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GLI family zinc finger 3

This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Gli, Shh
Papers using Gli3 antibodies
Getting more from less: algorithms for rapid protein identification with multiple short peptide sequences
Grzeschik Karl-Heinz et al., In BMC Developmental Biology, 2001
... GLI3 Selected for Functional Analysis in Transgenic mice assay.
Papers on Gli3
Nutritional approaches to ameliorate pulmonary hypertension in broiler chickens.
Wideman et al., Sārī, Iran. In J Anim Physiol Anim Nutr (berl), Feb 2016
This article reviews recent nutritional approaches for counteracting the development of pulmonary hypertension syndrome (PHS; ascites) in broiler chickens especially when they are reared at high altitudes.
Binding small molecules and ions to [Fe4S4Cl4](2-) modulates rate of protonation of the cluster.
Henderson et al., Karbalā', Iraq. In Dalton Trans, Feb 2016
The mechanism of the acid-catalyzed substitution reaction of the terminal chloro-ligands in [Fe4S4Cl4](2-) by PhS(-) in the presence of NHBu(n)3(+) involves rate-limiting proton transfer from NHBu(n)3(+) to the cluster (k0 = 490 ± 20 dm(3) mol(-1) s(-1)).
Glioma-associated oncogene-2 is essential for trophoblastic fusion by forming a transcriptional complex with Glial cell missing-a.
Wu et al., Tokyo, Japan. In J Biol Chem, Feb 2016
Moreover, among Glioma-associated oncogene (GLI) family transcriptional factors in Hedgehog signaling, knockdown of GLI2 but not GLI1 and GLI3 significantly attenuated Hedgehog-induced cell fusion, whereas overexpression of GLI2 activator alone was sufficient to induce cell fusion.
MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3.
He et al., Shanghai, China. In Oncotarget, Feb 2016
Moreover, we demonstrated that GLI3 was a direct target of miR-133b and the expression of Cyclin B1 and Cyclin D1 was enhanced by miR-133b mimics but decreased by its inhibitors.
The early history of Pallister-Hall syndrome-Buried treasure of a sort.
Hall, Canada. In Gene, Feb 2016
Shortly after familial cases were recognized, the responsible gene was identified at GLI3.
Identification of markers linked to genes for sprouting tolerance (independent of grain color) in hard white winter wheat (HWWW).
Baenziger et al., Lincoln, United States. In Theor Appl Genet, Jan 2016
Pre-harvest sprouting (PHS) of wheat (Triticum aestivum L.) can negatively impact end-use quality and seed viability at planting.
PLANT VOLATILES. Biosynthesis of monoterpene scent compounds in roses.
Baudino et al., Saint-Étienne, France. In Science, Aug 2015
Monoterpenes represent up to 70% percent of the scent content in some cultivars, such as the Papa Meilland rose.
[Diagnosis and Clinical Examination of Autoinflammatory Syndrome].
Ida, In Rinsho Byori, May 2015
The main monogenic autoinflammatory syndromes are familial Mediterranean fever (FMF), TNF receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD), cryopyrin-associated periodic syndrome (CAPS), Blau syndrome, and pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome.
Dinitrosyl iron complexes (DNICs): from biomimetic synthesis and spectroscopic characterization toward unveiling the biological and catalytic roles of DNICs.
Liaw et al., Taiwan. In Acc Chem Res, May 2015
In addition, Fe/S K-edge X-ray absorption spectroscopy of tetrahedral DNICs deduced the qualitative assignment of Fe/NO oxidation states of {Fe(NO)2}(9) DNICs as a resonance hybrid of {Fe(II)((•)NO)(NO(-))}(9) and {Fe(III)(NO(-))2}(9) electronic states; the quantitative NO oxidation states of [(PhS)3Fe(NO)](-), [(PhS)2Fe(NO)2](-), and [(PhO)2Fe(NO)2](-) were further achieved by newly developed valence to core Fe Kβ X-ray emission spectroscopy as -0.58 ± 0.18, -0.77 ± 0.18, and -0.95 ± 0.18, respectively.
A common immunopathogenesis mechanism for infectious diseases: the protein-homeostasis-system hypothesis.
Lee, Seoul, South Korea. In Infect Chemother, Mar 2015
The author proposes that this network is controlled by the protein homeostasis system (PHS), and that the immune system is one part of the PHS of the host.
Advances in the molecular genetics of non-syndromic polydactyly.
Yuan et al., Changsha, China. In Expert Rev Mol Med, 2014
To date, in human, at least ten loci and four disease-causing genes, including the GLI3 gene, the ZNF141 gene, the MIPOL1 gene and the PITX1 gene, have been identified.
Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance.
Athar et al., Mobile, United States. In Cancers (basel), 2014
The canonical hedgehog (HH) pathway is a multicomponent signaling cascade (HH, protein patched homolog 1 (PTCH1), smoothened (SMO)) that plays a pivotal role during embryonic development through activation of downstream effector molecules, namely glioma-associated oncogene homolog 1 (GLI1), GLI2 and GLI3.
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
Leung et al., San Diego, United States. In Nat Genet, 2014
We identified previously known (TP53, ARID1A and CDH1) and new (MUC6, CTNNA2, GLI3, RNF43 and others) significantly mutated driver genes.
Mutant PTEN in Cancer: Worse Than Nothing.
den Hertog et al., Utrecht, Netherlands. In Cell, 2014
Papa et al.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Joyner et al., New York City, United States. In Dev Biol, 2012
Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors.
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
Fernandez-Zapico et al., Rochester, United States. In J Biol Chem, 2012
AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2).
Rice et al., Helsinki, Finland. In J Biol Chem, 2012
a novel role for Gli3 in regulating calvarial suture development by controlling canonical Bmp-Smad signaling, which integrates a Dlx5/Runx2-II cascade
[Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus].
Jin et al., Shenyang, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
No expression of GLI3 gene was detected in the flexor hallucis longus of ICTEV patients or normal controls.
KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes.
Attié-Bitach et al., Paris, France. In Nat Genet, 2011
Consistent with a role of KIF7 in Hedgehog signaling, we show deregulation of most GLI transcription factor targets and impaired GLI3 processing in tissues from individuals with KIF7 mutations.
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