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G protein-coupled receptor 22

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, GPR21, GPR20, RIIbeta, HAD
Papers on GPR22
Expression of orphan receptors GPR22 and GPR162 in streptozotocin-induced diabetic rats.
Villafaña et al., Mexico. In J Recept Signal Transduct Res, Feb 2015
Therefore, the aim of this work was to study the expression of the orphan receptors GPR22 and GPR162 in heart, aorta, brain and kidney of diabetic rats.
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
Orphan G-protein coupled receptor 22 (Gpr22) regulates cilia length and structure in the zebrafish Kupffer's vesicle.
Tylzanowski et al., Leuven, Belgium. In Plos One, 2013
GPR22 is an orphan G protein-coupled receptor (GPCR).
Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22.
Loughlin et al., Newcastle upon Tyne, United Kingdom. In Ann Rheum Dis, 2012
OBJECTIVES: An osteoarthritis (OA) susceptibility locus has been mapped to chromosome 7q22, to a region of high-linkage disequilibrium encompassing six genes: PRKAR2B, HBP1, COG5, GPR22, DUS4L and BCAP29.
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.
Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA) et al., Ioánnina, Greece. In Ann Rheum Dis, 2011
CONCLUSION: The associated signal is located within a large (500 kb) linkage disequilibrium block that contains six genes: PRKAR2B (protein kinase, cAMP-dependent, regulatory, type II, β), HPB1 (HMG-box transcription factor 1), COG5 (component of oligomeric golgi complex 5), GPR22 (G protein-coupled receptor 22), DUS4L (dihydrouridine synthase 4-like) and BCAP29 (B cell receptor-associated protein 29).
The genetic epidemiology of osteoarthritis.
Spector et al., London, United Kingdom. In Curr Opin Rheumatol, 2010
GWAS have reported structural genes (COL6A4), inflammation-related genes (PTGS2/PLA2G4A) and a locus on chr 7q22 (GPR22 and four other genes in the same linkage disequilibrium block) associated with osteoarthritis.
A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.
van Meurs et al., Rotterdam, Netherlands. In Arthritis Rheum, 2010
This SNP is in almost complete linkage disequilibrium with rs3757713 (68 kb upstream of GPR22), which is associated with GPR22 expression levels in lymphoblast cell lines (P = 4 x 10(-12)).
Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor.
Connolly et al., San Diego, United States. In Am J Physiol Heart Circ Physiol, 2008
Demonstrate GRR22 expression in mouse heart. Identified a protective role for GPR22 in response to hemodynamic stress resulting from increased afterload.
Effects of RNA degradation on gene expression analysis of human postmortem tissues.
Hevezi et al., San Diego, United States. In Faseb J, 2005
As examples of potential uses, we report novel expression sites for four potential therapeutic targets--CCL27, GPR22, GPR113 and GPR128--and as well as a set of thymus-specific genes, including three not previously associated with the thymus.
Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.
George et al., Toronto, Canada. In Gene, 1997
This resulted in the isolation of genes GPR21, GPR22 and GPR23.
Degenerate primers based on highly conserved regions of amino acid sequence in papillomaviruses can be used in a generalized polymerase chain reaction to detect productive human papillomavirus infection.
Walboomers et al., Amsterdam, Netherlands. In J Gen Virol, 1991
Conserved amino acid sequences within the L1 open reading frame of the human papillomavirus (HPV) genome were used as a basis to design two degenerate primers (GP17 and GP18) and one general probe (GPR22) which direct polymerase chain reaction (PCR) amplification and subsequent detection of a 620 to 660 bp DNA fragment.
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