Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics.
Jinan, China. In Future Med Chem, Dec 2015
BACKGROUND: Free fatty acid 4 (FFA4) (GPR120) receptor functions as a receptor for unsaturated long-chain free fatty acids by regulating the secretion of glucagon-like peptide-1 and suppressing the inflammatory process, in which these two distinct biological functions are modulated by two signaling pathways, Gq and β-arrestin2, respectively.
GPR 120; the potential target for obesity treatment.
Cairo, Egypt. In Endocr Metab Immune Disord Drug Targets, Dec 2015
UNASSIGNED: G protein coupled receptor 120 (GPR120) is a class of receptors in the gastrointestinal tract (GIT) that is implicated in nutrient sensing and body weight regulation.
FFA4/GPR120 agonists: a survey of the recent patent literature.
Napoli, Italy. In Pharm Pat Anal, Nov 2015
FFA4/GPR120, a member of the rhodopsin family of G-protein-coupled receptors (GPCRs), is becoming an important target for therapeutic intervention in several areas of disease, including metabolic diseases, inflammation and cancer.
München, Germany. In Cell, 2014
In this issue, Yore et al. report a group of branched fatty acid esters of hydroxy fatty acids that regulate insulin secretion and glucose uptake through the activation of GPR120.