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Glycerol kinase

glycerol kinase, glycerokinase
The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, Insulin, V1a
Papers on glycerol kinase
Improvement in Oil Production by Increasing Malonyl-CoA and Glycerol-3-Phosphate Pools in Scenedesmus quadricauda.
Chung et al., South Korea. In Indian J Microbiol, Dec 2015
To increase intracellular oil content, yeast-derived genes encoding acetyl-CoA carboxylase (ACC1), glycerol kinase (GPD1), and glycerol-3-phosphate dehydrogenase (GUT1) were overexpressed under the control of CaMV 35S and NOS promoters with SV40 large T antigen components.
Epistasis effects of multiple ancestral-consensus amino acid substitutions on the thermal stability of glycerol kinase from Cellulomonas sp. NT3060.
Inagaki et al., Okayama, Japan. In J Biosci Bioeng, Nov 2015
NT3060 glycerol kinase have been constructed by through the introduction of ancestral-consensus mutations.
Heat stress enhances adipogenic differentiation of subcutaneous fat depot-derived porcine stromovascular cells.
Ajuwon et al., In J Anim Sci, Aug 2015
Expressions of HS genes such as heat shock proteins (HSP; HSP27, HSP60, HSP70, and HSP90), adipogenic markers peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer binding proteins α (C/EBPα), fatty acid synthase (FAS), adipocyte protein 2 (aP2), fatty acid translocase 36 (CD36), fatty acid transport protein 4 (FATP4), fatty acid transport protein 6 (FATP6), LPL, glucose transporter protein type 4 (GLUT4), phosphoenolpyruvate carboxykinase 1 (PCK1 or PEPCK-C), and glycerol kinase (GK) and adipokines (adiponectin and leptin) were determined by real-time-PCR and immunoblotting or ELISA.
Xp21 deletion in female patients with intellectual disability: Two new cases and a review of the literature.
Chantot-Bastaraud et al., Paris, France. In Eur J Med Genet, Jun 2015
Xp21 continuous gene deletion syndrome is characterized by complex glycerol kinase deficiency (GK), adrenal hypoplasia congenital (NROB1), intellectual disability and/or Duchenne muscular dystrophy (DMD).
Inborn errors of cytoplasmic triglyceride metabolism.
Mitchell et al., Montréal, Canada. In J Inherit Metab Dis, 2015
Two inborn errors of glycerol metabolism are known: glycerol kinase (GK, causing pseudohypertriglyceridemia) and glycerol-3-phosphate dehydrogenase (GPD1, childhood hepatic steatosis).
Hypertriglyceridaemia unresponsive to multiple treatments.
Moriarty et al., Kansas City, United States. In Bmj Case Rep, 2014
These findings suggest isolated asymptomatic glycerol kinase deficiency (GKD) or 'pseudohypertriglyceridaemia'.
Use of Enzymatic Biosensors to Quantify Endogenous ATP or H2O2 in the Kidney.
Staruschenko et al., United States. In J Vis Exp, 2014
The permselectivity layer protects the signal from the interferents in biological tissue, and the enzymatic layer utilizes the sequential catalytic reaction of glycerol kinase and glycerol-3-phosphate oxidase in the presence of ATP to produce H2O2.
Diabetes and infections-hepatitis C: is there type 2 diabetes excess in hepatitis C infection?
Maung et al., Kuala Lumpur, Malaysia. In Curr Diab Rep, 2013
PPARα upregulates glycerol-3-phosphate dehydrogenase, glycerol kinase, and glycerol transport proteins, which allows for glucose synthesis during fasting states.
Dicer partner proteins tune the length of mature miRNAs in flies and mammals.
Zamore et al., Worcester, United States. In Cell, 2012
The longer form of miR-307a represses glycerol kinase and taranis mRNA expression.
Intragenic deletions of IL1RAPL1: Report of two cases and review of the literature.
Moog et al., Heidelberg, Germany. In Am J Med Genet A, 2011
IL1RAPL1 (interleukin-1 receptor accessory protein-like 1) located at Xp21.3-22.1 has repeatedly been shown to be deleted in patients with a contiguous gene syndrome also affecting neighboring genes, in particular DMD (dystrophin), DAX-1 (NR0B1, nuclear receptor subfamily 0, group B, member 1), and GK (glycerol kinase).
The diagnostic difficulties of complex glycerol kinase deficiency.
Wilmshurst et al., Cape Town, South Africa. In J Child Neurol, 2010
Two siblings with the contiguous X-linked gene deletion syndrome, complex glycerol kinase deficiency, are described. The elder sibling demonstrates the difficulties diagnosing this rare condition.
Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells.
Dipple et al., Los Angeles, United States. In Metab Eng, 2010
This systems biology approach further emphasizes glucose kinase's essential role in central and lipid metabolism and experimentally verifies lucose kinase's alternative function of affecting glucocorticoid receptor transcription factor activity.
Asymptomatic isolated human glycerol kinase deficiency associated with splice-site mutations and nonsense-mediated decay of mutant RNA.
Dipple et al., Los Angeles, United States. In Pediatr Res, 2006
Results suggest that influences on RNA processing and protein stability represent modifiers of the glycerol kinase deficiency phenotype.
Human and murine glycerol kinase: influence of exon 18 alternative splicing on function.
McCabe et al., Los Angeles, United States. In Biochem Biophys Res Commun, 2005
Comparison of expression patterns, as well as enzymatic characteristics and subcellular localization of alternatively spliced glycerol kinase isoforms.
Characterization of the human glycerol kinase promoter: identification of a functional HNF-4alpha binding site and evidence for transcriptional activation.
Dipple et al., Los Angeles, United States. In Mol Genet Metab, 2003
a functional HNF-4alpha binding site in the first 500 bp of the 5(') upstream region is important for increased levels of glycerol kinase expression
A futile metabolic cycle activated in adipocytes by antidiabetic agents.
Lazar et al., Philadelphia, United States. In Nat Med, 2002
Here we report that TZDs, acting as ligands for the nuclear receptor peroxisome proliferator-activated receptor (PPAR)-gamma, markedly induce adipocyte glycerol kinase (GyK) gene expression.
Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.
Rabl et al., Oxford, United Kingdom. In Nature, 1995
AHC can occur as a part of a contiguous deletion syndrome together with Duchenne muscular dystrophy (DMD) and/or glycerol kinase deficiency (GKD).
Genomic scanning for expressed sequences in Xp21 identifies the glycerol kinase gene.
Wheeler et al., Houston, United States. In Nat Genet, 1993
We identified expressed sequences within a cosmid in the glycerol kinase (GK) "critical region" of Xp21 that had impressive similarity to prokaryotic GKs.
Structure of the regulatory complex of Escherichia coli IIIGlc with glycerol kinase.
Remington et al., Eugene, United States. In Science, 1993
The crystal structure at 2.6 A resolution of one of the targets, glycerol kinase (GK), in complex with unphosphorylated IIIGlc, glycerol, and adenosine diphosphate was determined.
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