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Duffy blood group, chemokine receptor

glycoprotein D, DARC, Duffy blood group antigen
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD45, CAN, HAD, HVEM, ACID
Papers on glycoprotein D
Deletion of a Predicted β-sheet Domain within the Amino-terminus of Herpes Simplex Virus Glycoprotein K (gK) Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons.
Kousoulas et al., Baton Rouge, United States. In J Virol, Jan 2016
In this assay, cell-surface bound virions were detected by the colocalization of glycoprotein D (gD) and its cognate receptor nectin-1 on infected neuronal surfaces.
Comprehensive red blood cell and platelet antigen prediction from whole genome sequencing: proof of principle.
MedSeq Project et al., Boston, United States. In Transfusion, Jan 2016
RESULTS: Some major differences and alignment issues were found when attempting to convert the conventional cDNA to human reference genome sequences for the following genes: ABO, A4GALT, RHD, RHCE, FUT3, ACKR1 (previously DARC), ACHE, FUT2, CR1, GCNT2, and RHAG.
Extensive Admixture and Selective Pressure Across the Sahel Belt.
Pereira et al., Porto, Portugal. In Genome Biol Evol, Dec 2015
The DARC gene region in Arabs and Nubians was enriched for African ancestry, whereas the RAB3GAP1/LCT/MCM6 region in Oromo, the TAS2R gene family in Fulani, and the ALMS1/NAT8 in Turkana and Samburu were enriched for non-African ancestry.
A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions.
Rayner et al., Bethesda, United States. In Plos Negl Trop Dis, Dec 2015
Only one ligand-receptor interaction has been identified, that between P. vivax Duffy Binding Protein (PvDBP) and the erythrocyte Duffy Antigen Receptor for Chemokines (DARC), and strain-specific immune responses to PvDBP make it a complex vaccine target.
Non-Canonical (RANKL-Independent) Pathways of Osteoclast Differentiation and Their Role in Musculoskeletal Diseases.
Athanasou et al., Oxford, United Kingdom. In Clin Rev Allergy Immunol, Dec 2015
These humoral factors can generally be divided into those which, like RANKL, are tumour necrosis family (TNF) superfamily members and those which are not; the former include TNFα lymphotoxin exhibiting inducible expression and competing with herpes simplex virus glycoprotein D for herpesvirus entry mediator, a receptor expressed by T lymphocytes (LIGHT), a proliferation inducing ligand (APRIL) and B cell activating factor (BAFF); the latter include transforming growth factor beta (TGF-β), interleukin-6 (IL-6), IL-8, IL-11, nerve growth factor (NGF), insulin-like growth factor-I (IGF-I) and IGF-II.
Tumor necrosis factor superfamily in innate immunity and inflammation.
Ware et al., Los Angeles, United States. In Cold Spring Harb Perspect Biol, Apr 2015
The TNFSF and TNFRSF proteins lymphotoxins, LIGHT (homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for herpes virus entry mediator [HVEM], a receptor expressed by T lymphocytes), lymphotoxin-β receptor (LT-βR), and HVEM are used by embryonic and adult innate lymphocytes to promote the development and homeostasis of lymphoid organs.
Improving immunogenicity and efficacy of vaccines for genital herpes containing herpes simplex virus glycoprotein D.
Friedman et al., Philadelphia, United States. In Expert Rev Vaccines, 2014
The focus of genital herpes vaccine trials has been on prevention using herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) alone or combined with glycoprotein B. These prevention trials did not achieve their primary end points.
Development and evaluation of the quantitative real-time PCR assay in detection and typing of herpes simplex virus in swab specimens from patients with genital herpes.
Zhang et al., Beijing, China. In Int J Clin Exp Med, 2014
In this study, to evaluate the significance of the real-time PCR method in diagnosis and typing of genital HSV, the primers and probes targeted at HSV-1 DNA polymerase gene and HSV-2 glycoprotein D gene fraction were designed and applied to amplify DNA from HSV-1 or HSV-2 by employing the real-time PCR technique.
The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon.
Carvalho et al., Belo Horizonte, Brazil. In Mem Inst Oswaldo Cruz, 2014
Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC).
Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology.
van Drunen Littel-van den Hurk et al., Rio Grande, Brazil. In Vet Res, 2013
The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and -5), two important pathogens of cattle, is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses.
Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens.
Sattentau et al., Oxford, United Kingdom. In Nat Biotechnol, 2012
A single intranasal administration of influenza hemagglutinin or herpes simplex virus type-2 (HSV-2) glycoprotein D with PEI elicited robust antibody-mediated protection from an otherwise lethal infection, and was superior to existing experimental mucosal adjuvants.
DARC alleles and Duffy phenotypes in African Americans.
Flegel et al., Bethesda, United States. In Transfusion, 2012
We developed a phylogenetic tree for DARC alleles and postulated a distinct FY*B allele as ancestral for the extant DARC alleles in humans.
Bivariate genome-wide association study suggests that the DARC gene influences lean body mass and age at menarche.
Deng et al., Shanghai, China. In Sci China Life Sci, 2012
Data suggest that DARC (Duffy antigen receptor for chemokines) gene may play an important role in regulating the metabolisms of both lean body mass (LBM) and age at menarche (AAM).
The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.
National Heart et al., San Francisco, United States. In Chest, 2012
Our results provide evidence that the functional rs2814778 polymorphism in the gene encoding DARC is associated with worse clinical outcomes among African Americans with ALI, possibly via an increase in circulating IL-8.
Efficacy results of a trial of a herpes simplex vaccine.
Herpevac Trial for Women et al., Saint Louis, United States. In N Engl J Med, 2012
BACKGROUND: Two previous studies of a herpes simplex virus type 2 (HSV-2) subunit vaccine containing glycoprotein D in HSV-discordant couples revealed 73% and 74% efficacy against genital disease in women who were negative for both HSV type 1 (HSV-1) and HSV-2 antibodies.
Fy(a)/Fy(b) antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria.
Zimmerman et al., Cleveland, United States. In Proc Natl Acad Sci U S A, 2012
findings show that Fy(a), compared with Fy(b), significantly diminishes binding of Pv Duffy binding protein (PvDBP) at the erythrocyte surface, and is associated with a reduced risk of clinical Plasmodium vivax in humans
The genetics of benign neutropenia.
Ziv et al., Israel. In Isr Med Assoc J, 2011
Here we describe the recent success in mapping the gene that underlies benign neutropenia in African American populations. We discuss the known function of the gene and consider potential mechanisms for the effect on neutropenia.[review]
CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection.
Worthen et al., Philadelphia, United States. In Immunity, 2010
The chemokine sink hypothesis pertaining to erythrocyte Duffy Antigen Receptor for Chemokines (DARC) during inflammation has received considerable attention, but lacks direct in vivo evidence.
Slow down and survive: Enigmatic immunoregulation by BTLA and HVEM.
Murphy et al., Saint Louis, United States. In Annu Rev Immunol, 2009
The BTLA-HVEM interaction is intriguing and quite complex given that HVEM has four other ligands that also influence immune responses, the conventional TNF ligand LIGHT and lymphotoxin alpha, as well as herpes simplex virus glycoprotein D and the glycosylphosphatidylinositol-linked Ig domain protein CD160.
Evolution of a malaria resistance gene in wild primates.
Wray et al., United States. In Nature, 2009
Here, we report on the functional consequences of genetic variation at the malaria-related FY (DARC) gene in a well-studied population of yellow baboons (Papio cynocephalus) living in Amboseli National Park in Kenya.
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