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Glutathione peroxidase 2

GPX2, GPRP, gastrointestinal glutathione peroxidase, glutathione peroxidase 2, GI-GPx
This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: gpx1, CAN, ACID, Origin Recognition Complex, HAD
Papers using GPX2 antibodies
The expression and the functional roles of tissue factor and protease-activated receptor-2 on SW620 cells
McCarty Owen J. T. et al., In Frontiers in Oncology, 2007
... H-Gly-Pro-Arg-Pro-OH (GPRP) was purchased from Calbiochem.Fluorescent probes and reagentsFluorescein isothiocyante (FITC)-conjugated TF monoclonal antibody was purchased from LifeSpan Bioscences ...
Papers on GPX2
Chemopreventive Properties of Genipin on AGS Cell Line via Induction of JNK/Nrf2/ARE Signaling Pathway.
Chang et al., Seoul, South Korea. In J Biochem Mol Toxicol, Jan 2016
Furthermore, immunofluorescence analysis and Western blotting were used to demonstrate that genipin treatment resulted in the upregulation and nuclear translocation of Nrf2, as well as upregulation of gastrointestinal glutathione peroxidase.
Effect of Inorganic Dietary Selenium Supplementation on Selenoprotein and Lipid Metabolism Gene Expression Patterns in Liver and Loin Muscle of Growing Lambs.
Pierzchała et al., Poland. In Biol Trace Elem Res, Jan 2016
Significant differences were found in the expression of GPX1, GPX2, SEPM, SEPW1, SEP15, SEPGS2, and TXNRD1 in the liver, and GPX1, SEPP1, SEPN1, SEPW1, SEP15, and MSRB1 in the LD muscle between S and C lambs.
A novel strain of Lactobacillus mucosae isolated from a Gaotian villager improves in vitro and in vivo antioxidant as well as biological properties in d-galactose-induced aging mice.
Wei et al., Nanchang, China. In J Dairy Sci, Jan 2016
Regarding mRNA expression level detected quantitatively by real-time PCR, we observed that L. mucosae LMU1001 significantly upregulated antioxidant genes (i.e., MT1A and MT1M in HT-29 and Caco-2) and those genes (i.e., MT1, MT2, GPx1, and GPx2) in the intestinal tract of the model mice.
Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells.
Steinbrenner et al., Düsseldorf, Germany. In Free Radic Biol Med, Jan 2016
Conversely, transcription of the selenoenzymes glutathione peroxidase 2 (GPx2) and thioredoxin reductase 1 (TrxR1) is up-regulated upon Nrf2 activation.
Targeting the expression of glutathione- and sulfate-dependent detoxification enzymes in HepG2 cells by oxygen in minimal and amino acid enriched medium.
Barańczyk-Kuźma et al., Warsaw, Poland. In Exp Mol Pathol, Dec 2015
The result indicated that the expression of glutathione-dependent enzymes (GSTA, M, P, and GPX2) was sensitive to oxygen and medium type.
Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver.
Bosch et al., Leipzig, Germany. In Mol Biol Evol, Dec 2015
Six of these exceeded the false discovery rate cutoff and were related to essential trace elements: 1) one pQTL for GPX2 (rs10133290); 2) two previously described eQTLs for HFE (rs12346) and SELO (rs4838862) expression; and 3) three nutriQTLs: The pathogenic C282Y mutation at HFE affecting iron (rs1800562), and two SNPs within several clustered metallothionein genes determining selenium concentration (rs1811322 and rs904773).
Gene-specific regulation of hepatic selenoprotein expression by interleukin-6.
Schomburg et al., Berlin, Germany. In Metallomics, Dec 2015
The effects of IL-6 on glutathione peroxidase (GPX) expression were isozyme-specific; GPX1 remained unaffected, while transcript concentrations of GPX2 increased and those of GPX4 decreased.
GABA selectively increases mucin-1 expression in isolated pig jejunum.
Deiner et al., Berlin, Germany. In Genes Nutr, Nov 2015
Porcine jejunum epithelial preparations were incubated with two different amounts of GABA or glutamine on the mucosal side for 4 h, and changes in the relative gene expression of seven different mucins, enzymes involved in mucin shedding, GABA B receptor, enzymes involved in glutamine/GABA metabolism, glutathione peroxidase 2, and interleukin 10 were examined by quantitative PCR (TaqMan(®) assays).
