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Potassium inwardly-rectifying channel, subfamily J, member 3

GIRK1, Kir3.1, KGA
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GIRK2, C1r, CAN, ACID, Kir2.1
Papers on GIRK1
Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells.
Logothetis et al., Richmond, United States. In Pflugers Arch, Feb 2016
To investigate whether mGlu2R and 2AR can cross-signal in mammalian cells, we stably co-expressed them in HEK293 cells along with the GIRK1/GIRK4 channel, a reporter of Gi and Gq signaling activity.
Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells.
Gribble et al., Cambridge, United Kingdom. In Br J Pharmacol, Jan 2016
KEY RESULTS: Galanin receptor 1 (Galr1) and GIRK channel 1 (Kir 3.1, Kcnj3) and 4 (Kir 3.4, Kcnj5) mRNA expression was highly enriched in K and L cells.
Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.
Zacharewski et al., Toronto, Canada. In Toxicol Sci, Dec 2015
In addition, the GAC:KGA glutaminase (GLS1) protein isoform ratio was increased, consistent with increases in glutaminolysis which serves an anaplerotic role for the TCA cycle and compensates for the reduced glycolytic flux.
Glutaminases in slowly proliferating gastroenteropancreatic neuroendocrine neoplasms/tumors (GEP-NETs): Selective overexpression of mRNA coding for the KGA isoform.
Albrecht et al., Warsaw, Poland. In Exp Mol Pathol, Dec 2015
Human glutaminases are encoded by two genes: the GLS gene encodes the kidney-type glutaminases, KGA and GAC, while the GLS2 gene encodes the liver-type glutaminases, GAB and LGA.
A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.
Dascal et al., Tel Aviv-Yafo, Israel. In Plos Comput Biol, Nov 2015
We have previously shown for heterologously expressed neuronal GIRK1/2, and now show for native GIRK in hippocampal neurons, that Ibasal and Ievoked are interrelated: the extent of activation by neurotransmitter (activation index, Ra) is inversely related to Ibasal.
Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.
Albrecht et al., Warsaw, Poland. In Neurochem Int, Sep 2015
Human GA isoforms are encoded by two genes: GLS gene codes for kidney-type isoforms, KGA and GAC, whereas GLS2 codes for liver-type isoforms, GAB and LGA.
Localization and Targeting of GIRK Channels in Mammalian Central Neurons.
Aguado et al., Albacete, Spain. In Int Rev Neurobiol, 2014
Molecular cloning has revealed four distinct mammalian genes (GIRK1-4), which, with the exception of GIRK4, are broadly expressed in the central nervous system (CNS) and have been implicated in a variety of neurological disorders.
Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment.
Siegelbaum et al., New York City, United States. In Cell, 2014
We find that Reelin signaling is required for the striking enrichment of HCN1 and GIRK1 channels in the distal tuft dendrites of both hippocampal CA1 and neocortical layer 5 pyramidal neurons, where the channels actively filter inputs targeted to these dendritic domains.
Focus on Kir7.1: physiology and channelopathy.
Pattnaik et al., India. In Channels (austin), 2013
Native human RPE expresses transcripts for Kir1.1, Kir2.1, Kir2.2, Kir3.1, Kir3.4,
Atrial selectivity of antiarrhythmic drugs.
Knaut et al., Dresden, Germany. In J Physiol, 2013
Currently recognized atrial selective targets include atrial Nav1.5 channels, Kv1.5 channels and constitutively active Kir3.1/3.4 channels, each of which confers atrial selectivity by different mechanisms.
Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism.
Chavkin et al., Seattle, United States. In J Neurosci, 2012
Mechanism for functional dysregulation in the dorsal raphe follows tyrosine phosphorylation of repeated stress-activated Kir3.1 channels.
Discovery and Characterization of a Selective Activator of the G-Protein Activated Inward-Rectifying Potassium (GIRK) Channel
Weaver et al., Bethesda, United States. In Unknown Journal, 2012
ML297 shows a preference for the GIRK1/GIRK2 subunit combination compared to GIRK1/GIRK4 and is inactive on GIRK2/GIRK3 and a number of other potassium channels.
Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population.
Yoshikawa et al., Wako, Japan. In Hum Genet, 2012
These data suggest that the KCNJ3 gene is genetically associated with schizophrenia in Asian populations and add further evidence to the "channelopathy theory of psychiatric illnesses".
Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium.
MacKinnon et al., New York City, United States. In Cell, 2011
G protein-gated K(+) channels (Kir3.1-Kir3.4)
Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits.
Dascal et al., Tel Aviv-Yafo, Israel. In J Biol Chem, 2011
The mechanisms of regulation of GIRK by Galpha(i/o) using wild-type Galpha(i3) (Galpha(i3)WT) and Galpha(i3), were investigated.
Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle.
Gregerson et al., Cincinnati, United States. In Am J Physiol Regul Integr Comp Physiol, 2011
Estradiol regulates dopamine-activataed GIRK channel activity in pituitary lactotrophs, regulating prolactin release during the estrous cycle.
Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27.
Slesinger et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2011
The surface expression of neuronal GIRK channels is regulated by the psychostimulant-sensitive sorting nexin 27 (SNX27) protein through a class I PDZ-binding interaction.
Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution.
MacKinnon et al., New York City, United States. In Cell, 2003
A cytoplasmic pore in the GIRK1 channel extends the ion pathway to 60 A, nearly twice the length of a canonical transmembrane K(+) channel. The cytoplasmic pore is lined by acidic and hydrophobic amino acids; polyamines block this pore.
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma.
Hilgemann et al., Dallas, United States. In Nature, 1998
Stabilized by lipid phosphatase inhibitors, PIP2 antibodies potently inhibit each channel with a unique rate (GIRK1/4 approximately GIRK2 >> IRK1 approximately ROMK.
RGS8 accelerates G-protein-mediated modulation of K+ currents.
Nakata et al., Tokyo, Japan. In Nature, 1998
When co-expressed in Xenopus oocytes with a G-protein-coupled receptor and a G-protein-coupled inwardly rectifying K+ channel (GIRK1/2), RGS8 accelerated not only the turning off but also the turning on of the GIRK1/2 current upon receptor stimulation, without affecting the dose-response relationship.
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