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Nucleoporin 210kDa

gp210, gp190
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PBC, Sp100, CD45, Phosphogluconate Dehydrogenase, HAD
Papers on gp210
Assessment of health related quality of life in polish patients with primary biliary cirrhosis.
Milkiewicz et al., Warsaw, Poland. In Clin Res Hepatol Gastroenterol, Dec 2015
Anti-gp210 positive, as well as AMA negative PBC patients, had worse HRQoL features in itch and social/emotional domains of PBC-40/PBC-27 questionnaires.
Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis.
Ishibashi et al., Ōmura, Japan. In Hepatol Res, Aug 2015
RESULTS: Anti-gp210 positivity and a higher bile duct loss score were significant risk factors for worse alkaline phosphatase (ALP) response (odds ratios [OR], 2.78 and 1.85, respectively).
The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis.
Hetzer et al., San Diego, United States. In J Cell Biol, Apr 2015
Previously, we identified the nucleoporin gp210/Nup210 as a critical regulator of muscle and neuronal differentiation, but how this nucleoporin exerts its function and whether it modulates nuclear pore complex (NPC) activity remain unknown.
Microscopic polyangiitis associated with primary biliary cirrhosis, Sjogren's syndrome and Hashimoto's thyroiditis.
Houman et al., Tunis, Tunisia. In Saudi J Kidney Dis Transpl, Mar 2015
Detection of antinuclear antibodies at a titer of 1/800, anti-SSA, anti-SSB, anti-GP210, anti-microsomial and p-ANCA anti-myeloperoxydase antibodies along with renal, salivary and liver biopsy led to a diagnosis of MPA associated with PBC, Sjogren's syndrome and Hashimoto's thyroiditis.
Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis.
Gershwin et al., San Diego, United States. In Liver Int, Feb 2015
Not only are both markers highly specific for PBC (≥95%) but they also yielded higher sensitivity than anti-gp210 and anti-sp100 antibodies.
Autoantibodies in Chinese patients with chronic hepatitis B: prevalence and clinical associations.
Mao et al., Beijing, China. In World J Gastroenterol, Feb 2015
The AIH-related autoantibody profile included homogeneous anti-nuclear antibodies (ANA-H), smooth-muscle antibodies, anti-liver kidney microsome type 1, anti-liver cytosolic antigen type 1, and anti-soluble liver antigen/liver pancreas; the PBC-related antibodies were characterized by ANA-nuclear dots/membranous rim-like, anti-mitochondrial antibodies-M2 (AMA-M2), anti-BPO (recombinant antigen targeted by AMA-M2), anti-Sp100, anti-promyelocytic leukemia protein (anti-PML), and anti-gp210.
CellProfiler: Novel Automated Image Segmentation Procedure for Super-Resolution Microscopy.
Soliman, Göttingen, Germany. In Biol Proced Online, 2014
We tested this method and succeeded to segment individual nuclear pore complexes stained with gp210 and pan-FG proteins and captured by two-color STED microscopy.
An autoimmune myositis-overlap syndrome associated with autoantibodies to nuclear pore complexes: description and long-term follow-up of the anti-Nup syndrome.
Dabauvalle et al., Montréal, Canada. In Medicine (baltimore), 2014
The nuclear pore complex proteins, that is, nucleoporins (nup), recognized by these sera were heterogeneous and included Nup358/RanBP2 (n = 2 patients), Nup90 (n = 1), Nup62 (n = 1), and gp210 (n = 1).
Clinical significance of autoantibodies in primary biliary cirrhosis.
Nakamura, Ōmura, Japan. In Semin Liver Dis, 2014
Antimitochondrial, anti-gp210, anti-sp100, and anticentromere antibodies are specifically detected in primary biliary cirrhosis (PBC).
Primary biliary cirrhosis in adults.
Lindor et al., Lexington, United States. In Expert Rev Gastroenterol Hepatol, 2014
Certain findings such as fatigue, anti-nuclear antibodies, anti-centromere antibodies and the GP210 antinuclear antibody predict a poor outcome.
High levels of soluble CTLA-4 are present in anti-mitochondrial antibody positive, but not in antibody negative patients with primary biliary cirrhosis.
Bizzaro et al., Genova, Italy. In Plos One, 2013
sCTLA-4 presence was associated with autoantibodies against MIT3, but not with nuclear autoantibodies (sp100, gp210).
Primary biliary cirrhosis and the nuclear pore complex.
Gershwin et al., Davis, United States. In Autoimmun Rev, 2012
Autoantibodies against the integral membrane glycoprotein gp210 and nucleoporin p62 appear to be highly specific for PBC, an autoimmune disease characterized by progressive destruction of intrahepatic biliary epithelial cells.
Antinuclear antibodies as ancillary markers in primary biliary cirrhosis.
Muratori et al., Bologna, Italy. In Expert Rev Mol Diagn, 2012
The target antigens of the multiple nuclear dots pattern have been identified as Sp100 and promyelocytic leukemia protein, whereas the rim-like/membranous pattern is given by autoantibodies recognizing multiple proteins such as gp210, nucleoporin p62 and the lamin B receptor.
Risk factors and prediction of long-term outcome in primary biliary cirrhosis.
Nakamura et al., Japan. In Intern Med, 2010
Notably, based on our analyses accelerated progression to jaundice and liver failure are reflected by a sustained serologic presence of anti-gp210 antibodies whereas patients with portal hypertension in the absence of jaundice have anti-centromere autoantibodies.
Phosphomimetic mutation of the mitotically phosphorylated serine 1880 compromises the interaction of the transmembrane nucleoporin gp210 with the nuclear pore complex.
Hallberg et al., Huddinge, Sweden. In Exp Cell Res, 2007
These findings are consistent with the idea that mitotic phosphorylation acts to dissociate gp210 from the structural elements of the nuclear pore complexes.
Nuclear pore complex assembly and maintenance in POM121- and gp210-deficient cells.
Görlich et al., Heidelberg, Germany. In J Cell Biol, 2006
Double knockdowns of gp210 in HeLa cells suggest that nuclear pore complexes can assemble or at least persist in a gp210-free form.
Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis.
Ishibashi et al., Ōmura, Japan. In J Autoimmun, 2006
The increased expression of gp210 in small bile ducts is possibly involved in autoimmune response to gp210 leading to the progression to end-stage hepatic failure in primary biliary cirrhosis .
Antibody titer to gp210-C terminal peptide as a clinical parameter for monitoring primary biliary cirrhosis.
Ishibashi et al., Ōmura, Japan. In J Hepatol, 2005
Quantitation of serusm anti-gp210-C-terminal peptide antibodies is useful for monitoring the effect of ursodeoxycholic acid and for the early identification of patients at high risk for end-stage hepatic failure.
Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210.
Ekblom et al., Lund, Sweden. In J Negat Results Biomed, 2003
WT1 is probably not regulating GP210 expression, in spite of binding sites for WT1
Epitopes recognized by human T cells map within the conserved part of the GP190 of P. falciparum.
Bujard et al., Heidelberg, Germany. In Science, 1988
In a study aimed at developing a vaccine against the asexual blood stages of Plasmodium falciparum, two T cell epitopes were identified within a nonpolymorphic region of gp190 of Plasmodium falciparum merozoites.
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