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Gonadotropin-releasing hormone 1

Gonadotropin-Releasing Hormone, GnRH, LHRH
The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH), also known as gonadoliberin-1, and prolactin release-inhibiting factor, also known as GnRH-associated peptide 1. LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: kisspeptin, CAN, HAD, V1a, FSH
Papers using Gonadotropin-Releasing Hormone antibodies
Interferon-α is involved in the luteinizing hormone-induced differentiation of rat preovulatory granulosa cells
Salumets Andres et al., In Clinical and Developmental Immunology, 2008
... Ovarian hormonal stimulation was conducted according to a protocol of gonadotrophin-releasing hormone (GnRH) antagonist (Cetrotide; Merck Serono, Geneva, Switzerland) administered ...
Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty
Park Mi Jung et al., In Korean Journal of Pediatrics, 2004
... GnRH-green fluorescent protein tagged mice (Transgenic GnRH-EGFP-mut5) were housed under ...
Differential activation of the luteinizing hormone β-subunit promoter by activin and gonadotrophin-releasing hormone: a role for the mitogen-activated protein kinase signaling pathway in LβT2 gonadotrophs
McNeilly A S et al., In The Journal of Endocrinology, 2003
... 50 ng/ml recombinant human activin A (R&D Systems, Abingdon, Oxon, UK) ±a daily 1-h pulse of 10 nM GnRH (Bachem, St Helens, Merseyside, UK), ...
[The monomer electronic spectra and fluorescence spectra of some metal phthalocyanines].
Monleon Daniel, In PLoS ONE, 1999
... Side chain protected GnRH peptide (50 mg, 0.015 mmol) on Wang resin (GL Biochem Ltd., Shanghai, China) was ...
Life history variation in a population of the Australian frog Ranidella signifera: egg size and early development
Brodie Edmund D et al., In Ecology and Evolution, 1988
... Each female was injected with 10 μl luteinizing hormone releasing hormone ([des-Gly10, D-His(Bzl)6]-LHRH ethylamide; Sigma #L2761, Sigma Aldrich, St ...
Papers on Gonadotropin-Releasing Hormone
Neural and neuroendocrine processing of a non-photic cue in an opportunistically-breeding songbird.
Bentley et al., Berkeley, United States. In J Exp Biol, Feb 2016
It has been hypothesized that an increase in DIO2 and reciprocal decrease in DIO3 causes the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, setting off a reproductive cascade, and that this DIO mechanism for GnRH release is conserved across vertebrate taxa.
BMP-6 modulates somatostatin effects on luteinizing hormone production by gonadrotrope cells.
Makino et al., Okayama, Japan. In Peptides, Feb 2016
LH mRNA expression and LH secretion induced by GnRH were suppressed by treatments with somatostatin analogs, including octreotide and pasireotide, in LβT2 cells.
GnRH and GnRH receptors in the pathophysiology of the human female reproductive system.
Limonta et al., Milano, Italy. In Hum Reprod Update, Jan 2016
BACKGROUND: Human reproduction depends on an intact hypothalamic-pituitary-gonadal (HPG) axis.
Persistent GnRH receptor activation in pituitary αT3-1 cells analyzed with a label-free technology.
Heitman et al., Leiden, Netherlands. In Biosens Bioelectron, Jan 2016
UNASSIGNED: The gonadotropin-releasing hormone (GnRH) receptor is a drug target for certain hormone-dependent diseases such as prostate cancer.
Ghrelin action on GnRH neurons and pituitary gonadotropes might be mediated by GnIH-GPR147 system.
Celik et al., In Horm Mol Biol Clin Investig, Jan 2016
UNASSIGNED: Acylated ghrelin (AG) effect on GnRH secretion is mediated, at least in part, by GH secreta-gogue receptor (GHS-R) which is present in the GnRH neurons.
Differential testosterone response to GnRH-induced LH release before and after musth in adult Asian elephant (Elephas maximus) bulls.
Thitaram et al., Chiang Mai, Thailand. In Theriogenology, Jan 2016
UNASSIGNED: Bull elephants exhibit marked increases in testosterone secretion during musth, and studies have shown a heightened sensitivity of the testis to GnRH-stimulated testosterone production in musth compared to nonmusth males.
GABAergic regulation of the HPA and HPG axes and the impact of stress on reproductive function.
Maguire et al., Boston, United States. In J Steroid Biochem Mol Biol, Jan 2016
UNASSIGNED: The hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes are regulated by GABAergic signaling at the level of corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GnRH) neurons, respectively.
Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era.
Crowley et al., Boston, United States. In Endocr Rev, Dec 2015
The neuroendocrine regulation of reproduction is an intricate process requiring the exquisite coordination of an assortment of cellular networks, all converging on the GnRH neurons.
Therapeutic Neuroendocrine Agonist and Antagonist Analogs of Hypothalamic Neuropeptides as Modulators of the Hypothalamic-Pituitary-Gonadal Axis.
Millar et al., In Endocr Dev, Dec 2015
Gonadotropin-releasing hormone (GnRH) synthesized in the hypothalamus stimulates the secretion of gonadotropins which in turn stimulate gonadal sex hormone production and gamete formation.
Combined Labelled and Label-free SERS Probes for Triplex Three-dimensional Cellular Imaging.
Hu et al., Wuhan, China. In Sci Rep, Dec 2015
The SERS technique is used for a stereoscopic description of the intrinsic chemical nature of nuclei and the precise localization of folate (FA) and luteinizing hormone-releasing hormone (LHRH) on the membrane under highly confocal conditions.
The pre-vertebrate origins of neurogenic placodes.
Levine et al., Berkeley, United States. In Nature, Sep 2015
The Ciona PPE is shown to produce ciliated neurons that express genes for gonadotropin-releasing hormone (GnRH), a G-protein-coupled receptor for relaxin-3 (RXFP3) and a functional cyclic nucleotide-gated channel (CNGA), which suggests dual chemosensory and neurosecretory activities.
Patient-reported outcomes with adjuvant exemestane versus tamoxifen in premenopausal women with early breast cancer undergoing ovarian suppression (TEXT and SOFT): a combined analysis of two phase 3 randomised trials.
Walley et al., Bern, Switzerland. In Lancet Oncol, Jul 2015
Gonadotropin-releasing hormone analogue triptorelin, bilateral oophorectomy, or bilateral ovarian irradiation were used to achieve OFS.
Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy.
POEMS/S0230 Investigators et al., Sydney, Australia. In N Engl J Med, Apr 2015
Studies of the use of gonadotropin-releasing hormone (GnRH) agonists to protect ovarian function have shown mixed results and lack data on pregnancy outcomes.
Dissecting the Roles of Gonadotropin-Inhibitory Hormone in Mammals: Studies Using Pharmacological Tools and Genetically Modified Mouse Models.
Tena-Sempere et al., Córdoba, Spain. In Front Endocrinol (lausanne), 2014
Among the central regulators of reproduction, kisspeptins, as major stimulatory drivers of gonadotropin-releasing hormone (GnRH) neurosecretion, have drawn considerable interest in the last decade.
Central precocious puberty caused by mutations in the imprinted gene MKRN3.
Kaiser et al., Boston, United States. In N Engl J Med, 2013
BACKGROUND: The onset of puberty is first detected as an increase in pulsatile secretion of gonadotropin-releasing hormone (GnRH).
Neonatal dexamethasone exposure down-regulates GnRH expression through the GnIH pathway in female mice.
Parhar et al., Malaysia. In Neuroscience, 2012
the results show that the delayed pubertal onset could be due to the inhibition of GnRH gene expression after neonatal DEX treatment
GnRH regulation of Jun and Atf3 requires calcium, calcineurin, and NFAT.
Nilson et al., Pullman, United States. In Mol Endocrinol, 2012
Data suggest that calcineurin and NFAT4 (NFATC transcription factor 4) are required for maximal accumulation of mRNA for proto-oncogenes c-Jun and c-Fos in gonadotropes in response to GnRH.
Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons.
Kuehl-Kovarik et al., Columbia, United States. In Brain Res, 2012
Aging appears to modulate not only depolarizing afterpotential amplitude, but the effect of in vivo estradiol on sodium currents in GnRH neurons.
Signaling of cytokines is important in regulation of GnRH neurons.
Wolfe et al., Baltimore, United States. In Mol Neurobiol, 2012
The role of several class 1 cytokines in regulating GnRH neuronal development, GnRH secretion, and GnRH expression in this REVIEW.
Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling.
Kauffman et al., San Diego, United States. In Endocrinology, 2012
It was concluded that elevated testosterone secretion in prenatal and neonatal mice is independent of both kisspeptin and GnRH signaling, and the necessity of kisspeptin-Kiss1r signaling for testicular function is first apparent after d 5.
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