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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Integrin, alpha 2b

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD45, Gp, HAD, CAN, P-selectin
Papers using GPIIb antibodies
Resolvin D1 binds human phagocytes with evidence for proresolving receptors.
Hartl Dominik, In PLoS ONE, 2009
... Phycoerythrin (PE)-conjugated mouse anti-human CD62P was obtained from Pharmingen (San Jose, CA) and mouse anti-human FITC-CD41 from BD Biosciences (Rockville, MD) ...
Antiplatelet antibodies in WASP(−) mice correlate with evidence of increased in vivo platelet consumption.
Schulz Christian, In PLoS ONE, 2008
... Mouse anti-Human CD41 (clone HIP8), PE labeled mouse anti-human CD61, and PE labeled Mouse anti-human CD41 were obtained from BD Biosciences.
Model-based analysis of ChIP-Seq (MACS)
Göttgens Berthold et al., In Developmental Biology, 2007
... following mAbs were used for cell sorting: APC–anti-Flk1 (AVAS12), biotin–anti-VE-cadherin (VECD1; followed by streptavidin–PE–Cy7), and PE–anti–CD41 (MWreg30; eBioscience).
Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain.
Kleinschnitz Christoph, In PLoS ONE, 2002
... Rat anti-mouse CD41 monoclonal antibody (mAb) and fluorescein isothiocyanate (FITC) labeled anti-CD61 mAb were from BD Biosciences (San Diego, CA) ...
Platelet-like particle formation in the human megakaryoblastic leukaemia cell lines, MEG-01 and MEG-01s.
Laneuville Odette et al., In Biological Procedures Online, 1997
... Monoclonal mouse anti-human platelet CD41 (5B12) was obtained from DAKO (Carpintera, CA) ...
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Papers on GPIIb
Effect of Remote Ischemic Preconditioning on Platelet Activation Induced by Coronary Procedures.
Crea et al., Roma, Italy. In Am J Cardiol, Mar 2016
Monocyte-platelet aggregate (MPA) formation and platelet CD41 in the MPA gate and CD41 and CD62 expression in the platelet gate were assessed by flow cytometry, in the absence and in the presence of adenosine diphosphate (ADP) stimulation.
Platelet activation at the onset of human endotoxemia is undetectable in vivo.
Assinger et al., Vienna, Austria. In Platelets, Feb 2016
Blood was drawn before, 10, 30 and 60 min after LPS challenge and platelet activation analyzed by flow cytometry (GPIIb/IIIa activation, surface CD62P and CD40L, intraplatelet reactive oxygen formation and platelet-leukocyte aggregates) and ELISA (sCD40L, sCD62P and CXCL4).
Aged Garlic Extract Inhibits Human Platelet Aggregation by Altering Intracellular Signaling and Platelet Shape Change.
Smith et al., Liverpool, United Kingdom. In J Nutr, Feb 2016
This leads to the activation of the glycoprotein IIb/IIIa (GPIIb/IIIa) fibrinogen receptor, resulting in platelet shape change.
Initial evidence that blood-borne microvesicles are biomarkers for recurrence and survival in newly diagnosed glioblastoma patients.
Koch et al., Philadelphia, United States. In J Neurooncol, Feb 2016
Microvesicles were isolated using serial centrifugation and stained for surface markers (Annexin V for phosphotidyl serine, CD41 for platelets, anti-EGFR for tumor cells, and CD235 for red blood cells).
Platelet-targeting thiol reduction sensor detects thiol isomerase activity on activated platelets in mouse and human blood under flow.
Diamond et al., Philadelphia, United States. In J Thromb Haemost, Feb 2016
With anti-mouse CD41 PDI-sAb used in an arteriolar laser injury model, thiol reductase activity localized in the core of growing thrombi where platelets displayed P-selectin and were in close proximity to disrupted endothelium.
Dynamics of circulating microparticles in chronic kidney disease and transplantation: Is it really reliable marker?
Unsur et al., Kayseri, Turkey. In World J Transplant, Jan 2016
EMPs having CD144, CD 146, CD31(+)/CD41(-), CD51 and CD105 may be used to evaluate the vascular endothelial cell damage and determine asymptomatic patients who might be at higher risk of developing cardiovascular disease in CKD and renal transplant.
Effects Of Glycoprotein IIb/IIIa Antagonists: Anti Platelet Aggregation And Beyond.
Romano et al., Napoli, Italy. In Curr Drug Metab, Jan 2016
UNASSIGNED: The use of inhibitors of glycoprotein IIb/IIIa (GPIIb/IIIa) has provided dramatic results in terms of the prevention of acute stent thrombosis and a reduction in major adverse coronary events in patients subjected to percutaneous coronary intervention.
Bivalirudin Anticoagulant Therapy With or Without Platelet Glycoprotein IIb/IIIa Inhibitors During Transcatheter Coronary Interventional Procedures: A Meta-Analysis.
