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Glycerate kinase

glycerate kinase, Glyctk
This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Phospho, ACID, CAN, V1a, HAD
Papers on glycerate kinase
Genomic Analysis of Serogroup Y Neisseria meningitidis Isolates Reveals Extensive Similarities Between Carriage and Disease-Associated Organisms.
Turner et al., Nottingham, United Kingdom. In J Infect Dis, Feb 2016
These sub-clusters were defined by specific allelic differences in five core genes encoding glycerate kinase (glxK), valine-pyruvate transaminase (avtA), superoxide dismutase (sodB) and two hypothetical proteins.
An in vivo metabolic approach for deciphering the product specificity of glycerate kinase proves that both E. coli's glycerate kinases generate 2-phosphoglycerate.
Bar-Even et al., Israel. In Plos One, 2014
Along these lines, we developed an in vivo metabolic strategy that conclusively identifies the product specificity of glycerate kinase.
Differential protective effects of extra virgin olive oil and corn oil in liver injury: a proteomic study.
Wan et al., Wuhan, China. In Food Chem Toxicol, 2014
The proteomic study indicates that the protein expression of thioredoxin domain-containing protein 12, peroxiredoxin-1, thiosulphate sulphurtransferase, calcium-binding protein 1, Annexin A2 and heat shock cognate 71 kDa protein are higher in livers from EVOO-fed rats with the CCl4 treatment compared with those from rats fed with corn oil, whereas the expression of COQ9, cAMP-dependent protein kinase type I-alpha regulatory subunit, phenylalanine hydroxylase and glycerate kinase are lower.
Metabolic alterations in mammary cancer prevention by withaferin A in a clinically relevant mouse model.
Singh et al., Pittsburgh, United States. In J Natl Cancer Inst, 2013
Proteomics confirmed downregulation of many glycolysis-related proteins in the tumor of WA-treated mice compared with control, including M2-type pyruvate kinase, phospho glycerate kinase, and fructose-bisphosphate aldolase A isoform 2. CONCLUSIONS: This study reveals suppression of glycolysis in WA-mediated mammary cancer prevention in a clinically relevant mouse model.
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
Siebers et al., Essen, Germany. In Febs J, 2013
In order to address these questions two key enzymes of the branched ED pathway, the class II glycerate kinase (GK) of the np-ED branch and the 2-keto-3-deoxygluconate kinase (KDGK) of the sp-ED branch in S. solfataricus, were investigated.
Untargeted metabolome quantitative trait locus mapping associates variation in urine glycerate to mutant glycerate kinase.
Gauguier et al., Oxford, United Kingdom. In J Proteome Res, 2012
The most significant evidence of linkages were obtained with NMR signals characterizing the glycerate (LOD10-42) at the mutant glycerate kinase locus, which demonstrate the power of metabolomics in quantitative genetics to identify the biological function of genetic variants.
Evolution of enzymes involved in the photorespiratory 2-phosphoglycolate cycle from cyanobacteria via algae toward plants.
Hagemann et al., Rostock, Germany. In Photosynth Res, 2011
Three enzymes in eukaryotic phototrophs clustered closely with cyanobacterial homologs: glycolate oxidase, glycerate kinase, and hydroxypyruvate reductase.
Metabolomic analysis of normal (C57BL/6J, 129S1/SvImJ) mice by gas chromatography-mass spectrometry: detection of strain and gender differences.
Fei et al., Shanghai, China. In Talanta, 2011
We infer that a deficiency of d-glycerate kinase would explain such a glyceric acid accumulation in the 129S1/SvImJ strain.
D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK).
Walter et al., Freiburg, Germany. In Hum Mutat, 2010
Mutations in the GLYCTK gene is the cause of D-glycerate kinase deficiency and D-glyceric aciduria.
Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2.
Yu et al., Shanghai, China. In Dna Seq, 2006
Identification of two variants of the human glycerate kinase gene-Glycerate kinase 1 (GLYCTK1), longer variant, and Glycerate kinase 2 (GLYCTK2), shorter variant.
L-serine production by a methylotroph and its related enzymes.
Tanabe et al., Tottori, Japan. In Appl Microbiol Biotechnol, 1993
Since there has so far been little report on the systematic characterization of enzymes of the serine pathway in methylotrophs, not only the above two enzymes but also the other three enzymes in H. methylovorum were purified and characterized: MDH, SHMT and hydroxypyruvate reductase (HPR) were crystallized; serine-glyoxylate aminotransferase (SGAT) and glycerate kinase (GK) were purified to homogeneity.
An improved model of C3 photosynthesis at high CO2: Reversed O 2 sensitivity explained by lack of glycerate reentry into the chloroplast.
Sharkey et al., San Diego, United States. In Photosynth Res, 1991
In that case, phosphate normally used in the stromal glycerate kinase reaction to generate PGA from glycerate is made available for photophosphorylation, stimulating RuBP regeneration and assimilation.
Biochemical contribution to diagnosis and study of a new case of D-glyceric acidemia/aciduria.
Degand et al., Lille, France. In Clin Chem, 1989
After comparing all our results with those of the preceding observations described in the literature, we suggest a possible enzymatic defect located on one of the metabolic pathways shared by fructose and L-serine, possibly at the level of hepatic D-glycerate kinase (EC
Loose association of ribulose 1,5-bisphosphate carboxylase/oxygenase with chloroplast thylakoid membranes.
Akazawa et al., Nagoya, Japan. In Photosynth Res, 1984
P-glycerate kinase and aldolase also associated to the thylakoid membranes but NADP-linked glyceraldehyde-3-P dehydrogenase did not.
Regulation of glycolysis and level of the Crassulacean acid metabolism.
Queiroz et al., Gif-sur-Yvette, France. In Planta, 1979
Glycolysis shows different patterns of operation and different control steps, depending on whether the level of Crassulacean acid metabolism (CAM) is low or high in the leaves of Kalanchoe blossfeldiana v.Poelln., when subjected to appropriate photoperiodic treatments: at a low level of CAM operation all the enzymes of glycolysis and phosphoenol pyruvate (PEP) carboxylase present a 12 h rhythm of capacity, resulting from the superposition of two 24h rhythms out of phase; phosphofructokinase appears to be the main regulation step; attainment of high CAM level involves (1) an increase in the peak of capacity occurring during the night of all the glycolytic enzymes, thus achieving an over-all 24h rhythm, in strict allometric coherence with the increase in PEP carboxylase capacity, (2) the establishment of different phase relationships between the rhythms of enzyme capacity, and (3) the control of three enzymic steps (phosphofructokinase, the group 3-P-glyceraldehyde dehydrogenase - 3-P-glycerate kinase, and PEP carboxylase).
Uptake and reduction of glycerate by isolated chloroplasts.
Schäfer et al., Düsseldorf, Germany. In Planta, 1974
Chloroplasts contain activities of glycerate kinase which approximately correspond to observed glycerate reduction rates at light saturation.
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