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Glycosylphosphatidylinositol specific phospholipase D1

GPI-PLD, glycosylphosphatidylinositol-specific phospholipase D, GPI-specific phospholipase D
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, Insulin, PLC, HAD
Papers on GPI-PLD
Inhibition of CEA release from epithelial cells by lipid A of Gram-negative bacteria.
Hosseinzadeh et al., In Cell Mol Biol Lett, Sep 2015
Previous studies showed that CEA is released from epithelial cells by an endogenous GPI-PLD enzyme.
Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease.
Kim et al., Anyang, South Korea. In Plos One, 2014
Recently, GPI-phospholipase D (GPI-PLD) was shown to be a strictly specific enzyme for GPI anchors.
[GPI-PLD inhibits the growth of hepatoma cells by down-regulation of PI3K-Akt signaling pathway].
Tang et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2014
OBJECTIVE: To clarify the effect of glycosylphosphatidylinositol-specific phospholipase D (GPIPLD) on hepatoma cells HepG2 and the possible molecular mechanism.
Insulin-mimicking bioactivities of acylated inositol glycans in several mouse models of diabetes with or without obesity.
d'Alarcao et al., Sendai, Japan. In Plos One, 2013
Acylated inositol glycans (AIGs) are generated by cleavage of protein-free GPI precursors through the action of GPI-specific phospholipase C (GPI-PLC) and D (GPI-PLD).
Regulation of carcinoembryonic antigen release from colorectal cancer cells.
Hosseini et al., Shīrāz, Iran. In Mol Biol Rep, 2012
We investigated if the rate of CEA and another GPI-anchored protein, alkaline phosphatase (AP) release is correlated with cellular glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) expression.
Genetic variation of GPLD1 associates with serum GPI-PLD levels: a preliminary study.
Pratt et al., Indianapolis, United States. In Biochim Biophys Acta, 2012
We and others have described a small (7.0nm), minor (0.1% of total apolipoprotein AI) particle containing apolipoprotein AI, AIV and glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in humans the function of which is not entirely known.
Discovery of a novel circulating biomarker in patients with abdominal aortic aneurysm: a pilot study using a proteomic approach.
Henriksson et al., Sundsvall, Sweden. In Clin Transl Sci, 2012
The most interesting finding was that patients with small AAA had increased levels of the enzyme glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) compared with the controls without aneurysm.
Plasma glycosylphosphatidylinositol phospholipase D (GPI-PLD) and abdominal aortic aneurysm.
Henriksson et al., Sundsvall, Sweden. In Int J Clin Exp Med, 2011
In a current proteomic pilot-study elevated levels of the enzyme Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) was shown in patients with small AAA compared with controls without aneurysm.
Effects of membrane cholesterol depletion and GPI-anchored protein reduction on osteoblastic mechanotransduction.
You et al., United States. In J Cell Physiol, 2011
Secondly, we used a novel approach to decrease the levels of GPI-anchored proteins on cell membranes by overexpressing glycosylphosphatidylinositol-specific phospholipase D in MC3T3-E1 osteoblastic cells.
Human and mouse mast cells express and secrete the GPI-anchored isoform of CD160.
Bensussan et al., Créteil, France. In J Invest Dermatol, 2011
Supporting this hypothesis, HMC-1 express the GPI-specific phospholipase D variant 2 involved in the NK lymphocyte membrane cleavage of CD160, and morphological studies highlighted a relative loss of CD160 expression in inflammatory skin sites, where MC degranulation is expected to occur.
Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells.
Parinandi et al., Columbus, United States. In Int J Toxicol, 2011
This study revealed the novel mechanism of bleomycin-induced redox-sensitive activation of phospholipase D leading to the generation of phosphaticid acid.
An essential role for phospholipase D in the recruitment of vesicle amine transport protein-1 to membranes in human neutrophils.
Bourgoin et al., Québec, Canada. In Biochem Pharmacol, 2011
The role of phospholipase D in the transport of VAT1 to plasma membranes and in phosphatidic acid metabolism in neutrophils is reported.
Glycosylphosphatidylinositol-specific phospholipase D improves glucose tolerance.
Deeg et al., Indianapolis, United States. In Metabolism, 2010
Overexpressing GPI-PLD in an insulinoma cell line enhanced glucose-stimulated insulin secretion, suggesting that enhanced insulin secretion in vivo may have contributed to the improved glucose tolerance.
[Expression and activity of glycosylphosphatidylinositol-specific phospholipase d mRNA in bone marrow mononuclear cells isolated from patient with acute myeloid leukemia and their significance].
Zeng et al., Changsha, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010
The mRNA expression and activity of GPI-PLD in de novo and refractory or relapsed acute myeloid leukemia patients are obviously higher than those in normal controls.
Important roles of glycosylphosphatidylinositol (GPI)-specific phospholipase D and some GPI-anchored proteins in the pathogenesis of hepatocellular carcinoma.
Zhu et al., Changsha, China. In Clin Biochem, 2009
The serum GPI-PLD activities, the protein and mRNA levels of GPI-PLD in hepatocellular carcinoma patients were decreased by 40%, 60% and 56%, respectively.
Wnt signaling is regulated by endoplasmic reticulum retention.
Peterson et al., United States. In Plos One, 2008
Finally, we address the mechanism of Oto-mediated Wnt retention under oto-abundant conditions, by cotransfecting Wnt1 with gpi-specific phospholipase D (GPI-PLD).
Proteins anchored via glycosylphosphatidylinositol and solubilizing phospholipases in Trypanosoma cruzi.
Heise et al., São Paulo, Brazil. In Biol Res, 1992
Previously unreported resistance to glycosylphosphatidylinositol-specific phospholipase D has been observed both to glycosylphosphatidylinositol-specific phospholipase D has been observed both to 1G7-Ag and 10D8-Ag, the GPI-anchored mucynlike protein which is acceptor of sialic acid in metacyclic forms.
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