Jin et al., Chongqing, China. In Medicine (baltimore), Aug 2015
Meta-regression analyses demonstrated that additional administration of GP IIb/IIIa receptor inhibitors (P = 0.01), especially eptifibatide (P = 0.001) and tirofiban (P = 0.002), was likely to increase the major bleeding risk associated with bivalirudin.Bivalirudin, in comparison to heparin, is associated with a markedly lower risk of major bleeding, and the additional use of GP IIb/IIIa inhibitors may weaken this benefit.
Glycoprotein IIb/IIIa inhibitors: The resurgence of tirofiban.
Harmon et al., Lexington, United States. In Vascul Pharmacol, Aug 2015
Tirofiban, eptifibatide, and abciximab are the three GP IIb/IIIa inhibitors approved for use in the United States.
Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options.
Solh et al., United States. In J Blood Med, 2014
Glanzmann's thrombasthenia (GT) is a genetic platelet surface receptor disorder of GPIIb/IIIa (ITG αIIbβ3), either qualitative or quantitative, which results in faulty platelet aggregation and diminished clot retraction.
Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial.
HEAT-PPCI trial investigators et al., Liverpool, United Kingdom. In Lancet, 2014
The rate of GP IIb/IIIa inhibitor use was much the same between groups (122 patients [13%] in the bivalirudin group and 140 patients [15%] in the heparin group).
Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance.
Kubes et al., Calgary, Canada. In Nat Immunol, 2013
Bacteria such as Bacillus cereus and methicillin-resistant Staphylococcus aureus (MRSA) were rapidly caught by KCs and triggered platelets to switch from 'touch-and-go' adhesion to sustained GPIIb-mediated adhesion on the KC surface to encase the bacterium.
Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia.
Tomiyama et al., Ōsaka, Japan. In Blood, 2012
These results suggested that platelet associated anti-alphaIIbbeta3 antibodies in primary primary immune thrombocytopenia tended to recognize highly restricted regions of alphaIIb with clonality.
Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanism.
Zhu et al., Los Angeles, United States. In J Biol Chem, 2012
We propose a new inside-out activation mechanism for integrin alpha(IIb)beta(3) and by inference, all of the integrins in their native cellular environment.
Novel single-chain antibody-targeted microbubbles for molecular ultrasound imaging of thrombosis: validation of a unique noninvasive method for rapid and sensitive detection of thrombi and monitoring of success or failure of thrombolysis in mice.
Ahrens et al., Australia. In Circulation, 2012
Glycoprotein IIb/IIIa-targeted microbubbles specifically bind to activated platelets in vitro, allowing real-time molecular imaging of acute arterial thrombosis in a mouse model.
Clinical disability progression and platelet GP IIb/IIIa values in patients with atopic myelitis.
Kira et al., Fukuoka, Japan. In J Neuroimmunol, 2012
Disease duration of atopic myelitis is reflected in significantly higher GP IIb/IIIa values than in controls and involves the sensory system, with increased platelet aggregative function.
Homozygous point mutations in platelet glycoprotein ITGA2B gene as cause of Glanzmann thrombasthenia in 2 families.
Zieger et al., Freiburg, Germany. In Klin Padiatr, 2012
Family 1 was identified with c.1878G>C and family 2 with c.1787T>C substitution. While the c.1787T>C mutation causes a single amino acid substitution p.I565T, the c.1878G>C mutation (p.Q595H) is predicted to induce a mRNA splicing anomaly.
HoxA3 is an apical regulator of haemogenic endothelium.
Kyba et al., Minneapolis, United States. In Nat Cell Biol, 2011
We show here that HoxA3, a gene uniquely expressed in the embryonic but not yolk sac vasculature, restrains haematopoietic differentiation of the earliest endothelial progenitors, and induces reversion of the earliest haematopoietic progenitors into CD41-negative endothelial cells.
Low-dose vs standard-dose unfractionated heparin for percutaneous coronary intervention in acute coronary syndromes treated with fondaparinux: the FUTURA/OASIS-8 randomized trial.
Yusuf et al., In Jama, 2010
INTERVENTIONS: Patients received intravenously either low-dose unfractionated heparin, 50 U/kg, regardless of use of glycoprotein IIb/IIIa (GpIIb-IIIa) inhibitors or standard-dose unfractionated heparin, 85 U/kg (60 U/kg with GpIIb-IIIa inhibitors), adjusted by blinded activated clotting time (ACT).
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium.
Robin et al., Rotterdam, Netherlands. In Nature, 2010
Here we show the dynamic de novo emergence of phenotypically defined HSCs (Sca1(+), c-kit(+), CD41(+)) directly from ventral aortic haemogenic endothelial cells.
More papers using GPIIb antibodies
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3
Shattil Sanford J. et al., In The Journal of Cell Biology, 1997
... R-phycoerythrin–conjugated rat anti–mouse CD41 antibody (MWReg30) was purchased from BD Biosciences.
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