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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Glial fibrillary acidic protein

Glial Fibrillary Acidic Protein, GFAP
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, AGE
Papers using Glial Fibrillary Acidic Protein antibodies
Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury
Joe Eun-hye et al., In Journal of Neuroinflammation, 2010
... Description: Serial slides including adjacent section were stained with the antibodies specific for GFAP (A), S100β (B; 1:800, Swant Bellinzona, Switzerland), GLT-1 (C), ...
Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells.
Chédotal Alain, In PLoS ONE, 2009
... polyclonal antibodies used were: GFP (1∶500, Molecular Probes, A6455), GFAP (1∶500, DAKO, ...
Astrocyte heterogeneity: an underappreciated topic in neurobiology.
Quinlan Roy A., In PLoS ONE, 2009
... Knockout of Nrf2 in Gfap mutant or transgenic mice eliminates ARE (antioxidant ...
Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
Warren Jason D. et al., In Brain, 2009
... p62 (1 : 200, BD Transduction Laboratories), α-synuclein (1 : 50, Vector), Aβ (1 : 100, Dako) and GFAP (1 : 1000, Dako) were used ...
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Papers on Glial Fibrillary Acidic Protein
Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model.
Kaddoumi et al., Monroe, United States. In Biochim Biophys Acta, Feb 2016
In addition, rivastigmine reduced GFAP immunostaining of astrocytes by 50% and IL-1β brain level by 43% in APP(+)/mdr1(+/+) mice, however its effect was less pronounced in P-gp knockout mice.
Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life.
Porciúncula et al., Porto Alegre, Brazil. In Behav Brain Res, Feb 2016
Both caffeine treatment regimens decreased GFAP (as an astrocyte marker) and SNAP-25 (as a nerve terminals marker) in the hippocampus from male rats.
Cognitive Deficits Develop 1 month after Diffuse Brain Injury and are Exaggerated by Microglia-Associated Reactivity to Peripheral Immune Challenge.
Godbout et al., Newcastle, Australia. In Brain Behav Immun, Feb 2016
Examination of mRNA and morphological profiles of glia 30 dpi indicated a low but persistent level of inflammation with elevated expression of GFAP and IL-1β in astrocytes and MHCII and IL-1 β in microglia.
Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS).
Suzuki et al., Madison, United States. In Exp Neurol, Feb 2016
Interestingly, strong expression of activated glial markers, glial fibrillary acidic protein (GFAP) and nestin, was observed in the areas adjacent to NMJs.
Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion.
Maeda et al., Nagasaki, Japan. In Neuroscience, Feb 2016
In addition, systemic post-treatment with P6Q peptide significantly inhibited retinal ischemia-induced microglia and astrocyte activation in terms of increased ionized calcium binding adaptor molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) intensity, respectively, as well as their morphological changes, increased number and migration.
Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy.
Tortella et al., Pittsburgh, United States. In J Neurotrauma, Jan 2016
Incorporation of circulating brain injury biomarker assessments into these pre-clinical studies suggests considerable potential for diagnostic and theranostic utility of glial fibrillary acidic protein (GFAP) in pre-clinical studies.
Microcystic/Reticular Schwannoma of the Mandible First Case Report and Review of the Literature.
Wu et al., Shanghai, China. In Medicine (baltimore), Nov 2015
Tumor cells were also positive for CD34, CD99, and NSE, but negative for CK, EMA, CK5/6, P63, Calponin, CD10, SMA, Desmin, GFAP, NF, Syn, and CgA.
Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells.
Li et al., Shanghai, China. In Cell, Jun 2015
Through single-cell transcriptome and weighted gene co-expression network analysis (WGCNA), we uncovered molecular properties of CD133(+)/GFAP(-) ependymal (E) cells in the adult mouse forebrain neurogenic zone.
Pediatric glioblastoma with giant cells and "supratentorial" primitive neuroectodermal component - case report and review of the literature.
Şovrea et al., Cluj-Napoca / Kolozsvár, Romania. In Rom J Morphol Embryol, 2014
INTRODUCTION: The glial differentiation in pediatric "supratentorial primitive neuroectodermal tumors" (sPNET) is occasionally revealed by immunohistochemistry with GFAP (glial fibrillary acidic protein) as isolated positive cells among undifferentiated cells, indicative of divergent cellular phenotypes.
Astrocytic estrogen receptors and impaired neurotrophic responses in a rat model of perimenopause.
Finch et al., Los Angeles, United States. In Front Aging Neurosci, 2014
In mixed glial cultures from these same cycling subgroups, the E2-dependent neurotrophic activity and glial fibrillary acidic protein (GFAP) repression by E2 were impaired in IR to the same degree as in CE-derived glia.
