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G protein-coupled receptor 87

GPR87, G protein-coupled receptor 87, GPR95
This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: ACID, P2Y, CAN, V1a, p53
Papers on GPR87
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells.
Kakehi et al., Japan. In Int J Mol Sci, 2014
G protein-coupled receptor 87 (GPR87) is a newly deorphanized member of the cell surface molecule G protein-coupled receptor family.
Overexpression of G protein-coupled receptor 87 correlates with poorer tumor differentiation and higher tumor proliferation in non-small-cell lung cancer.
Yokomise et al., Japan. In Mol Clin Oncol, 2014
G protein-coupled receptor 87 (GPR87) is a newly deorphanized member of the transmembrane G protein-coupled receptor family.
GPR87 mediates lysophosphatidic acid-induced colony dispersal in A431 cells.
Fujita et al., Kusatsu, Japan. In Eur J Pharmacol, 2013
We have previously reported that an orphan G protein-coupled receptor GPR87 was activated by lysophosphatidic acid (LPA) and that it induced an increase in the intracellular Ca(2+) levels in the CHO cells genetically engineered to express GPR87-Gα16 fusion protein.
Computational analysis of the 3-D structure of human GPR87 protein: implications for structure-based drug design.
Khattri et al., Lucknow, India. In Asian Pac J Cancer Prev, 2012
The G-protein coupled receptor 87 (GPR87) is a recently discovered orphan GPCR which means that the search of their endogenous ligands has been a novel challenge.
Expression and role of GPR87 in urothelial carcinoma of the bladder.
Kakehi et al., Japan. In Int J Mol Sci, 2012
The orphan GPR87 has recently been matched with its ligand LPA, which is a lipid mediator with multiple physiological functions, including cancer cell proliferation.
G protein-coupled receptor 87 (GPR87) promotes the growth and metastasis of CD133⁺ cancer stem-like cells in hepatocellular carcinoma.
Li et al., Shanghai, China. In Plos One, 2012
Gene expression analysis of the CD133(+) and CD133(-) cells of the HCC line SMMC-7721 revealed that G protein-coupled receptor 87 (GPR87) is highly expressed in CD133(+) HCC cells.
Systematic identification and characterization of novel human skin-associated genes encoding membrane and secreted proteins.
Zlotnik et al., Düsseldorf, Germany. In Plos One, 2012
Four of these are expressed specifically by epidermal keratinocytes; two that encode G-protein-coupled receptors (GPR87 and GPR115), and two that encode secreted proteins (WFDC5 and SERPINB7).
G Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery.
Chen et al., Davis, United States. In Mol Cell Pharmacol, 2010
GPR87, a cell surface GPR related to the LPA receptor family, is overexpressed in diverse carcinomas and plays an essential role in tumor cell survival.
Utilization of the Tango beta-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation.
Hanson et al., Madison, United States. In J Biomol Screen, 2009
The authors describe the use of this technique to build cell-based receptor-specific assays for all 8 members of the EDG receptor family as well as the related LPA receptors GPR23, GPR92, and GPR87.
The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress.
Chen et al., Davis, United States. In Cancer Res, 2009
GPR87 knockdown sensitized cancer cells to DNA damage-induced growth suppression via enhanced p53 stabilization and activation.
Serum proteomic approach for the identification of serum biomarkers contributed by oral squamous cell carcinoma and host tissue microenvironment.
Alaoui-Jamali et al., Montréal, Canada. In J Proteome Res, 2009
Differentially expressed proteins of human origin included the epidermal growth factor receptor (EGFR), cytokeratins, G-protein coupled receptor 87, Rab11 GTPase, PDZ-domain containing proteins, and PEST-containing nuclear proteins.
Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer.
Peyruchaud, Lyon, France. In Anticancer Agents Med Chem, 2009
During the past decade, studies revealed that LPA and S1P interact with a large series of G-protein-coupled receptors, at least seven for LPA (LPA1-5, GPR-87, P2Y5) and five for S1P (S1P1-5).
Two pathways for lysophosphatidic acid production.
Okudaira et al., Sendai, Japan. In Biochim Biophys Acta, 2008
So far, five GPCRs, designated LPA1-5, and, more recently, two additional GPCRs, GPR87 and P2Y5, have been identified as receptors for LPA.
hGPR87 contributes to viability of human tumor cells.
Sommergruber et al., Vienna, Austria. In Int J Cancer, 2008
Human GPR87 mRNA transcript was preferentially overexpressed in squamous cell carcinomas. Up-regulation of both, transcript and protein, was detected in samples of SCC of the lung, cervix, skin and head and neck (pharynx, larynx and epiglottis).
GPR87 is an overexpressed G-protein coupled receptor in squamous cell carcinoma of the lung.
Reubi et al., Bern, Switzerland. In Dis Markers, 2007
G-protein coupled receptor(GPR87) stands out as a candidate for further target validation due to its marked overexpression and correlation on a mutation-based level to squamous cell carcinoma
LPA and its analogs-attractive tools for elucidation of LPA biology and drug development.
Aoki et al., Sendai, Japan. In Curr Med Chem, 2007
So far, seven GPCRs (LPA(1-5) and recently reported GPR87/LPA(6) and P2Y5/LPA(7)) and a nuclear hormone receptor, PPARgamma, have been identified.
The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
Fujita et al., Kusatsu, Japan. In Biochem Biophys Res Commun, 2007
Results suggest that the GPR87 is a LPA receptor which evolved from a common ancestor of P2Y receptors.
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