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Glucosamine-phosphate N-acetyltransferase 1

Glucosamine 6-Phosphate N-Acetyltransferase, GNA1, glucosamine-6-phosphate acetyltransferase, EMeg32
Top mentioned proteins: Arylamine N-Acetyltransferase, CAN, ACID, fibrillin-1, V1a
Papers on Glucosamine 6-Phosphate N-Acetyltransferase
Modular pathway engineering of Bacillus subtilis for improved N-acetylglucosamine production.
Chen et al., Wuxi, China. In Metab Eng, 2014
First, two-promoter systems with different promoter types and strengths were used for combinatorial assembly of expression cassettes of glmS (encoding GlcN-6-phosphate synthase) and GNA1 (encoding GlcNAc-6-phosphate N-acetyltransferase) at transcriptional levels in the GlcNAc synthesis module, resulting in a 32.4% increase in GlcNAc titer (from 1.85g/L to 2.45g/L) in shake flasks.
Characterization of a UDP-N-acetylglucosamine biosynthetic pathway encoded by the giant DNA virus Mimivirus.
Tonetti et al., Genova, Italy. In Glycobiology, 2014
In this study, we have characterized three Mimivirus proteins involved in the de novo uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) production: a glutamine-fructose-6-phosphate transaminase (CDS L619), a glucosamine-6-phosphate N-acetyltransferase (CDS L316) and a UDP-GlcNAc pyrophosphorylase (CDS R689).
Pathway engineering of Bacillus subtilis for microbial production of N-acetylglucosamine.
Chen et al., Wuxi, China. In Metab Eng, 2013
Specifically, glmS (encoding GlcN-6-phosphate synthase) from B. subtilis 168 and GNA1 (encoding GlcNAc-6-phosphate N-acetyltransferase) from Saccharomyces cerevisiae S288C were firstly co-overexpressed in B. subtilis; the level of GlcNAc reached 240mg/L in shake flask culture.
Cell-free expression of human glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening.
Wang et al., Guangzhou, China. In Protein Expr Purif, 2012
Glucosamine 6-phosphate N-acetyltransferase (GNA1; EC
GNB3 C825T polymorphism is associated with postural tachycardia syndrome in children.
Tamai et al., Ōsaka, Japan. In Pediatr Int, 2012
In the GNAS1 T393C, the genotype frequencies for the T393C polymorphisms of GNA1 did not differ significantly between the groups.
Engineering of an N-acetylneuraminic acid synthetic pathway in Escherichia coli.
Qi et al., Jinan, China. In Metab Eng, 2012
In this pathway, N-acetylglucosamine 2-epimerase (slr1975) and glucosamine-6-phosphate acetyltransferase (GNA1) were heterologously introduced into E. coli from Synechocystis sp.
Genetic and physical interactions between Gα subunits and components of the Gβγ dimer of heterotrimeric G proteins in Neurospora crassa.
Borkovich et al., Riverside, United States. In Eukaryot Cell, 2012
Three Gα subunits (GNA-1, GNA-2, and GNA-3), one Gβ subunit (GNB-1), and one Gγ subunit (GNG-1) have been functionally characterized, but genetic epistasis relationships between Gβ and Gα subunit genes have not been determined.
A missense mutation in the glucosamine-6-phosphate N-acetyltransferase-encoding gene causes temperature-dependent growth defects and ectopic lignin deposition in Arabidopsis.
Sato et al., Japan. In Plant Cell, 2012
The lig mutation was identified as a single base transition in GNA1 encoding glucosamine-6-phosphate N-acetyltransferase (GNA), a critical enzyme of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis.
Structural and biochemical characterization of a trapped coenzyme A adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1.
van Aalten et al., Dundee, United Kingdom. In Acta Crystallogr D Biol Crystallogr, 2012
Glucosamine-6-phosphate N-acetyltransferase 1 (GNA1) produces GlcNAc-6-phosphate from GlcN-6-phosphate and acetyl coenzyme A. Early mercury-labelling experiments implicated a conserved cysteine in the reaction mechanism, whereas recent structural data appear to support a mechanism in which this cysteine plays no role.
Crystal structure and functional characterization of a glucosamine-6-phosphate N-acetyltransferase from Arabidopsis thaliana.
Usadel et al., Potsdam, Germany. In Biochem J, 2012
GNA (glucosamine-6-phosphate N-acetyltransferase) catalyses the second of these four reactions in the de novo synthesis in eukaryotes.
[Influence of nagE and manX knockout with red homologous recombination on the microbial production of glucosamine by Escherichia coli].
Chen et al., Wuxi, China. In Sheng Wu Gong Cheng Xue Bao, 2012
To alleviate or block the transportation process, nagE gene (encoding for the GlcNAc-specific transporter) and manX gene (encoding for the mannose transporter) were knocked out with the Red homologous recombination method, and two engineered strains, E. coli-glms-gna1-delta nagE (with nagE gene deletion) and E. coli-glms-gna1-delta nagE-delta manX (with nagE and manX genes deletion), were successfully constructed.
The guanine nucleotide exchange factor RIC8 regulates conidial germination through Gα proteins in Neurospora crassa.
Borkovich et al., Riverside, United States. In Plos One, 2011
We have previously demonstrated that the non-receptor guanine nucleotide exchange factor RIC8 acts upstream of the Gα proteins GNA-1 and GNA-3 to regulate hyphal extension.
RIC8 is a guanine-nucleotide exchange factor for Galpha subunits that regulates growth and development in Neurospora crassa.
Borkovich et al., Riverside, United States. In Genetics, 2011
In Neurospora, deletion of ric8 leads to profound defects in growth and asexual and sexual development, similar to those observed for a mutant lacking the Gα genes gna-1 and gna-3.
Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.
Ferguson et al., Dundee, United Kingdom. In Eukaryot Cell, 2011
A gene predicted to encode Trypanosoma brucei glucosamine 6-phosphate N-acetyltransferase (TbGNA1; EC
Acceptor substrate binding revealed by crystal structure of human glucosamine-6-phosphate N-acetyltransferase 1.
Su et al., Beijing, China. In Febs Lett, 2008
Crystal structures of human GNA1, including apo GNA1, the GNA1-GlcN6P complex and an E156A mutant were reported.
Structure and functions of the GNAT superfamily of acetyltransferases.
Blanchard et al., United States. In Arch Biochem Biophys, 2005
These include aminoglycoside N-acetyltransferases, serotonin N-acetyltransferase, glucosamine-6-phosphate N-acetyltransferase, the histone acetyltransferases, mycothiol synthase, protein N-myristoyltransferase, and the Fem family of amino acyl transferases.
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