GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Glucagon, Glucagon-Like Peptide 1, GLP-1
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008] (from
Pozzilli et al., Bari, Italy. In Diabetes Metab Res Rev, Feb 2016
In this review, the options for treatment intensification will be explored, focusing on drug classes that act via the incretin system and paying particular attention to the short-acting glucagon-like peptide-1 receptor agonist lixisenatide.
Madsbad et al., Copenhagen, Denmark. In Am J Physiol Endocrinol Metab, Feb 2016
UNASSIGNED: Exaggerated secretion of glucagon-like peptide 1 (GLP-1) is important for postprandial glucose tolerance after Roux-en-Y gastric bypass (RYGB), whereas the role of glucose-dependent insulinotropic polypeptide (GIP) remains to be resolved.
Wittmann et al., Pécs, Hungary. In Curr Med Chem, Feb 2016
High-cholesterol feeding lead to a significant increase in aortic wall meta-tyrosine content and a decreased vasorelaxation of the aorta to insulin and the glucagon-like peptide-1 analogue, liraglutide, that both could be prevented by administration of para-tyrosine.
Skibicka et al., Göteborg, Sweden. In J Neurosci, 2012
A novel neurobiological mechanism is demonstrated for GLP-1-induced anorexia in rats, involving direct effects of a GLP-1 analogue, Exendin-4 (EX4) on food reward that are exerted at the level of the mesolimbic reward system.