis.
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