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GLI pathogenesis-related 1

GLIPR1, GLIPR, RTVP-1, mRTVP-1, Glioma pathogenesis-related protein 1
This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p53, HAD, ACID, CAN, AP-1
Papers on GLIPR1
Genomic profiling of invasive melanoma cell lines by array comparative genomic hybridization.
Balázs et al., Debrecen, Hungary. In Melanoma Res, Jan 2016
Invasive primary cell lines showed high frequencies of CNAs, including the loss of 7q and gain of 12q chromosomal regions targeting PTPN12, ADAM22, FZD1, TFPI2, GNG11, COL1A2, SMURF1, VGF, RELN and GLIPR1 genes.
Role of the anti-glioma drug AT13148 in the inhibition of Notch signaling pathway.
Liu et al., Shanghai, China. In Gene, Dec 2015
A total of 122 DEGs were found to be potential drug targets for glioma, among which GLIPR1 was targeted by drug XL820, PDGFRB and KDR were targeted by SOT-107.
RTVP-1 promotes mesenchymal transformation of glioma via a STAT-3/IL-6-dependent positive feedback loop.
Brodie et al., Ramat Gan, Israel. In Oncotarget, Oct 2015
We explored the role of RTVP-1, a glioma-associated protein that promotes glioma cell migration, in the mesenchymal transformation of GBM.
RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK.
Brodie et al., Ramat Gan, Israel. In Oncotarget, Sep 2015
RTVP-1 is highly expressed in GBM and regulates the migration and invasion of glioma cells.
Testosterone regulates thyroid cancer progression by modifying tumor suppressor genes and tumor immunity.
Kebebew et al., Frederick, United States. In Carcinogenesis, Apr 2015
Mechanistically, less advanced cancer in castrated males was due to increased expression of tumor suppressor (Glipr1, Sfrp1) and immune-regulatory genes and higher tumor infiltration with M1 macrophages and CD8 cells.
Potential therapeutic mechanism of genistein in breast cancer involves inhibition of cell cycle regulation.
Diao et al., Chengdu, China. In Mol Med Report, Mar 2015
The most significant function and pathway of the DEGs in the overlapping network was the cell cycle involving several genes, including GLIPR1, CDC20, BUB1, MCM2 and CCNB1.
Whole genome expression profiling in chewing-tobacco-associated oral cancers: a pilot study.
Saranath et al., Mumbai, India. In Med Oncol, Mar 2015
The biological functions and representative deregulated genes include cell proliferation (AIM2, FAP, TNFSF13B, TMPRSS11A); signal transduction (FOLR2, MME, HTR3B); invasion and metastasis (SPP1, TNFAIP6, EPHB6); differentiation (CLEC4A, ELF5); angiogenesis (CXCL1); apoptosis (GLIPR1, WISP1, DAPL1); and immune responses (CD300A, IFIT2, TREM2); and metabolism (NNMT; ALDH3A1).
Genome-Wide Association Study for Autism Spectrum Disorder in Taiwanese Han Population.
Gau et al., Taipei, Taiwan. In Plos One, 2014
Results of the fine-mapping study showed single-marker associations in the GLIS1 (rs12082358 and rs12080993) and NAALADL2 (rs3914502 and rs2222447) genes, and gene-based associations for the OR2M3-OR2T5 (olfactory receptor genes, p = 0.02), and GLIPR1/KRR1 gene regions (p = 0.015).
SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1.
Yunes et al., Campinas, Brazil. In Plos One, 2014
Early cellular effects activated by SB225002 included the up-regulation of GLIPR1, a p53-target gene shown to have pro-apoptotic activities in prostate and bladder cancer.
GLIPR1-ΔTM synergizes with docetaxel in cell death and suppresses resistance to docetaxel in prostate cancer cells.
Thompson et al., Houston, United States. In Mol Cancer, 2014
The aim of this study was to evaluate the hypothesis that the combination treatment with docetaxel and GLIPR1-ΔTM will synergistically induce greater cell death and inhibit the emergence of resistance and development of metastatic potential in prostate cancer (PCa) cells.
Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma.
Toren et al., Ramat Gan, Israel. In Oncol Lett, 2014
Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV).
GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction.
Thompson et al., Houston, United States. In Cancer Res, 2012
Data show that the expression of GLIPR1 and c-Myc were inversely correlated in prostate cancer.
RTVP-1 expression is regulated by SRF downstream of protein kinase C and contributes to the effect of SRF on glioma cell migration.
Brodie et al., Ramat Gan, Israel. In Cell Signal, 2011
RTVP-1 plays a role in the effect of serum response factor on glioma cell migration
Identification of GLIPR1 tumor suppressor as methylation-silenced gene in acute myeloid leukemia by microarray analysis.
Xiao et al., Changsha, China. In J Cancer Res Clin Oncol, 2011
demonstrate that GLIPR1 is a methylation-silenced gene in the acute myeloid leukemia patients
Structural studies of human glioma pathogenesis-related protein 1.
Bonafé et al., Omaha, United States. In Acta Crystallogr D Biol Crystallogr, 2011
GLIPR1 core structure has a conserved central cavity via which CAP proteins are likely to bind to shared ligands.
Expression, purification, crystallization and preliminary X-ray analysis of a truncated soluble domain of human glioma pathogenesis-related protein 1.
Asojo et al., New Haven, United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010
X-ray data have been collected to beyond 1.9 A resolution from a crystal of GLIPR1 that belonged to the orthorhombic space group P2(1)2(1)2 with average unit-cell parameters a = 85.1, b = 79.5, c = 38.9 A and either a monomer or dimer
Glioma pathogenesis-related protein 1: tumor-suppressor activities and therapeutic potential.
Thompson, Houston, United States. In Yonsei Med J, 2010
After glioma pathogenesis-related protein 1 (GLIPR1/Glipr1) was identified, the expression of GLIPR1 was shown to be down-regulated in human prostate cancer, owing in part to methylation in the regulatory region of this gene in prostate cancer cells.
The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense.
O'Bryan et al., Australia. In Endocr Rev, 2008
The nine subfamilies of the mammalian CAP superfamily include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins.
Gene-modified bone marrow cell therapy for prostate cancer.
Thompson et al., Houston, United States. In Gene Ther, 2008
Finally, we discuss future directions in the development of gene-modified cell therapy for metastatic prostate cancer, including the need to identify and test novel therapeutic genes such as GLIPR1.
The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer.
Lawler et al., Dublin, Ireland. In Endocr Relat Cancer, 2008
The most significant advances have involved the discovery of apoptotic gene targets of methylation, including XAF1, (fragile histidine triad (FHIT ), cellular retinol binding protein 1 (CRBP1), decoy receptor 1(DCR1), decoy receptor 2 (DCR2 ), target of methylation-induced silenceing 1 (TMS1), TNF receptor superfamily, member 6 (FAS), Reprimo (RPRM) and GLI pathogenesis-related 1 (GLIPR1).
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