G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.
Coleraine, United Kingdom. In Acta Diabetol, Feb 2016
In addition, GPR43 also couples to the Gαq subunit augmenting intracellular Ca(2+) and activating phospholipase C. GPR55 is specific for cannabinoid endogenous agonists (endocannabinoids) and non-cannabinoid fatty acids, which couples to Gα12/13 and Gαq proteins, leading to enhancing intracellular Ca(2+), extracellular signal-regulated kinase 1/2 (ERK) phosphorylation and Rho kinase.
Lysophosphatidylinositol Signalling and Metabolic Diseases.
Kuantan, Malaysia. In Metabolites, Dec 2015
In this review, we will focus on the physiological and pathophysiological roles of the lysophospholipid mediator lysophosphatidylinositol (LPI) and its receptor G-protein coupled receptor 55 (GPR55) in metabolic diseases.