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G protein-coupled receptor 56

GPR56, serpentine receptor, TM7XN1
This gene encodes a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis. Mutations in this gene result in bilateral frontoparietal polymicrogyria. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: CAN, GPCR, V1a, Frizzled, ACID
Papers on GPR56
Magnetic Resonance Imaging of Malformations of Midbrain-Hindbrain.
Castillo et al., Al Manşūrah, Egypt. In J Comput Assist Tomogr, Jan 2016
Cerebellar dysplasias are seen in Chudley-McCullough syndrome, associated with LAMA1 mutations and GPR56 mutations; Lhermitte-Duclos disease; and focal cerebellar dysplasias.
Stalk-dependent and stalk-independent signaling by the adhesion G protein-coupled receptors GPR56 (ADGRG1) and BAI1 (ADGRB1).
Hall et al., United States. In J Biol Chem, Jan 2016
Several aGPCRs, including ADGRB1 (BAI1 or B1) and ADGRG1 (GPR56 or G1), have been found to exhibit significantly increased constitutive activity when truncated to mimic GAIN domain cleavage ("ΔNT").
Differential gene expression patterns between smokers and non-smokers: cause or consequence?
Boomsma et al., Amsterdam, Netherlands. In Addict Biol, Dec 2015
Cis-expression quantitative trait loci for GPR56 and RARRES3 (downregulated in smokers) were associated with increased number of cigarettes smoked per day in a large genome-wide association meta-analysis, suggesting a causative effect of GPR56 and RARRES3 expression on smoking behavior.
GPR56-Related Polymicrogyria: Clinicoradiologic Profile of 4 Patients.
Udani et al., Mumbai, India. In J Child Neurol, Nov 2015
GPR56 is the only confirmed gene associated with bilateral frontoparietal polymicrogyria.
Novel endogenous angiogenesis inhibitors and their therapeutic potential.
Ge et al., Singapore, Singapore. In Acta Pharmacol Sin, Oct 2015
In this review, we highlight ten novel endogenous protein angiogenesis inhibitors discovered within the last five years, including ISM1, FKBPL, CHIP, ARHGAP18, MMRN2, SOCS3, TAp73, ZNF24, GPR56 and JWA.
The RNA-binding protein PCBP2 inhibits Ang II-induced hypertrophy of cardiomyocytes though promoting GPR56 mRNA degeneration.
Mei et al., Shanghai, China. In Biochem Biophys Res Commun, Sep 2015
Here we reported that PCBP2 is an anti-hypertrophic factor by inhibiting GPR56 mRNA stability.
Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist.
Tall et al., Rochester, United States. In Proc Natl Acad Sci U S A, Jun 2015
We examined aGPCR activation using two prototypical aGPCRs, GPR56 and GPR110.
[Maintenance of leukemic and normal hematopoietic stem cells in bone marrow niches by EVI1-regulated GPR56].
Morishita et al., Miyazaki, Japan. In Rinsho Ketsueki, Apr 2015
We identified G protein-coupled receptor 56 (GPR56) as a novel marker for EVI1high AML, which is an orphan adhesion G protein-coupled receptor (GPCR).
Epilepsy and malformations of cortical development: new developments.
Kuzniecky, New York City, United States. In Curr Opin Neurol, Apr 2015
Regulatory G protein GPR56 mutations can selectively cause polymicrogyria in the Sylvian fissure bilaterally.
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Schiöth et al., Amsterdam, Netherlands. In Pharmacol Rev, 2014
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98).
Identification of candidate gonadal sex differentiation genes in the chicken embryo using RNA-seq.
Smith et al., Australia. In Bmc Genomics, 2014
We further characterised three female-biased (ovarian) genes; calpain-5 (CAPN5), G-protein coupled receptor 56 (GPR56), and FGFR3 (fibroblast growth factor receptor 3).
Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.
Walsh et al., Boston, United States. In Science, 2014
Here, we describe a 15-base pair deletion mutation in a regulatory element of GPR56 that selectively disrupts human cortex surrounding the Sylvian fissure bilaterally including "Broca's area," the primary language area, by disrupting regional GPR56 expression and blocking RFX transcription factor binding.
Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex.
Piao et al., Boston, United States. In J Comp Neurol, 2012
We revealed that GPR56 is expressed in multiple cell types in the preplate, marginal zone, subventricular zone, and ventricular zone in the developing cerebral cortex
Disease-associated mutations prevent GPR56-collagen III interaction.
Piao et al., Boston, United States. In Plos One, 2011
Disease-associated mutations prevent GPR56-collagen III interaction.
Specific expression of GPR56 by human cytotoxic lymphocytes.
Hamann et al., Taiwan. In J Leukoc Biol, 2011
GPR56 expression is a common trait of human cytotoxic lymphocytes and might affect the migratory properties of these cells.
Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes.
Bargmann et al., New York City, United States. In Nature, 2011
In each strain, resistance to the pheromone ascaroside C3 results from a deletion that disrupts the adjacent chemoreceptor genes serpentine receptor class g (srg)-36 and -37.
GPR56 Regulates VEGF production and angiogenesis during melanoma progression.
Xu et al., Rochester, United States. In Cancer Res, 2011
consistent with its suppressive roles in melanoma progression, the expression levels of GPR56 are inversely correlated with the malignancy of melanomas in human subjects
G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination.
Piao et al., Boston, United States. In Proc Natl Acad Sci U S A, 2011
Data show that that Col3a1 null mutant mice exhibit overmigration of neurons beyond the pial basement membrane and a cobblestone-like cortical malformation similar to the phenotype seen in Gpr56 null mutant mice.
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
de Sauvage et al., San Francisco, United States. In Science, 2009
GDC-0449, a drug that inhibits Hh signaling by targeting the serpentine receptor Smoothened (SMO), has produced promising anti-tumor responses in early clinical studies of cancers driven by mutations in this pathway.
G protein-coupled receptor-dependent development of human frontal cortex.
Walsh et al., Boston, United States. In Science, 2004
preferential expression in neuronal progenitor cells of the cerebral cortical ventricular and subventricular zones duing periods of neurogenesis
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