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Lysophosphatidic acid receptor 5

GPR92, LPA5, GPR93, Lpar5
This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: ACID, LpA-I, LPA4, V1a, GPCR
Papers on GPR92
LPA signaling is required for dopaminergic neuron development and is reduced through low expression of the LPA1 receptor in a 6-OHDA lesion model of Parkinson's disease.
Ding et al., Weifang, China. In Neurol Sci, Nov 2015
Lysophosphatidic acid (LPA) is a bioactive phospholipid that activates at least five known G-protein-coupled receptors (GPCRs): LPA1-LPA5.
Genetic and Functional Evidence Supports LPAR1 as a Susceptibility Gene for Hypertension.
Tian et al., Beijing, China. In Hypertension, Sep 2015
In this study, we assessed the genetic association of lysophosphatidic acid receptors with essential hypertension by genotyping 28 single-nucleotide polymorphisms from genes encoding for lysophosphatidic acid receptors, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, and LPAR6 and their flanking sequences, in 3 Han Chinese cohorts consisting of 2630 patients and 3171 controls in total.
Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.
Yun et al., Atlanta, United States. In Am J Physiol Cell Physiol, Aug 2015
We have shown previously that lysophosphatidic acid (LPA), a small phospholipid produced ubiquitously by all types of cells, stimulates NHE3 via LPA5 receptor.
Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells.
Tsujiuchi et al., Ōsaka, Japan. In Biochem Biophys Res Commun, Jun 2015
In the present study, to assess the roles of LPA4, LPA5 and LPA6 in cellular functions of pancreatic cancer cells, we generated LPA receptor knockdown cells from PANC-1 cells (PANC-sh4, PANC-sh5 and PANC-sh6 cells, respectively).
Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma.
Murray et al., Kuala Lumpur, Malaysia. In J Pathol, Feb 2015
Focusing on the first of these phenotypes, we show that one of the LPA receptors, LPA receptor 5 (LPAR5), is down-regulated in primary NPC tissues and that this down-regulation promotes the LPA-induced migration of NPC cell lines.
Analysis of the protein related receptor GPR92 in G-cells.
Haid et al., Stuttgart, Germany. In Front Physiol, 2014
Our previous studies have shown that G-cells express suitable receptor types, most notably the peptone-receptor GPR92 and the amino acid receptors GPRC6A and CaSR; however, their relative importance remained unclear.
Uncovering unique roles of LPA receptors in the tumor microenvironment.
Tigyi et al., Memphis, United States. In Receptors Clin Investig, 2014
First, our in vitro findings demonstrate that LPA receptors, specifically LPA2 and LPA5 expressed in B16F10 cells appear to have opposing roles in cell invasion; the former seems to be responsible for the high basal invasion rate of B16F10 cells while the latter is anti-invasive upon exogenous LPA stimulation.
Cross-species comparison of genes related to nutrient sensing mechanisms expressed along the intestine.
Meijerink et al., Wageningen, Netherlands. In Plos One, 2013
The gene expression of glucagon, cholecystokinin, peptide YY, glucagon-like peptide-1 receptor, taste receptor T1R3, sodium/glucose cotransporter, peptide transporter-1, GPR120, taste receptor T1R1, GPR119 and GPR93 was investigated.
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.
Harmar et al., Cambridge, United Kingdom. In Pharmacol Rev, 2013
The following recommendations are made for new receptor names based on 11 pairings for class A GPCRs: hydroxycarboxylic acid receptors [HCA₁ (GPR81) with lactate, HCA₂ (GPR109A) with 3-hydroxybutyric acid, HCA₃ (GPR109B) with 3-hydroxyoctanoic acid]; lysophosphatidic acid receptors [LPA₄ (GPR23), LPA₅ (GPR92), LPA₆ (P2Y5)]; free fatty acid receptors [FFA4 (GPR120) with omega-3 fatty acids]; chemerin receptor (CMKLR1; ChemR23) with chemerin; CXCR7 (CMKOR1) with chemokines CXCL12 (SDF-1) and CXCL11 (ITAC); succinate receptor (SUCNR1) with succinate; and oxoglutarate receptor [OXGR1 with 2-oxoglutarate].
Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain.
Chun et al., Los Angeles, United States. In J Biol Chem, 2012
These data expand the influences of LPA signaling in neuropathic pain through a second LPA receptor subtype, LPA(5), involving a mechanistically distinct downstream signaling pathway compared with LPA(1).
Recent advances in gut nutrient chemosensing.
Kaunitz et al., Los Angeles, United States. In Curr Med Chem, 2011
Family A GPCRs includes receptor GPR93, which senses protein and proteolytic degradation products, and free fatty acid-sensing receptors.
Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells.
Yun et al., Atlanta, United States. In Am J Physiol Cell Physiol, 2011
It was shown that lysophosphatidic acid 5 receptor transactivated the epidermal growth factor receptor and that inhibition of epidermal growth factor receptor blocked lysophosphatidic acid 5 receptor-dependent activation of NHE3.
Non-Edg family LPA receptors: the cutting edge of LPA research.
Ishii et al., Tokyo, Japan. In J Biochem, 2011
The discovery of this receptor, which is structurally distinct from the Edg family LPA receptors, led to the identification of two additional LPA receptors, LPA5 and LPA6, homologous to LPA4.
LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β release.
Boyce et al., Boston, United States. In Plos One, 2010
LPA5 is a bona fide LPA receptor on human mast cells responsible for the majority of LPA induced MIP-1beta release.
LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid.
Aoki et al., Sendai, Japan. In Prog Lipid Res, 2010
So far, six GPCRs for LPA have been identified: LPA(1)/Edg2, LPA(2)/Edg4, LPA(3)/Edg7, LPA(4)/GPR23/P2Y9, LPA(5)/GPR92 and LPA(6)/P2Y5.
LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4.
Billiard et al., United States. In J Cell Biochem, 2010
LPA4 and LPA5 receptors induce osteoblastic differentiation of human mesenchymal stem cells
Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression.
Gibson et al., Winnipeg, Canada. In Leuk Lymphoma, 2009
Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients.
LPA receptors: subtypes and biological actions.
Chun et al., Los Angeles, United States. In Annu Rev Pharmacol Toxicol, 2009
They are encoded by distinct genes named LPAR1-LPAR5 in humans and Lpar1-Lpar5 in mice.
The emerging role of promiscuous 7TM receptors as chemosensors for food intake.
Bräuner-Osborne et al., Copenhagen, Denmark. In Vitam Horm, 2009
In the present review, we describe the molecular mechanisms of nutrient-sensing of the calcium-sensing receptor (CaR), the G protein-coupled receptor family C, group 6, subtype A (GPRC6A), and the taste1 receptor T1R1/T1R3-sensing L-α-amino acids; the carbohydrate-sensing T1R2/T1R3 receptor; the proteolytic degradation product sensor GPR93 (also termed GPR92); and the FFA sensing receptors FFA1, FFA2, FFA3, GPR84, and GPR120.
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.
Betz et al., Bonn, Germany. In Nat Genet, 2008
Homology and studies of signaling transduction pathways suggest that P2Y5 is a member of a subgroup of LPA receptors, which also includes LPA4 and LPA5.
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