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Galactokinase 2

GK2, N-acetylgalactosamine kinase, GalNAc kinase, GALK2
This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: galactokinase, NGF, CAN, HAD, fibrillin-1
Papers on GK2
Silica Measurement with High Flow Rate Respirable Size Selective Samplers: A Field Study.
O'Brien et al., Morgantown, United States. In Ann Occup Hyg, Dec 2015
UNASSIGNED: High and low flow rate respirable size selective samplers including the CIP10-R (10 l min(-1)), FSP10 (11.2 l min(-1)), GK2.69 (4.4 l min(-1)), 10-mm nylon (1.7 l min(-1)), and Higgins-Dewell type (2.2 l min(-1)) were compared via side-by-side sampling in workplaces for respirable crystalline silica measurement.
Identification of a panel of complex autoantigens (LGALS3, PHB2, MUC1, and GK2) in combination with CA15-3 for the diagnosis of early-stage breast cancer.
Qin et al., Xi'an, China. In Tumour Biol, Sep 2015
In the end, a panel of complex autoantigens consisting of B11 (LGALS3), B18 (PHB2), B119 (MUC1), B130 (GK2), and CA15-3, which had a sensitivity of 87 % and a specificity of 76 %, were identified.
An Optimal Medium Supplementation Regimen for Initiation of Hepatocyte Differentiation in Human Induced Pluripotent Stem Cells.
Ishige et al., Yotsukaidō, Japan. In J Cell Biochem, Aug 2015
The expression of GALK2, OTC, and CYP3A4 were increased.
Effectiveness of GK-2, a Nerve Growth Factor Mimetic, in Preventing Post-Resuscitation Changes in the Brain.
Seredenin et al., Moscow, Russia. In Bull Exp Biol Med, Aug 2015
Intraperitoneal administration of GK-2 (1 mg/kg 30 min after resuscitation and within the next 3 days with an interval of 24 h) accelerated neurological recovery of the animals, sharply reduced the intensity of cerebellar Purkinje cell death, and prevented loss of pyramidal neurons in the hippocampus.
Behavioral effect of dipeptide NGF mimetic GK-2 in an in vivo model of rat traumatic brain injury and its neuroprotective and regenerative properties in vitro.
Isaev et al., Moscow, Russia. In Int J Neurosci, May 2015
A protective behavioral effect of a nerve growth factor dipeptide mimetic GK-2 in the model of open focal trauma of rat brain sensorimotor cortex and its antioxidative and regenerative properties in cultures of rat cerebellar granule cells and mouse embryonal spinal ganglion, respectively, were studied.
[Effect of the nerve growth factor mimetic GK-2 on post-resuscitation expression of neurotrophic factors].
Seredenin et al., In Patol Fiziol Eksp Ter, Apr 2015
THE OBJECTIVE: to elucidate an influence of nerve growth factor mimetic GK-2 on the expression of neurotrophic factors and the process of neuronal death after ischemia-reperfusion. Materials and methods.
The effect of sarafloxacin on Cu/ZnSOD structure and activity.
Chen et al., Jinan, China. In Spectrochim Acta A Mol Biomol Spectrosc, Mar 2015
The binding area locates on the surface of β-barrel close to the second Greek key loop (GK2) and V-loop but far away from the active site and active site channel of Cu/ZnSOD.
An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma.
Livingston et al., Boston, United States. In Proc Natl Acad Sci U S A, Feb 2015
We identified genes previously implicated in ovarian cancer such as AURKA1, ERBB3, CDK2, and mTOR, as well as several novel candidates including BRD4, VRK1, and GALK2.
Anti-inflammatory effects of adenosine N1-oxide.
Fukuda et al., Okayama, Japan. In J Inflamm (lond), 2014
METHODS: The effect of ANO on pro-inflammatory cytokine secretion was examined in mouse peritoneal macrophages and the human monocytic cell line THP-1, and compared with that of adenosine, synthetic adenosine receptor (AR)-selective agonists and dipotassium glycyrrhizate (GK2).
Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.
Seredenin et al., Moscow, Russia. In J Biomed Sci, 2014
Two dimeric dipeptides, bis-(N-aminocaproyl-glycyl-L-lysine) hexamethylenediamide (GK-6) and bis(N-succinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2), were designed based on the most exposed outside fragments of NGF, namely, the loop 1 and loop 4 β-turn sequences, respectively.
Collection efficiencies of high flow rate personal respirable samplers when measuring Arizona road dust and analysis of quartz by x-ray diffraction.
Harper et al., Buxton, United Kingdom. In Ann Occup Hyg, 2014
The performance of FSP10, GK2.69, and CIP 10 R samplers were compared with that of the Safety In Mines Personal Dust Sampler (SIMPEDS) sampler as a reference, which is commonly used in the UK for the measurement of RCS.
A whole genomic scan to detect selection signatures between Berkshire and Korean native pig breeds.
Kim et al., Ch'ŏngju, South Korea. In J Anim Sci Technol, 2013
Results revealed that 19 candidate genes were enriched in phosphate metabolism (GO: 0006796; ADCK1, ACYP1, CAMK2D, CDK13, CDK13, ERN1, GALK2, INPP1; MAK, MAP2K5, MAP3K1, MAPK14, P14KB, PIK3C3, PRKC1, PTPRK, RNASEL, THBS1, BRAF, VRK1).
Quartz in coal dust deposited on internal surface of respirable size selective samplers.
Harper et al., Morgantown, United States. In J Occup Environ Hyg, 2013
Coal dust was collected with four different respirable size-selective samplers (10 mm Dorr-Oliver nylon [Sensidyne, St. Petersburg, Fla.], SKC Aluminum [SKC Inc., Eighty Four, Pa.], BGI4L [BGI USA Inc., Waltham, Mass.], and GK2.69 cyclones [BGI USA Inc.]) with two different cassette types (polystyrene and static-dissipative polypropylene cassettes).
[Studying in vitro neuroprotective properties of GK-2(h)--a new original mimetic of human nerve growth factor].
Seredenin et al., In Eksp Klin Farmakol, 2013
Human nerve growth factor (NGF) mimetic hexamethylenediamide bis-N-monosuccinyl-glicyl-lysine) (GK-2(h)) demonstrates protective activity on immortalized mouse hippocampal cell line HT22 in a concentration up to 10(-13)M against hydrogen peroxide toxicity and in concentration up to 10(-8) M against glutamate toxicity.
[Hypocoagulant effect of the novel dipeptide NGF mimetic GK-2].
Seredenin et al., In Eksp Klin Farmakol, 2012
The effect of an original dimeric dipeptide NGF mimetic, GK-2 (hexamethylenediamide bis-N-monosuccinyl-L-glutamyl-L-lysine, designed on the basis of the beta-turn of the 4th NGF loop) on the hemostasis and fibrinolysis was studied in intact and diabetic Wistar rats in various periods of disorder development.
Mechanistic studies on human N-acetylgalactosamine kinase.
Timson et al., Belfast, United Kingdom. In J Enzyme Inhib Med Chem, 2010
Kinetic studies suggest an ordered ternary complex mechanism in which ATP is the first substrate to bind.
The molecular architecture of human N-acetylgalactosamine kinase.
Holden et al., Madison, United States. In J Biol Chem, 2005
geometry and substrate specificity of the GalNAc kinase active site before and after catalysis
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