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G protein-coupled receptor 125

GPR125, TEM5-like, G protein-coupled receptor 125
Top mentioned proteins: CAN, PLZF, Thy-1, PGP 9.5, GFRalpha1
Papers on GPR125
Expansion and long-term culture of human spermatogonial stem cells via the activation of SMAD3 and AKT pathways.
He et al., Shanghai, China. In Exp Biol Med (maywood), Aug 2015
We isolated GPR125-positive spermatogonia with high purity and viability from adult human testicular tissues utilizing the two-step enzymatic digestion and magnetic-activated cell sorting with antibody against GPR125.
The molecular signature and spermatogenesis potential of newborn chicken spermatogonial stem cells in vitro.
Dastpak et al., Mashhad, Iran. In In Vitro Cell Dev Biol Anim, Apr 2015
In this regard, we found that colony-forming cells (SSCs) in newborn chicken testicular cell cultures were positive for alkaline phosphatase activity and also expressed specific markers including DAZL, STRA-8, CVH, PLZF, SPRY-1, GFRα1, GDNF, POU5F1, NANOG, GPR125, THY-1, c-KIT, and BCL6B, at mRNA level.
[Isolation, culture, and identification of human spermatogonial stem cells].
Li et al., In Zhonghua Nan Ke Xue, Mar 2015
RESULTS: The isolated CD90-positive cells showed a relatively homogeneous characteristic in size and morphology and expressed the genes specific for human SSCs, with high expressions (90.5%) of GFRA1, GPR125, and UCHL1.
Genome-wide association study for female fertility in Nordic Red cattle.
Sahana et al., Århus, Denmark. In Bmc Genet, 2014
Furthermore the genes assigned to the most significant SNP for FTI were located on BTA6 (GPR125), BTA13 (ANKRD60), BTA15 (GRAMD1B), and BTA24 (ZNF521).
Establishment and Characterization of Human Germline Stem Cell Line with Unlimited Proliferation Potentials and no Tumor Formation.
He et al., Shanghai, China. In Sci Rep, 2014
RT-PCR, immunocytochemistry, and Western blots revealed that this cell line was positive for a number of human spermatogonial and SSC hallmarks, including VASA, DAZL, MAGEA4, GFRA1, RET, UCHL1, GPR125, PLZF and THY1, suggesting that these cells are human SSCs phenotypically.
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Schiöth et al., Amsterdam, Netherlands. In Pharmacol Rev, 2014
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98).
Quantitative detection of human spermatogonia for optimization of spermatogonial stem cell culture.
Dann et al., Bloomington, United States. In Hum Reprod, 2014
Primary testicular cell cultures were further characterized by comparing to testicular somatic cell cultures using quantitative reverse transcriptase PCR (UTF1, FGFR3, ZBTB16, GPR125, DAZL, GATA4 and VIM) and flow cytometry (CD9 and SSEA4).
Enrichment of spermatogonial stem cells from long-term cultured human testicular cells.
van Pelt et al., Amsterdam, Netherlands. In Fertil Steril, 2014
MAIN OUTCOME MEASURE(S): Enrichment for human spermatogonia and SSCs tested by expression analysis of spermatogonial markers ITGA6, GPR125, ZBTB16, UCHL1, and ID4 using quantitative real-time polymerase chain reaction (qPCR) and by xenotransplantation into the testes of mice, respectively.
Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors.
Seandel et al., New York City, United States. In Andrology, 2014
Among the genes recently linked to SSCs in mice and other animals are the basic helix-loop-helix transcription factor ID4 and the orphan G-protein-coupled receptor GPR125.
Eliminating acute lymphoblastic leukemia cells from human testicular cell cultures: a pilot study.
Repping et al., Amsterdam, Netherlands. In Fertil Steril, 2014
The presence of spermatogonia at the end of culture was determined by reverse transcription-polymerase chain reaction for ZBTB16, UCHL1, and GPR125.
Reconstruction of mouse testicular cellular microenvironments in long-term seminiferous tubule culture.
Ventelä et al., Turku, Finland. In Plos One, 2013
The co-culture is composed of the constituents of testicular stem cell niche: Sertoli cells [identified by expression of Wilm's tumour antigen 1 (WT1) and secretion of glial cell line-derived neurotrophic factor, GDNF], peritubular myoid cells (expressing alpha smooth muscle actin, αSMA) and spermatogonia [expressing MAGE-B4, PLZF (promyelocytic leukaemia zinc finger), LIN28, Gpr125 (G protein-coupled receptor 125), CD9, c-Kit and Nanog], and can be maintained for at least five weeks.
Long-term Culture of Human SSEA-4 Positive Spermatogonial Stem Cells (SSCs).
Golestaneh et al., Georgetown, Guyana. In J Stem Cell Res Ther, 2011
Here using SSEA-4 as an optimal marker for isolation of a subpopulation of SSCs, we show that SSEA-4 positive cells express the highest level of SSC genes compared to other subpopulations isolated with different markers, and can be maintained in culture for over 14 passages which we were unable to obtain with other SSCs markers including GPR125 and ITGA6.
Human spermatogonial stem cells: a possible origin for spermatocytic seminoma.
Hofmann et al., Urbana, United States. In Int J Androl, 2011
One such marker, the orphan receptor GPR125, is a plasma membrane protein that can be used to isolate human SSCs.
Spermatogonial stem cells: unlimited potential.
Kokkinaki et al., Washington, D.C., United States. In Reprod Fertil Dev, 2008
We now demonstrate that G protein-coupled receptor 125 (GPR125) may be a marker for human SSCs.
The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury.
Schiöth et al., Uppsala, Sweden. In Bmc Neurosci, 2007
Data show that GPR125 is specifically expressed in cells of the choroid plexus and is upregulated following traumatic brain injury.
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Rafii et al., New York City, United States. In Nature, 2007
GPR125+ multipotent adult stem cells generated derivatives of the three germ layers and contributed to chimaeric embryos, with concomitant downregulation of GPR125 during differentiation into GPR125- cells
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