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Glycerol-3-phosphate dehydrogenase 2

GPD2, mitochondrial glycerophosphate dehydrogenase, mGPDH, GPDM
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: GPD1, Insulin, ACID, Presenilin-1, V1a
Papers on GPD2
Increasing Anaerobic Acetate Consumption and Ethanol Yields in Saccharomyces cerevisiae with NADPH-Specific Alcohol Dehydrogenase.
Zelle et al., United States. In Appl Environ Microbiol, Jan 2016
We show that an industrial bioethanol strain engineered with the original pathway (expressing acetylating acetaldehyde dehydrogenase from Bifidobacterium adolescentis and with deletions of glycerol-3-phosphate dehydrogenase genes GPD1 and GPD2) consumed 1.9 g liter(-1) acetate during fermentation of 114 g liter(-1) glucose.
Short-term response of different Saccharomyces cerevisiae strains to hyperosmotic stress caused by inoculation in grape must: RT-qPCR study and metabolite analysis.
Garcia-Moruno et al., Asti, Italy. In Food Microbiol, Dec 2015
We have implemented an RT-qPCR (Reverse Transcription-quantitative PCR) methodology with a preventive evaluation of candidate reference genes, to study six target genes related to glycerol synthesis (GPD1, GPD2, GPP2 and GPP1) and flux (STL1 and FPS1), and three ALD genes coding for aldehyde dehydrogenase involved in redox equilibrium via acetate production.
Metabolic engineering and adaptive evolution for efficient production of D-lactic acid in Saccharomyces cerevisiae.
Hahn et al., Seoul, South Korea. In Appl Microbiol Biotechnol, Dec 2015
In addition, ethanol production was reduced by deleting PDC1 and ADH1 genes encoding major pyruvate decarboxylase and alcohol dehydrogenase, respectively, and glycerol production was eliminated by deleting GPD1 and GPD2 genes encoding glycerol-3-phosphate dehydrogenase.
Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways.
Scott et al., Melbourne, Australia. In Oncotarget, Dec 2015
Global proteomic profiling of xenograft tumours (in presence of cetuximab, bevacizumab, and combination treatments) revealed alterations in proteins involved in glucose, lipid and fatty acid metabolism (e.g., GPD2, ATP5B, STAT3, FASN), as well as hypoxic regulators and vasculogenesis (e.g., ATP5B, THBS1, HSPG2).
Identifying and assessing the impact of wine acid-related genes in yeast.
Bauer et al., Stellenbosch, South Africa. In Curr Genet, Jul 2015
Genes selected in this manner were ADH3, AAD6, SER33, ICL1, GLY1, SFC1, SER1, KGD1, AGX1, OSM1 and GPD2.
Molecular action of metformin in hepatocytes: an updated insight.
Drzewoski et al., Łódź, Poland. In Curr Diabetes Rev, 2014
The reduction of gluconeogenesis evoked by metformin may be a result of an energy deficit evoked through the inhibition of mitochondrial respiratory chain complex I and/or increased cytosolic redox state and decreased mitochondrial redox state elicited by the inhibition of mitochondrial glycerophosphate dehydrogenase (mGPD).
Immobilization of phosphate monomers on collagen induces biomimetic mineralization.
Tagami et al., San Francisco, United States. In Biomed Mater Eng, 2014
METHODS: Three functional monomers (MDP, GPDM and Phenyl-P) that differed in chemical structure and steric hindrances around the phosphate moiety were evaluated.
[Effects of overexpression of NADH kinase gene on ethanol fermentation by Saccharomyces cerevisiae].
Shi et al., In Sheng Wu Gong Cheng Xue Bao, 2014
In order to improve ethanol yield and the substrate conversion, a cassette about 4.5 kb for gene homologous recombination, gpd2Δ::PGK1(PT)-POS5-HyBR, was constructed and transformed into the haploid strain S. cerevisiae S1 (MATa) to replace the GPD2 gene by POS5 gene.
Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice.
Lu et al., Winston-Salem, United States. In Redox Biol, 2014
Inner mitochondrial membrane peptidase 2-like (IMMP2L) protein is a mitochondrial inner membrane peptidase that cleaves the signal peptide sequences of cytochrome c1 (CYC1) and mitochondrial glycerol phosphate dehydrogenase (GPD2).
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Shulman et al., New Haven, United States. In Nature, 2014
Here we show that metformin non-competitively inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase, resulting in an altered hepatocellular redox state, reduced conversion of lactate and glycerol to glucose, and decreased hepatic gluconeogenesis.
NADH-dependent biosensor in Saccharomyces cerevisiae: principle and validation at the single cell level.
Gorwa-Grauslund et al., Lund, Sweden. In Amb Express, 2013
A reporter system was constructed to measure perturbations in the NADH/NAD(+) co-factor balance in yeast, by using the green fluorescent protein gene under the control of the GPD2 promoter that is induced under conditions of excess of NADH.
The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues.
Houštěk et al., Praha, Czech Republic. In Biochim Biophys Acta, 2013
Mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) is not included in the traditional textbook schemes of the respiratory chain, reflecting the fact that it is a non-standard, tissue-specific component of mammalian mitochondria.
Chronic leptin treatment inhibits liver mitochondrial alpha-glycerol-beta-phosphate dehydrogenase in euthyroid rats.
Lisboa et al., Rio de Janeiro, Brazil. In Horm Metab Res, 2007
These results show that leptin downregulates mGPD activity, mainly when hyperleptinemia is chronic.
Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer.
Singh et al., Hamilton, Canada. In Free Radic Res, 2007
the up-regulation of mGPDH, due to a highly glycolytic environment, contributes to the overall increase in ROS generation and may result in the progression of prostate cancer
High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines.
Singh et al., Hamilton, Canada. In Biochem Biophys Res Commun, 2005
Overall, these data demonstrate that mGPDH is involved in maintaining a high rate of glycolysis and is an important site of electron leakage leading to ROS production in prostate cancer cells.
[Role of the NADH shuttle system in glucose-induced insulin secretion].
Kadowaki et al., Tokyo, Japan. In Nihon Rinsho, 1999
To determine the role of the NADH shuttle system composed of the glycerol phosphate shuttle and malate-aspartate shuttle in glucose-induced insulin secretion from pancreatic beta cells, we have generated mice which lack mitochondrial glycerol-3 phosphate dehydrogenase (mGPDH), a rate-limiting enzyme of the glycerol phosphate shuttle.
Transcription factor abnormalities as a cause of beta cell dysfunction in diabetes: a hypothesis.
Bonner-Weir et al., Boston, United States. In Acta Diabetol, 1997
These include a loss of GLUT2, glycogen accumulation, glucose recycling, abnormal glucokinase or hexokinase, altered mitochondrial glycerol phosphate dehydrogenase (mGPDH) activity, abnormal ion channel function and beta cell degranulation.
Physiology, pathology and pharmacology of insulin secretion: recent acquisitions.
Malaisse, Brussels, Belgium. In Diabetes Metab, 1997
Pathological considerations concern mainly the possible participation of an inherited or acquired defect of FAD-linked mitochondrial glycerophosphate dehydrogenase in the impairment of insulin release in non-insulin-dependent diabetes.
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