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Glucocorticoid modulatory element binding protein 2

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, CREB, CBP
Papers on GMEB-2
Both genes and lncRNAs can be used as biomarkers of prostate cancer by using high throughput sequencing data.
Yan et al., Linhai, China. In Eur Rev Med Pharmacol Sci, 2014
RESULTS: A total of 7112 DEGs were screened, such as ZNF512B, UCKL1, STMN3, GMEB2, and PTK6.
IL-12 inhibits glucocorticoid-induced T cell apoptosis by inducing GMEB1 and activating PI3K/Akt pathway.
Constantinescu et al., Nottingham, United Kingdom. In Immunobiology, 2012
Here, we confirm that IL-12 rescue of dexamethasone induced T cell apoptosis involves the PI3K/Akt pathway and that IL-12 induces GMEB1 and GMEB2.
Differential modulation of glucocorticoid and progesterone receptor transactivation.
Simons et al., Bethesda, United States. In Mol Cell Endocrinol, 2008
The current study demonstrates that other factors known to modulate GR properties (GME, GMEB-2, Ubc9, and STAMP) can also differentially interact with PRs or alter several of the above induction parameters under otherwise identical conditions.
Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex.
Simons et al., Bethesda, United States. In Biochemistry, 2004
Here, we report the structure/activity relationships of GMEB-2 and compare them to our previous findings for GMEB-1.
Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions.
Scheffzek et al., Heidelberg, Germany. In Mol Endocrinol, 2003
The glucocorticoid-modulatory element-binding proteins, GMEB1 and GMEB2, are ubiquitous, multifunctional DNA-binding proteins with important roles in the modulation of transcription upon steroid hormone activation.
A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters.
Tattersall et al., New Haven, United States. In J Mol Biol, 2002
consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters
Ability of the glucocorticoid modulatory element to modify glucocorticoid receptor transactivation indicates parallel pathways for the expression of glucocorticoid modulatory element and glucocorticoid response element activities.
Simons et al., Bethesda, United States. In Mol Cell Endocrinol, 2000
The expression of GME activity involves the binding of two novel proteins (GMEB-1 and GMEB-2) that we have recently cloned.
Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins.
Simons et al., Bethesda, United States. In Nucleic Acids Res, 2000
The glucocorticoid modulatory element binding proteins 1 and 2 (GMEB-1 and GMEB-2) are of interest both for their multiple activities (e.g.
Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family.
Gronemeyer et al., Illkirch-Graffenstaden, France. In Febs Lett, 2000
BLAST analysis revealed that the identified cDNA encodes a KDWK domain and contains sequences almost identical to three tryptic peptides of rat GMEB-1 which together with the GMEB-2 heterodimeric partner binds to the GME/CRE sequence (glucocorticoid modulatory element) of the tyrosine aminotransferase (TAT) promoter.
Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein.
Landry et al., Qu├ębec, Canada. In Febs Lett, 1999
A 21-bp element called glucocorticoid modulatory element (GME) modulates the glucocorticoid receptor-mediated responses via the binding of an as yet poorly characterized transacting complex of proteins containing the 88-kDa GMEB1 and the 67-kDa GMEB2.
Cloning and characterization of a novel binding factor (GMEB-2) of the glucocorticoid modulatory element.
Simons et al., Bethesda, United States. In J Biol Chem, 1998
The longer 2.0-kilobase pair cDNA encoded an open reading frame for an acidic, 529-amino acid protein and afforded a major 67-kDa and a minor 58-kDa protein after in vitro transcription/translation. Both proteins were recognized by a mono-epitopic antibody raised against a peptide of GMEB-2.
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