Biomarkers of Brain Damage and Postoperative Cognitive Disorders in Orthopedic Patients: An Update.
Tomaszewski, Warsaw, Poland. In Biomed Res Int, 2014
In this review the short description of such biomarkers of brain damage as the S100B protein, NSE, GFAP, Tau protein, metalloproteinases, ubiquitin C terminal hydrolase, microtubule-associated protein, myelin basic protein, α-II spectrin breakdown products, and microRNA was made.
Splice site, frameshift, and chimeric GFAP mutations in Alexander disease.
Brenner et al., Birmingham, United States. In Hum Mutat, 2012
The findings recommend inclusion of intronic splice site regions in genetic testing for AxD, indicate that alteration of only a small fraction of GFAP can produce disease, and provide caution against tagging intermediate filaments for investigations.
A histopathological diagnostic marker for human spinal astrocytoma: expression of glial fibrillary acidic protein-δ.
Kang et al., Ch'unch'ŏn, South Korea. In J Neurooncol, 2012
GFAP-delta immunoreactivity was significantly correlated with spinal cord astrocytoma grade in astrocytomas compared to that in normal control tissues.
Temporal progression of kainic acid induced changes in vascular laminin expression in rat brain with neuronal and glial correlates.
Schmued et al., United States. In Curr Neurovasc Res, 2012
In the hippocampus, thalamus, and piriform cortex both vascular laminin and astrocytic GFAP expression are upregulated following kainic acid injection.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Distinct expression/function of potassium and chloride channels contributes to the diverse volume regulation in cortical astrocytes of GFAP/EGFP mice.
Anderova et al., Praha, Czech Republic. In Plos One, 2011
The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1), K(2P) channels (TREK-1 and TWIK-1) and Cl- channels (ClC2).
Specification of transplantable astroglial subtypes from human pluripotent stem cells.
Zhang et al., Madison, United States. In Nat Biotechnol, 2011
In this study, hPSCs were directed to nearly uniform populations of immature astrocytes (>90% S100β(+) and GFAP(+)) in large quantities.
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells.
Götz et al., München, Germany. In Cell Stem Cell, 2011
Sorting of cells from the adult mouse subependymal zone (SEZ) based on their expression of GFAP and prominin1 isolates all self-renewing, multipotent stem cells at high purity.
Central control of fever and female body temperature by RANKL/RANK.
Penninger et al., Vienna, Austria. In Nature, 2009
Using tissue-specific Nestin-Cre and GFAP-Cre rank(floxed) deleter mice, the function of RANK in the fever response was genetically mapped to astrocytes.
High levels of Id1 expression define B1 type adult neural stem cells.
Benezra et al., New York City, United States. In Cell Stem Cell, 2009
We find that high expression of Id1, a dominant-negative helix-loop-helix transcriptional regulator, identifies a rare population of GFAP(+) astrocytes with stem cell attributes among the subventricular astrocytes in the adult brain.
More papers using Glial Fibrillary Acidic Protein antibodies
Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes
Lassmann Hans et al., In Brain, 2009
... Glial fibrillary acidic protein (intermediate filament of mature astrocytes)Dako, Z0334 Lot 096 ...
Protective effects of Natrii sulfas on cerebral focal ischemia induced by MCAO in rats
Mao Lei et al., In Mediators of Inflammation, 2008
... After shaking, the resulting cultures were mainly astrocytes, which were determined by immunoreactivity for GFAP (sc-166481, Santa Cruz Biotechnology, CA, USA) ...
Cell death
Shintaku Masayuki, In Virchows Archiv, 2008
... GCTs of the neurohypophysis were also examined for the expression of glial fibrillary acidic protein (GFAP, polyclonal; Dako; 1:100) ...
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease.
Ikezu Tsuneya, In PLoS ONE, 2007
... Antibodies for immunocytochemistry were mouse anti-MAP2 (sigma) 1/2000, mouse anti-PSD95 (ABR) 1/500, mouse anti-GFAP (clone GA5, Cell Signaling) 1/1000, mouse anti-MPO (Abcam ...
Is COMT a susceptibility gene for schizophrenia?
Seidenbecher Constanze I. et al., In Frontiers in Psychiatry, 2006
... Mouse monoclonal antibodies against microtubule-associated protein 2 (MAP2; 1:1,000) and glial fibrillary acidic protein (GFAP; 1:500) were also obtained from Abcam (ab28032, ab10062).The anti-Thy1.1 mouse ...
The effect of bovine serum albumin on the membrane potential and reactive oxygen species generation in succinate-supported isolated brain mitochondria.
