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Leucine-rich repeat containing G protein-coupled receptor 6

gonadotropin receptor
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HCG, FSH, HAD, ACID, FSHR
Papers on gonadotropin receptor
miRNA-592 is downregulated and may target LHCGR in polycystic ovary syndrome patients.
Li et al., China. In Reprod Biol, Dec 2015
Furthermore, we found that miR-592 was inversely correlated with the level of luteinizing hormone/chorionic gonadotropin receptor (LHCGR).
A new variant in signal peptide of the human luteinizing hormone receptor (LHCGR) affects receptor biogenesis causing leydig cell hypoplasia.
Bonomi et al., Cusano Milanino, Italy. In Hum Mol Genet, Dec 2015
The human luteinizing hormone/chorionic gonadotropin receptor (LHCGR) plays a fundamental role in male and female reproduction.
High levels of testosterone inhibit ovarian follicle development by repressing the FSH signaling pathway.
Chen et al., Jinan, China. In J Huazhong Univ Sci Technolog Med Sci, Oct 2015
The combined effects of testosterone and follicle-stimulating hormone (FSH) on follicular growth and granulosa cell gonadotropin receptor mRNA expression were also investigated.
miR-122 Regulates LH Receptor Expression by Activating Sterol Response Element Binding Protein in Rat Ovaries.
Menon et al., Ann Arbor, United States. In Endocrinology, Sep 2015
LH/human chorionic gonadotropin receptor (LHR) undergoes down-regulation during preovulatory LH surge or in response to exposure to a supraphysiological concentration of its ligands through a posttranscriptional mechanism involving an RNA binding protein designated as LHR mRNA binding protein (LRBP).
Human chorionic gonadotropin stimulates spheroid attachment on fallopian tube epithelial cells through the mitogen-activated protein kinase pathway and down-regulation of olfactomedin-1.
Lee et al., Hong Kong, Hong Kong. In Fertil Steril, Aug 2015
MAIN OUTCOME MEASURE(S): Luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and Olfm1 expression in fallopian tube epithelium cell line (OE-E6/E7 cells).
Molecular aspects of bovine cystic ovarian disease pathogenesis.
Salvetti et al., Ithaca, United States. In Reproduction, Jun 2015
The evidence also shows that gonadotropin receptor expression in bovine cystic follicles is altered, which suggests that changes in the signaling system of gonadotropins could play a fundamental role in the pathogenesis of conditions characterized by altered ovulation, such as COD.
Genetic Models for the Study of Luteinizing Hormone Receptor Function.
Narayan, Carbondale, United States. In Front Endocrinol (lausanne), 2014
The luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is essential for fertility in men and women.
Assessing Gonadotropin Receptor Function by Resonance Energy Transfer-Based Assays.
Reiter et al., France. In Front Endocrinol (lausanne), 2014
Gonadotropin receptors belong to the super family of G protein-coupled receptors and mediate the physiological effects of follicle-stimulating hormone (FSHR) and luteinizing hormone (LHR).
Transgenic mice expressing inhibin α-subunit promoter (inhα)/Simian Virus 40 T-antigen (Tag) transgene as a model for the therapy of granulosa cell-derived ovarian cancer.
Rahman et al., Turku, Finland. In Reprod Biol, 2014
When we aimed at targeted destruction of luteinizing hormone/chorionic gonadotropin receptor (LHCGR) expressing inhα/Tag tumor cells in vivo by a lytic peptide Hecate-CGβ conjugate, we could successfully kill the tumor cells, sparing the normal cells.
Constitutive activity in gonadotropin receptors.
Huhtaniemi et al., Tours, France. In Adv Pharmacol, 2013
In this chapter, we summarize the structural features, functional consequences, and mechanisms that lead to constitutive activation of gonadotropin receptor CAMs and provide information on pharmacological approaches that might potentially modulate gonadotropin receptor CAM function.
Polymorphisms in gonadotropin and gonadotropin receptor genes as markers of ovarian reserve and response in in vitro fertilization.
Simoni et al., Reggio nell'Emilia, Italy. In Fertil Steril, 2013
Since gonadotropins are the fundamental hormones that control ovarian activity, genetic polymorphisms may alter gonadal responsiveness to glycoproteins; hence they are important regulators of hormone activity at the target level.
Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.
Huhtaniemi et al., Rotterdam, Netherlands. In Endocr Rev, 2000
Both activating and inactivating mutations have been detected in the gonadotropin receptor genes, a larger number in the LH receptor gene, but so far only a few in the gene for the FSH receptor.
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility.
Matzuk et al., Houston, United States. In Nat Genet, 1997
Minimal data has been accumulated so far involving human mutations in the FSH beta, LH beta, or the gonadotropin receptor genes.
On the structure of the luteinizing hormone/chorionic gonadotropin receptor.
Segaloff et al., New York City, United States. In Endocr Rev, 1989
In this review we have tried to argue that the evidence indicating that the LH/CG receptor is composed of a single polypeptide is stronger than the evidence indicating that the LH/CG receptor is a more complex structure composed of several subunits.
Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.
Schomberg et al., In Science, 1981
Epidermal growth factor and fibroblast growth factor inhibited follicle-stimulating hormone-dependent induction of luteinizing hormone receptor in cultured ovarian granulosa cells of the rat.
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