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Glycoprotein VI

GPVI, GP6, platelet collagen receptor, platelet glycoprotein VI, GPIV
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: CD45, Gp, CAN, V1a, HAD
Papers on GPVI
Heat shock protein 70 (Hsp70) regulates platelet integrin activation, granule secretion and aggregation.
Aslan et al., Oregon, United States. In Am J Physiol Cell Physiol, Feb 2016
Inhibition of platelet Hsp70 blocked platelet aggregation and granule secretion in response to collagen-related peptide (CRP), which engages the ITAM-bearing collagen receptor GPVI/FcRγ complex.
Lysyl oxidase is associated with increased thrombosis and platelet reactivity.
Ravid et al., Boston, United States. In Blood, Feb 2016
Platelet activation in response to the ligand for collagen receptor GPVI, CRP-XL, was unaffected.
Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development.
Bergmeier et al., Chapel Hill, United States. In J Thromb Haemost, Feb 2016
Murine platelets express two ITAM-containing receptors: the Fc receptor γ-chain (FcRγ), which functionally associates with the collagen receptor GPVI, and the C-type lectin-like 2 (CLEC-2) receptor, a hemITAM receptor for the mucin-type glycoprotein podoplanin.
Antiviral Indolosesquiterpenoid Xiamycins C-E from a Halophilic Actinomycete.
Oh et al., Seoul, South Korea. In J Nat Prod, Jan 2016
Quantitative real-time PCR data revealed the inhibitory effect of 2 on genes encoding essential structural proteins (GP6 nucleocapsid, GP2 spike, and GP5 membrane) for PEDV replication in a dose-dependent manner.
Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners.
Muramatsu, Nagoya, Japan. In J Biochem, Jan 2016
Basigin has isoforms; the common form (basigin or basigin-2) has 2 immunoglobulin domains, and the extended form (basigin-1) has 3. Basigin is the receptor for cyclophilins, S100A9, and platelet GPVI, while basigin-1 serves as the receptor for the rod-derived cone viability factor.
PKCs in thrombus formation.
Kojok et al., Montréal, Canada. In Pathol Biol (paris), Dec 2015
In addition, PKCβ by interacting with its receptor RACK1 has been implicated in the primary phases of signaling via the αIIbβ3 and finally PKCɛ appears to be involved in platelet function downstream GPVI.
Molecular diagnosis and phylogenetic analysis of human papillomavirus type-16 from suspected patients in Pakistan.
Hyder et al., Islamabad, Pakistan. In Infect Agent Cancer, Dec 2015
The samples were tested through Polymerase Chain Reaction (PCR) using already reported primers MY09/MY11, GP5/GP6, GP5+/GP6+, CP65/CP70, CP66/CP69 and SPF1/SPF2 and with those developed in this study including HRT1 and HRT2 primer sets for typing HPV types and HACTB primer set for human beta actin gene as internal positive control.
Genetics of Venous Thrombosis: update in 2015.
Trégouët et al., Marseille, France. In Thromb Haemost, Dec 2015
To date, 17 genes have been robustly demonstrated to harbour genetic variations associated with VT risk: ABO, F2, F5, F9, F11, FGG, GP6, KNG1, PROC, PROCR, PROS1, SERPINC1, SLC44A2, STXBP5, THBD, TSPAN15 and VWF.
The platelet Fc receptor, FcγRIIa.
Gardiner et al., Melbourne, Australia. In Immunol Rev, Nov 2015
Finally, we present some new data investigating whether levels of the extracellular ligand-binding region of platelet glycoprotein VI which is rapidly shed upon engagement of platelet FcγRIIa by autoantibodies, can report on the presence of pathological anti-heparin/platelet factor 4 immune complexes and thus identify patients with pathological autoantibodies who are at the greatest risk of developing life-threatening thrombosis in the setting of heparin-induced thrombocytopenia.
[Study of exogenous carbon monoxide-releasing molecules 2 on endotoxin/lipopolysaccharide-induced abnormal activation of platelets of healthy human donors].
Sun et al., Zhenjiang, China. In Zhonghua Shao Shang Za Zhi, Oct 2015
The expressions of platelet glycoprotein I bα (GPIbα) and GPVI were analyzed by flow cytometer.
Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood.
Farndale et al., Cambridge, United Kingdom. In J Biol Chem, 2012
The GPVI-specific agonist collagen-related peptide or thrombin further increases the number of dimers, thereby providing a feedback mechanism for reinforcing binding to collagen and platelet activation.
Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels.
Gardiner et al., Melbourne, Australia. In Blood, 2012
Exposure of platelets to high shear induced a metalloproteinase-dependent GPVI cleavage, producing a ~55-kDa soluble ectodomain fragment & A ~10-kDa platelet-associated tail fragment. This may down-regulate GPVI expression.
A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents.
Jandrot-Perrus et al., Strasbourg, France. In J Pharmacol Exp Ther, 2012
A preclinical tool (human GPVI as an antiplatelet target) is developed in a genetically modified mouse strain to evaluate the role of GPVI in various models of thrombosis.
Focusing on plasma glycoprotein VI.
Andrews et al., Melbourne, Australia. In Thromb Haemost, 2012
analysis of platelet GPVI, a unique platelet-specific receptor with uses in diagnosis and/or disease prevention [review]
Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity.
Jandrot-Perrus et al., Paris, France. In Arterioscler Thromb Vasc Biol, 2012
The rapid assembly of highly competent dimers of GPVI at sites of vascular lesion represents an important step in the sequence of events leading to platelet activation by collagen.
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
Becker et al., Framingham, United States. In Nat Genet, 2010
We identified associations of seven loci with platelet aggregation near or within GP6 (P=4.6x10(-13)),
Gene variants associated with deep vein thrombosis.
Rosendaal et al., Leiden, Netherlands. In Jama, 2008
false discovery rate < or =.10): rs13146272 in CYP4V2 (risk allele frequency, 0.64), rs2227589 in SERPINC1 (risk allele frequency, 0.10), and rs1613662 in GP6 (risk allele frequency, 0.84).
Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors.
Wucherpfennig et al., Boston, United States. In Immunity, 2005
We examined assembly of four receptors with diverse function: the NK receptors KIR2DS and NKG2C/CD94, the Fc receptor for IgA, and the GPVI collagen receptor.
PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes.
Furie et al., Boston, United States. In Cell, 1989
This interaction is inhibited by anti-PADGEM antibodies, PADGEM, and EDTA; anti-GPIIb-IIIa, anti-thrombospondin, anti-GPIV, and thrombospondin produce no effect.
Identification of a platelet membrane glycoprotein as a falciparum malaria sequestration receptor.
Chulay et al., Washington, D.C., United States. In Science, 1989
CD36 was purified from platelets, where it is known as GPIV, and was shown to be a receptor for binding of infected erythrocytes.
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