Evidence for time dependent variation of glucagon secretion in mice.
Lund, Sweden. In Peptides, Feb 2016
We therefore examined glucagon secretion after meal ingestion (meal tolerance test) and during hypoglycemia (hyperinsulinemic hypoglycemia clamp at 2.5mmol/l glucose) and in vitro from isolated islets at ZT3 versus ZT15 in normal C57BL/6J mice and, furthermore, glucose levels and the insulin response to meal ingestion were also examined at these time points in glucagon receptor knockout mice (GCGR-/-) and their wildtype (wt) littermates.
The galectin lattice at a glance.
Toronto, Canada. In J Cell Sci, Aug 2015
The galectin lattice also regulates the selection, activation and arrest of T cells, receptor kinase signaling and the functionality of membrane receptors, including the glucagon receptor, glucose and amino acid transporters, cadherins and integrins.
Recent Advances in Synthetic Chemistry of Diabetic Research.
Rio de Janeiro, Brazil. In Mini Rev Med Chem, 2014
Extensive research has been carried out using rational drug design to identify and optimize new leads for molecular targets of T2DM, which include Heterocyclic compounds, metal complexes, H3 receptor antagonists, glucagon receptor antagonists and human incretin-degrading enzyme dipeptidyl peptidase IV inhibitors.
International Union of Pharmacology. XXXV. The glucagon receptor family.
Evanston, United States. In Pharmacol Rev, 2003
Peptide hormones within the secretin-glucagon family are expressed in endocrine cells of the pancreas and gastrointestinal epithelium and in specialized neurons in the brain, and subserve multiple biological functions, including regulation of growth, nutrient intake, and transit within the gut, and digestion, energy absorption, and energy assimilation.