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Glial cells missing homolog 1

Glide, Gcm1, GCMa, Gcm2
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, SET, OUT, HAD, V1a
Papers on Glide
The basal chorionic trophoblast cell layer: An emerging coordinator of placenta development.
Schmidt-Ott et al., Berlin, Germany. In Bioessays, Feb 2016
Gcm1-positive cell clusters within this layer initiate branching morphogenesis thereby guiding allantoic fetal blood vessels towards maternal blood sinuses.
Glioma-associated oncogene-2 is essential for trophoblastic fusion by forming a transcriptional complex with Glial cell missing-a.
Wu et al., Tokyo, Japan. In J Biol Chem, Feb 2016
Finally, GLI2 not only stabilized Glial cell missing-a (GCMa), a pivotal transcriptional factor for trophoblastic syncytialization, but also formed a transcriptional heterodimer with GCMa to transactivate syncytin-1, a trophoblastic fusogen, and promote trophoblastic syncytialization.
An integrated molecular modeling approach for in silico design of new tetracyclic derivatives as ALK inhibitors.
Manga et al., Hyderābād, India. In J Recept Signal Transduct Res, Feb 2016
Initially docking was performed using GLIDE 5.6 to probe the bioactive conformation of all the compounds and to understand the binding modes of inhibitors.
[Combined Use of a Videolaryngoscope and a Transilluminating Device for Intubation with Two Difficult Airways].
Okuda et al., In Masui, Oct 2015
Laryngoscopy using a blade 3 of a Glide-Scope® (Laerdal Medical Corporation, New York, NY, USA) videolaryngoscope (GVL) showed a Cormack-Lehanne grade 3 view.
Development of Selective Lamellar Keratoplasty within an Asian Corneal Transplant Program: The Singapore Corneal Transplant Study (An American Ophthalmological Society Thesis).
Khor et al., Singapore, Singapore. In Trans Am Ophthalmol Soc, Sep 2015
Our surgical modifications to big-bubble deep anterior lamellar keratoplasty (DALK) surgery resulted in visual outcomes matching PK, and a low conversion to PK of 2.1%, whereas our evolving approaches to donor insertion in Descemet's stripping automated endothelial keratoplasty (DSAEK) show significant reduction in 1-year postoperative endothelial cell loss rates from 60% (folding), to 22% to 30% (Sheets Glide), to 15% (EndoGlide inserter).
Airway management during cardiopulmonary resuscitation.
Benger et al., Bristol, United Kingdom. In Curr Opin Crit Care, Jun 2015
A prospective observational study showed that the Glide Scope videolaryngoscope was associated with a first-pass success rate of 93%, with no differences between less and more experienced physicians.
Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease.
Grover et al., In Bmc Bioinformatics, 2014
The binding affinity of NFV with wild type HIV-PR was very high with a Glide XP docking score of -9.3 Kcal/mol.
Potential Broad Spectrum Inhibitors of the Coronavirus 3CLpro: A Virtual Screening and Structure-Based Drug Design Study.
Gamieldien et al., Cape Town, South Africa. In Viruses, 2014
The ZINC drugs-now library was screened in a consensus high-throughput pharmacophore modeling and molecular docking approach by Vina, Glide, GOLD and MM-GBSA.
The potential impact of the fetal genotype on maternal blood pressure during pregnancy.
Dunger et al., Cambridge, United Kingdom. In J Hypertens, 2014
Other risk may be associated with imprinted fetal growth genes and genes that are highly expressed in the placenta such as GCM1.
High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion.
Chen et al., Taipei, Taiwan. In Mol Cell Biol, 2012
study reveals a novel function of GCM1 and HtrA4 in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia
Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice.
Adamson et al., Ottawa, Canada. In Hypertension, 2012
results support a role for reduced placental Gcm1 expression as a causative factor in defective syncytiotrophoblast differentiation and maternal and placental phenotypes in preeclampsia in humans.
PMA induces GCMa phosphorylation and alters its stability via the PKC- and ERK-dependent pathway.
Ueda et al., Gifu, Japan. In Biochem Biophys Res Commun, 2012
these data demonstrate for the first time that GCMa is phosphorylated by the PKC- and MEK/extracellular signal-regulated kinase (ERK)-dependent mechanism, and that this phosphorylation is involved in its degradation process.
Gcm/Glide-dependent conversion into glia depends on neural stem cell age, but not on division, triggering a chromatin signature that is conserved in vertebrate glia.
Giangrande et al., Strasbourg, France. In Development, 2011
Gcm/Glide-dependent conversion into glia depends on neural stem cell age, but not on division, triggering a chromatin signature that is conserved in vertebrate glia
Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.
Akiyama et al., Tokyo, Japan. In Nat Commun, 2010
Data show that beta-catenin/BCL9-Like (BCL9L)/T-cell factor 4 (TCF4) signalling directly targets the GCM1/syncytin pathway and thereby regulates the fusion of human choriocarcinoma cells.
Hydrodynamic glide efficiency in swimming.
Sanders et al., Edinburgh, United Kingdom. In J Sci Med Sport, 2010
The glide is a major part of starts, turns and the stroke cycle in breaststroke.
The evolution, regulation, and function of placenta-specific genes.
Cross et al., Calgary, Canada. In Annu Rev Cell Dev Biol, 2007
A number of placenta-specific genes (e.g., Tpbp, Plac1, Syncytin, and retrotransposon-associated genes such as Peg10, Rtl1, Endothelin B receptor, Insl4, Leptin, Midline1, and Pleiotrophin), enhancer elements (e.g., glycoprotein hormone alpha-subunit) and gene isoforms (e.g., 3betaHSD, Cyp19), as well as placenta-specific members of gene families (e.g., Gcm1, Mash2, Rhox, Esx1, Cathepsin, PAG, TKDP, Psg, Siglec) have been identified.
Branching morphogenesis during development of placental villi.
Watson et al., Calgary, Canada. In Differentiation, 2006
Morphogenesis begins with selection of a subset of trophoblast cells in the basal layer of the chorion that express the Gcm1 transcription factor.
Genetic ablation of parathyroid glands reveals another source of parathyroid hormone.
Karsenty et al., Houston, United States. In Nature, 2000
Glial cells missing2 (Gcm2), a mouse homologue of Drosophila Gcm, is the only transcription factor whose expression is restricted to the parathyroid glands.
The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta.
Cross et al., Toronto, Canada. In Nat Genet, 2000
We show here that Gcm1, encoding the transcription factor glial cells missing-1 (Gcm1), is expressed in small clusters of chorionic trophoblast cells at the flat chorionic plate stage and at sites of chorioallantoic folding and extension when morphogenesis begins.
Glide Mechanisms in Experimentally Deformed Minerals.
Raleigh, In Science, 1965
In specimens strained 5 to 10 percent at 5 to 7 kilobars confining pressure and 700 degrees to 850 degrees C, the glide plane and glide direction for slip and twinning have been determined in olivine, enstatite, kyanite, and diopside.
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