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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Progestagen-associated endometrial protein

glycodelin, PP14, placental protein 14, GdA, GDF, glycodelin A
This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. A number of alternatively spliced transcript variants have been observed at this locus, but the full-length nature of only two, each encoding the same protein, has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, GDF9, GDF5, HAD, TGF-beta
Papers on glycodelin
Comparison of Inflammatory Biomarkers in Outpatients With Prior Myocardial Infarction.
Ikeda et al., Chinju, South Korea. In Int Heart J, Feb 2016
We enrolled 430 post-MI patients and measured their levels of high-sensitivity C reactive protein (hs-CRP), growth differentiation factor-15 (GDF-15), and the interleukin-1 receptor family member called ST2 (ST2), one month after AMI.
The Pleiotropic Effect of Glycodelin-A in Early Pregnancy.
Chiu et al., Hong Kong, Hong Kong. In Am J Reprod Immunol, Feb 2016
Glycodelin-A is a glycoprotein abundant in the decidua during early pregnancy.
Control of glioma cell migration and invasiveness by GDF-15.
Roth et al., Zürich, Switzerland. In Oncotarget, Feb 2016
UNASSIGNED: Growth and differentiation factor (GDF)-15 is a member of the transforming growth factor (TGF)-β family of proteins.
Adenovirus-mediated GDF-5 promotes the extracellular matrix expression in degenerative nucleus pulposus cells.
Feng et al., Nanchong, China. In J Zhejiang Univ Sci B, Jan 2016
OBJECTIVE: To construct a recombinant adenovirus vector-carrying human growth and differentiation factor-5 (GDF-5) gene, investigate the biological effects of adenovirus-mediated GDF-5 (Ad-GDF-5) on extracellular matrix (ECM) expression in human degenerative disc nucleus pulposus (NP) cells, and explore a candidate gene therapy method for intervertebral disc degeneration (IDD).
Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors.
Chavakis et al., Philadelphia, United States. In Curr Opin Hematol, Jan 2016
Furthermore, several endogenous inhibitory mechanisms of leukocyte recruitment have been identified, including the secreted molecules Del-1, PTX3, and GDF-15, which block distinct steps of the leukocyte adhesion cascade, as well as novel regulatory signaling pathways, involving the protein kinase AKT1 and IFN-λ2/IL-28A.
Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells.
García-Velasco et al., Madrid, Spain. In Eur J Obstet Gynecol Reprod Biol, Jan 2016
Main outcome measures were growth-differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15) expression, hormonal profile and apoptosis rate.
Inflammatory biomarkers predicting prognosis in patients with acute dyspnea.
Melander et al., Lund, Sweden. In Am J Emerg Med, Dec 2015
(P = 2.5 × 10(-8)) and for growth differentiation factor-15 (GDF-15) was 3.45 (2.18-5.45)
Diabetes mellitus related biomarker: The predictive role of growth-differentiation factor-15.
Berezin, Ukraine. In Diabetes Metab Syndr, Nov 2015
UNASSIGNED: Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine, which belongs to super family of the transforming growth factor beta. GDF-15 is widely presented in the various cells (macrophages, vascular smooth muscle cells, adipocytes, cardiomyocytes, endothelial cells, fibroblasts), tissues (adipose tissue, vessels, tissues of central and peripheral nervous system) and organs (heart, brain, liver, placenta) and it plays an important role in the regulation of the inflammatory response, growth and cell differentiation.
Generation and periodontal differentiation of human gingival fibroblasts-derived integration-free induced pluripotent stem cells.
Luan et al., Beijing, China. In Biochem Biophys Res Commun, Nov 2015
Furthermore, treatment of the iPSCs in vitro with enamel matrix derivative (EMD) or growth/differentiation factor-5 (GDF-5) significantly up-regulated the expression of periodontal tissue markers associated with bone, periodontal ligament and cementum respectively.
Overview of Transforming Growth Factor β Superfamily Involvement in Glioblastoma Initiation and Progression.
Lin et al., Taipei, Taiwan. In Asian Pac J Cancer Prev, 2014
The transforming growth factor β (TGFβ) superfamily is a large group of structurally related proteins including TGFβ subfamily members Nodal, Activin, Lefty, bone morphogenetic proteins (BMPs) and growth and differentiation factor (GDF).
Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway.
Yeung et al., Hong Kong, Hong Kong. In J Biol Chem, 2011
GdA interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK/c-Jun signaling pathway.
Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure.
Brown et al., Houston, United States. In Endocr Rev, 2011
BMP7, growth differentiation factor (GDF) 8, and GDF3 are versatile in their mechanisms of action, and altering their normal expression characteristics has significant effects on adiposity in vivo.
Glycodelin in endometrial flushing fluid and endometrial biopsies from infertile and fertile women.
Sørensen et al., Copenhagen, Denmark. In Eur J Obstet Gynecol Reprod Biol, 2011
At ovulation (day LH + 1), glycodelin concentration is increased in endometrium (and thus in endometrial flushing fluid) of infertile women with abnormal fallopian tubes compared to fertile controls.
GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice.
Wollert et al., Hannover, Germany. In Nat Med, 2011
Growth differentiation factor-15 (GDF-15), a transforming growth factor-β (TGF-β)-related cytokine, is induced in the infarcted heart of mice and humans.
Differential actions of glycodelin-A on Th-1 and Th-2 cells: a paracrine mechanism that could produce the Th-2 dominant environment during pregnancy.
Yeung et al., Hong Kong, Hong Kong. In Hum Reprod, 2011
GdA (not GdC, GdS, or deglycosylated GdA) up-regulates expression of Fas, suppresses MAPK signaling, and enhances cell death in isolated Th-1 cells (but not Th-2 cells). These data suggest GdA may contribute to Th-2/Th-1 shift as seen in pregnancy.
Insulin-like growth factor binding protein-1 and glycodelin levels in uterine flushing before and after hysteroscopic polypectomy.
Shalaby et al., Az Zaqāzīq, Egypt. In Clin Lab, 2010
Preoperative glycodelin is lower in patients with uterine polyps than in menorrhagia, but increase postoperatively. This could explain the pathophysiological mechanisms for impaired endometrial receptivity in the presence of endometrial polyps.
Association between glycodelin and aryl hydrocarbon receptor in Iranian breast cancer patients: impact of environmental endocrine disrupting chemicals.
Akbarzadeh et al., Tehrān, Iran. In Asian Pac J Cancer Prev, 2010
A significant association between tumoral levels of glycodelin and AhR (p=0.002) in breast cancers.
Bacterial gene amplification: implications for the evolution of antibiotic resistance.
Andersson et al., Uppsala, Sweden. In Nat Rev Microbiol, 2009
Recent data suggest that, in response to the presence of antibiotics, gene duplication and amplification (GDA) constitutes an important adaptive mechanism in bacteria.
A bifunctional bacterial protein links GDI displacement to Rab1 activation.
Isberg et al., Boston, United States. In Science, 2007
Here, we found that SidM from Legionella pneumophila could act as both GEF and GDI-displacement factor (GDF) for Rab1.
Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation.
Milgrom et al., Helsinki, Finland. In Endocr Rev, 2002
Glycodelin-A potently and dose-dependently inhibits human sperm-egg binding, whereas differently glycosylated glycodelin-S from seminal plasma has no such effect.
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