Combs Colin, In PLoS ONE, 2006
... Primary antibody to GFAP was from Dako (rabbit, Carpenteria, CA), to ...
Distinct regulation of MHC molecule expression on astrocytes and microglia during viral encephalomyelitis
Klein Robyn, In PLoS ONE, 2006
... GFAP/IFN-γR1ΔIC (GFAPγR1Δ) transgenic mice ...
In vivo imaging of juxtaglomerular neuron turnover in the mouse olfactory bulb.
Chédotal Alain, In PLoS ONE, 2005
... Rabbit anti-GFAP antibody (ab7260, 1∶200 dilution) was from Abcam.
Neurotrophin-regulated signalling pathways
Tanonaka K et al., In Translational Psychiatry, 2005
... antibodies were used: mouse monoclonal anti-MAP2 (Sigma-Aldrich), detecting neurons; rabbit polyclonal anti-glial fibrillary acidic protein (GFAP) (DAKO, Carpinteria, CA, USA), labeling ...
Quantification of mRNA using real-time RT-PCR.
van der Brug Marcel, In PLoS ONE, 2005
... labeling with neuronal (Milli-Mark™ Pan Neuronal Marker, Millipore MAB2300., Millipore Corp., California, USA) and glial (GFAP, Invitrogen AB5804, Invitrogen Inc., New York, USA) markers, using Leica Application Suite Image Overlay ...
TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7
Simons Mikael et al., In The Journal of Cell Biology, 2004
... Echard, Institut Curie, Paris, France), rabbit anti-GFAP (Promega), mouse antisynaptophysin (Synaptic Systems), rabbit anti-GFP (Abcam; Invitrogen), ...
Comprehensive algorithm for quantitative real-time polymerase chain reaction.
Homayouni Ramin, In PLoS ONE, 2004
... L-thyroxine, selenium selenate, bovine insulin, bovine aprotinin, albumin from bovine serum (BSA), poly-L-lysine (pLL), and anti-GFAP antibody were acquired from Sigma Aldrich (St ...
At the crossroads of inflammation and cancer
Montine Kathleen S et al., In Journal of Neuroinflammation, 2003
... polyclonal anti-human apoE antibody from Dako Corporation (Carpinteria, CA) and polyclonal anti-glial fibrillary astrocytic protein (GFAP) antibody from Novus Biologicals (Littleton, CO) ...
Clades of Adeno-associated viruses are widely disseminated in human tissues
Kaspar Brian K et al., In Molecular Therapy, 2003
... primary antibodies were used in this study: Rabbit-anti-GFP (1:500; Invitrogen), goat-anti-ChAT (1:100; Millipore, Billerica, MA), guinea-pig-anti-GFAP (1:1,000; Advanced Immunochemical, Long Beach, CA) and ...
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron
Klinge Petra M et al., In Cerebrospinal Fluid Research, 2002
... processed for histological assessment using Antibodies against Aβ40/42 (polyclonal; US BIOLOGICAL), glial fibrillary acidic protein (GFAP polyclonal, DAKO) and the microglial marker ...
Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice
Li Xiao-Jiang et al., In The Journal of Cell Biology, 2002
... β5i (LMP7) (BIOMOL International, L.P.); γ-tubulin and synaptophysin (Sigma-Aldrich); GAPDH, neuronal-specific nuclear protein (NeuN), and GFAP (Chemicon International); TFIIB (Santa Cruz Biotechnology, Inc.); SNAP25 (Transduction Laboratories), ...
Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia*
Brown Guy C. et al., In The Journal of Biological Chemistry, 2002
... NeuN antibody was from Chemicon, glial fibrillary acidic protein (GFAP) antibody was from Dako, β-tubulin III antibody was ...
Sustained exposure to bacterial antigen induces interferon-gamma-dependent T cell receptor zeta down-regulation and impaired T cell function.
Aboody Karen S., In PLoS ONE, 2002
... (1∶20, Chemicon), rabbit IgG anti-MAP2 (1∶200, Chemicon), mouse IgG anti-β tubulin III (1∶2000, Sigma), rabbit anti-GFAP (1∶100, Dako), rabbit IgG anti-olig1 (1∶20, ...
Mitochondrial permeability transition can be directly monitored in living neurons
Ghorpade A et al., In Cell Death & Disease, 2001
... to neuronal marker, MAP-2 (Millipore, Billerica, MA, USA) and astrocyte marker, glial fibrillary acidic protein (GFAP, Dako North America, Inc., Carpinteria, ...
Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease
Friedlander Martin et al., In The Journal of Cell Biology, 2000
... GFAP-Cre mice in astrocytes, we mated them with ROSA26 (reverse orientation splice acceptor 26) mTomato/mGFP transgenic reporter mice ( ...
The β-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis
De Keyser Jacques et al., In International Journal of Medical Sciences, 2000
... For immunohistochemistry, primary antibodies used were rabbit anti-GFAP (Sigma; St Louis, MO, USA) and mouse anti-S-100β (Swant, Bellinzona, Switzerland) ...
Dystroglycan distribution in adult mouse brain: a light and electron microscopy study
van der Knaap Marjo S. et al., In Acta Neuropathologica, 2000
... ]); glial fibrillary acidic protein (GFAP, polyclonal; 1:500, DAKO, Heverlee, Belgium) and NeuN ...
Lysosmal Storage Diseases
Taniike Masako et al., In Journal of Neuroinflammation, 2000
... of glutathione-S-transferase (pi-GST) antibody (1:1000; MBL, Nagoya, Japan), rabbit polyclonal anti-cow glial fibrillary acidic protein (GFAP) antibody (prediluted; DAKO, Glostrup, Denmark), biotinylated ...
Inhibitor of neurite outgrowth in humans.
Cookson Mark R., In PLoS ONE, 1999
... Nogo-R (Catalog #: sc-25659, Santa Cruz Biotechnology); GFAP (Catalog #: ab929, ABCAM); NeuN and β III ...
A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals
Nguyen Trung P. et al., In Journal of Neuroimmune Pharmacology, 1998
... GFAP (2E1)BD Biosciences ...
Transplanted embryonic entorhinal neurons make functional synapses in adult host hippocampus
Navarro-López Juan D. et al., In Frontiers in Neurology, 1997
... A polyclonal rabbit anti-GFAP antibody (Dako; 1:1000) was used to ...
BDNF attenuates functional and structural disorders in nerves of galactose-fed rats.
Singh Shree Ram, In PLoS ONE, 1996
... #AF980; 0.1 µg/ml), rabbit anti-GFAP (Dako, Carpinteria, CA, cat ...
Live astrocytes visualized by green fluorescent protein in transgenic mice
Bordey Angélique et al., In Frontiers in Neuroscience, 1996
... GFAP promoter drives Muller cell-specific expression in transgenic mice ...
Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.
Gendelman Howard E., In PLoS ONE, 1995
... were used: anti-O4 (1∶20, Chemicon), anti-Tuj1 (1∶500, Covance), anti-Nestin (1∶50, Rat 401 DSHB-University of Iowa), anti-GFAP (1∶1000, DAKO), anti-HSP90 (1∶1000, Cell Signaling), ...
In vivo phosphorylation of regulatory light chain of myosin II during mitosis of cultured cells
Inagaki Masaki et al., In The Journal of Cell Biology, 1993
... For expression of wild-type GFAP, cDNA for human GFAP (Reeves et al., 1989) was introduced in the expression vector pDR2 (Clontech ...
Autolytic transition of mu-calpain upon activation as resolved by antibodies distinguishing between the pre- and post-autolysis forms.
Okazawa Hitoshi, In PLoS ONE, 1991
... as follows: mouse anti-Nestin (1∶200, Millipore, Temecula, CA), mouse anti-Tuj1 (1∶2000, Covance, Princeton, NJ), rabbit anti-GFAP (1∶500, DAKO, Carpinteria, CA), rabbit anti-Synapsin ...
Neuronal ubiquitin and neurofilament expression in different lysosomal storage disorders
Elleder Milan et al., In Acta Neuropathologica, 1991
... Glial fibrillary acidic protein - GFAP (6F2) DAKO, Copenhagen, Denmark ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
Aboody Karen S., In PLoS ONE, 1991
... ebioscience, primary antibodies for immunofluorescence and immunohistochemistry (CD45, F4/80, CD205, CD4, CD8, CD19, CD25 and GFAP) were all purchased from Serotec and biotinylated secondary antibodies were purchased from Dako (Denmark) and fluorescent tagged ...
A case of Alzheimer’s disease and hippocampal sclerosis with normal cholinergic activity in basal forebrain, neocortex, and hippocampus
Dickson Dennis W. et al., In Acta Neuropathologica, 1988
... The following primary antibodies were used: anti-GFAP (GA-5, monoclonal, 1:1,000, Biogenex, San Ramon, CA), anti-HLA-DR ...
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
Sánchez-Capelo Amelia et al., In Molecular Neurodegeneration, 1979
... Boy, France), rat anti-DAT (1:500, Chemicon), rabbit anti-GFAP (1:2750, Abcam), and mouse anti-α-synuclein antibodies ...
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