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Thyroid hormone receptor interactor 11

GMAP-210, TRIP11, Trip230, CEV14
This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CIs, V1a, CAN, ARF1, ARF GAP
Papers using GMAP-210 antibodies
The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi
Munro Sean et al., In The Journal of Cell Biology, 2001
... - and COOH-terminal fragments of human GMAP-210 were expressed in a vector containing a cytomegalovirus promoter, an SV40 origin of replication (CLONTECH Laboratories, Inc.), and myc-GMAP-210 ...
Papers on GMAP-210
Interactome analysis reveals that FAM161A, deficient in recessive retinitis pigmentosa, is a component of the Golgi-centrosomal network.
Rivolta et al., Lausanne, Switzerland. In Hum Mol Genet, Jul 2015
Notable FAM161A interactors included AKAP9, FIP3, GOLGA3, KIFC3, KLC2, PDE4DIP, NIN and TRIP11.
The golgin GMAP-210 is required for efficient membrane trafficking in the early secretory pathway.
Lowe et al., Manchester, United Kingdom. In J Cell Sci, May 2015
Previous studies on the golgin GMAP-210 (also known as TRIP11), which is mutated in the rare skeletal disorder achondrogenesis type 1A, have yielded conflicting results regarding its involvement in trafficking.
Coupling of vesicle tethering and Rab binding is required for in vivo functionality of the golgin GMAP-210.
Lowe et al., Manchester, United Kingdom. In Mol Biol Cell, Mar 2015
In this study, we show that depletion of the golgin GMAP-210 causes a loss of Golgi cisternae and accumulation of numerous vesicles.
Membrane Curvature Sensing by Amphipathic Helices Is Modulated by the Surrounding Protein Backbone.
Antonny et al., France. In Plos One, 2014
For instance, the ALPS motif of the golgin GMAP210 binds trafficking vesicles, while the ALPS motif of Nup133 targets nuclear pores.
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.
Tobin et al., London, United Kingdom. In Nat Commun, 2014
We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
A TRIP230-retinoblastoma protein complex regulates hypoxia-inducible factor-1α-mediated transcription and cancer cell invasion.
Beischlag et al., Canada. In Plos One, 2013
We demonstrated that Rb is a key mediator of the hypoxic response mediated by HIF1α/β, the master regulator of the hypoxia response, and its essential co-activator, the thyroid hormone receptor/retinoblastoma-interacting protein (TRIP230).
TRIP11-PDGFRB fusion in a patient with a therapy-related myeloid neoplasm with t(5;14)(q33;q32) after treatment for acute promyelocytic leukemia.
Koh et al., Chinju, South Korea. In Mol Cytogenet, 2013
Translocation of 5q31-33, PDGFRB occur rarely in therapy-related myeloid neoplasm and there has been two identified PDGFRB partner genes located at 14q32, TRIP11 and KIAA1509.
Golgi Feels Its Own Wound.
Jane et al., Australia. In Adv Wound Care (new Rochelle), 2013
This was achieved by Yadav et al. (2009) through depletion of Golgin-160 or GMAP210 (Golgi microtubule associated protein of 210 kDa), which resulted in fragmentation and dispersal of Golgi without altering secretion kinetics.
GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail.
Rios et al., New York City, United States. In Dev Dyn, 2011
Data show that IFT88 is present in the Golgi of spermatids, that the microtubule-associated golgin GMAP210 and IFT88 participate in acrosome, HTCA, and tail biogenesis.
Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210.
Beier et al., Boston, United States. In N Engl J Med, 2010
mice with lethal skeletal dysplasia had a nonsense mutation in the thyroid hormone receptor interactor 11 gene (Trip11), which encodes the Golgi microtubule-associated protein 210 (GMAP-210)
[Regulation of vesicular transport by membrane curvature].
Antonny et al., Antibes, France. In Med Sci (paris), 2009
We will discuss how the activity of ArfGAP1 and GMAP-210, two proteins involved in vesicular transport, is regulated by membrane curvature thanks to an ALPS motif.
The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.
Pazour et al., Worcester, United States. In Plos Genet, 2008
GMAP210 and IFT20 function together at the Golgi in the sorting of proteins destined for the ciliary membrane.
Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms.
Rios et al., Sevilla, Spain. In Bmc Biol, 2008
Localisation of GMAP-210 (TRIP11) to Golgi is the result of the combined action of two domains (N- and C-terminal) that recognize different sub-regions of the Golgi apparatus.
Asymmetric tethering of flat and curved lipid membranes by a golgin.
Antonny et al., Antibes, France. In Science, 2008
the attachment of golgin GMAP-210 to lipid membranes
Golgi positioning: are we looking at the right MAP?
Egerer et al., Martinsried, Germany. In J Cell Biol, 2005
Recent findings suggest that GMAP-210, a member of the golgin family of proteins, may help to link Golgi membranes and vesicles with the MT cytoskeleton.
Positioning the Golgi apparatus.
Linstedt, Pittsburgh, United States. In Cell, 2004
Ríos et al. (2004) report in this issue that the Golgi protein GMAP-210 is sufficient to confer pericentrosomal positioning and recruits gamma-tubulin and associated microtubule-nucleating ring complex proteins to Golgi membranes.
GMAP-210 recruits gamma-tubulin complexes to cis-Golgi membranes and is required for Golgi ribbon formation.
Bornens et al., Sevilla, Spain. In Cell, 2004
Here we show that GMAP-210, a cis-Golgi microtubule binding protein, recruits gamma-tubulin-containing complexes to Golgi membranes even in conditions where microtubule polymerization is prevented and independently of Golgi apparatus localization within the cell.
Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta.
Cross et al., Salisbury, United Kingdom. In Acta Haematol, 2001
PDGFRB is disrupted by other translocations and to date four additional partner genes (H4, HIP1, CEV14 and Rab5) have been reported.
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