Selenium Deficiency Affects the mRNA Expression of Inflammatory Factors and Selenoprotein Genes in the Kidneys of Broiler Chicks.
Shan et al., Harbin, China. In Biol Trace Elem Res, Oct 2015
The mRNA levels of 14 selenoprotein genes (Dio1, Dio2, GPx3, Sepp1, SelH, SelI, SelK, Sepn1, SelO, SelW, Sep15, SelT, SelU, and SelS) decreased, and 9 selenoprotein genes (GPx1, GPx2, GPx4, SelPb, Txnrd1, Txnrd2, Txnrd3, SPS2, and SelM) increased in L group (p < 0.05), but the Dio3 and Sepx1 mRNA levels did not change.
Significance of Polymorphisms and Expression of Enzyme-Encoding Genes Related to Glutathione in Hematopoietic Cancers and Solid Tumors.
Filip et al., Lublin, Poland. In Biomed Res Int, 2014
The changes in activity of GPX1, GPX2, and GPX3 isoforms may be associated with the development of cancers, for example, prostate cancer or even colon cancer.
Clinical relevance of thyroid cell models in redox research.
Laukkanen et al., Napoli, Italy. In Cancer Cell Int, 2014
RESULTS: Based on the current results, rat thyroid PC Cl3, PC PTC1, PC E1A, or FRLT5 cell models can be used to study NOX2, NOX4, SOD2, SOD3, CATALASE, GPX1, GPX2, GPX5, PRDX2, and PRDX3 gene expression and function.
Glutathione peroxidases.
Maiorino et al., Germany. In Biochim Biophys Acta, 2013
MAJOR CONCLUSIONS: GPxs are involved in balancing the H2O2 homeostasis in signalling cascades, e.g. in the insulin signalling pathway by GPx1; GPx2 plays a dual role in carcinogenesis depending on the mode of initiation and cancer stage; GPx3 is membrane associated possibly explaining a peroxidatic function despite low plasma concentrations of GSH; GPx4 has novel roles in the regulation of apoptosis and, together with GPx5, in male fertility.
Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis.
Kipp et al., Potsdam, Germany. In Ann N Y Acad Sci, 2012
A GPx2-independent decrease in tumor development by selenium (Se) and detrimental effects of the Nrf2-activator sulforaphane in moderate Se deficiency.
Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention.
Belshaw et al., Norwich, United Kingdom. In Proc Nutr Soc, 2012
Based on this review it may be concluded that an understanding of the impact of ITC and Se on aberrant DNA methylation in relation to factors modulating gene-specific and global methylation patterns, in addition to the effect of these food constituents as modulators of key selenoenzymes, such as gastrointestinal glutathione peroxidase-2 (GPx2) and thioredoxin reductase-1 (TrxR1), may provide insights into the potential synergy among various components of a plant-based diet that may counteract the genetic and epigenetic alterations that initiate and sustain neoplasia.
Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply.
Brigelius-Flohé et al., Potsdam, Germany. In Carcinogenesis, 2012
it is concluded that GPx2, although supporting tumor growth, inhibits inflammation-mediated tumorigenesis, but the protective effect of selenium does not strictly depend on GPx2 expression
Glutathione peroxidase 2 in Saccharomyces cerevisiae is distributed in mitochondria and involved in sporulation.
Inoue et al., Uji, Japan. In Biochem Biophys Res Commun, 2011
Gpx2 was found to exist in the cytoplasm and mitochondria.
Differential expression of gastrointestinal glutathione peroxidase (GI-GPx) gene during mouse organogenesis.
Nam et al., Ch'ŏngju, South Korea. In Anat Histol Embryol, 2011
study indicates GI-GPx is spatiotemporally expressed in embryonic organs during organogenesis and may also perform a mutual compensatory role with cGPx in protecting embryos and extraembryonic tissues against reactive oxygen species
Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase.
Chu et al., Duarte, United States. In Inflamm Bowel Dis, 2010
Loss of Gpx2 is associated with diet induced severe colitis.
Glutathione peroxidases in different stages of carcinogenesis.
Kipp et al., Potsdam, Germany. In Biochim Biophys Acta, 2009
GPx2 is up-regulated in cancer cells.
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