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Gastric inhibitory polypeptide receptor

GIPR, glucose-dependent insulinotropic polypeptide receptor, gastric inhibitory polypeptide receptor
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: GIP, Insulin, Glucagon, E4, fibrillin-1
Papers on GIPR
A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat.
Li et al., Taiyuan, China. In Neuroreport, Feb 2016
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists have been shown to be neuroprotective in previous studies in animal models of Alzheimer's or Parkinson's disease.
TCF1 links GIPR signaling to the control of beta cell function and survival.
Drucker et al., Toronto, Canada. In Nat Med, Jan 2016
Although the GLP-1 receptor (GLP-1R) is a validated drug target for diabetes, the importance of the GIP receptor (GIPR) for the function of beta cells remains uncertain.
Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
Gomez et al., Malmö, Sweden. In Diabetes, Jan 2016
GIP receptor (GIPR) and OPN mRNA levels are higher in carotid endarterectomies from patients with symptoms (stroke, transient ischemic attacks, amaurosis fugax) than in asymptomatic patients, and expression associates with parameters that are characteristic of unstable and inflammatory plaques (increased lipid accumulation, macrophage infiltration, and reduced smooth muscle cell content).
Temporal and Regional Expression of Glucose-Dependent Insulinotropic Peptide and Its Receptor in Spinal Cord Injured Rats.
Figueiredo et al., Florianópolis, Brazil. In J Neurotrauma, Jan 2016
It is known that glucose-dependent insulinotropic peptide (GIP) and its receptor (GIPR) can enhance synaptic plasticity, neurogenesis, and axonal outgrowth.
A High Fat Diet during Mouse Pregnancy and Lactation targets GIP-regulated Metabolic Pathways in Adult Male Offspring.
Pfeiffer et al., Germany. In Diabetes, Jan 2016
Genetic deletion of the Gastric Inhibitory Polypeptide Receptor (GIPR) prevents high fat diet induced obesity in mice due to specific changes in energy and fat cell metabolism.
A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.
Gribble et al., Cambridge, United Kingdom. In Endocrinology, Nov 2015
Pyy, Gipr, Chrm4, Calcrl, Taar1, and Casr were identified as genes that are highly enriched in D-cells compared with SST-negative cells.
Internalization and desensitization of the human glucose-dependent-insulinotropic receptor is affected by N-terminal acetylation of the agonist.
Fourmy et al., Toulouse, France. In Mol Cell Endocrinol, Nov 2015
We have studied internalization of the human Glucose-Insulinotropic Polypeptide receptor (GIPR).
Evolution of receptors for peptides similar to glucagon.
Irwin, Toronto, Canada. In Gen Comp Endocrinol, 2015
A total of five types of genes for receptors for these peptides have been identified, three for the products of GCG (GCGR, GLP1R, and GLP2R) and one each for the products of GIP (GIPR) and the ortholog of exendin (Grlr).
Gastrointestinal neuroendocrine tumors (NETs): new diagnostic and therapeutic challenges.
Oberg et al., Córdoba, Spain. In Cancer Metastasis Rev, 2014
In addition to the classic agents, there are a series of new agents targeting other receptors such as the incretin receptors (GLP-1R; GIPR) and other G-protein coupled receptors with great potential.
Incretin actions beyond the pancreas: lessons from knockout mice.
Seino et al., Ōsaka, Japan. In Curr Opin Pharmacol, 2013
GIP and GLP-1 actions are mediated by specific receptors, the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R), which are expressed in pancreatic β cells and various other tissues and organs.
Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas.
Yabe et al., Ōsaka, Japan. In J Diabetes Investig, 2013
The actions of GIP and GLP-1 are mediated by their specific receptors, the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R), which are expressed in pancreatic β-cells, as well as in various tissues and organs.
Pax6 is a key component of regulated glucagon secretion.
Philippe et al., Genève, Switzerland. In Endocrinology, 2012
Results indicate that Pax6 acts on the regulation of glucagon secretion at least through the transcriptional control of GCK, GPR40, and GIPR.
Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort.
Orho-Melander et al., Malmö, Sweden. In J Clin Endocrinol Metab, 2012
Our prospective, observational study indicates that the type 2 diabetes risk by dietary intake of carbohydrate and fat may be dependent on GIPR genotype.
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
Tanaka et al., Yokohama, Japan. In Nat Genet, 2012
Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass index-associated loci in the CDKAL1 locus at 6p22 (rs2206734, P = 1.4 × 10(-11)) and the KLF9 locus at 9q21 (rs11142387, P = 1.3 × 10(-9)), as well as several previously reported loci (the SEC16B, BDNF, FTO, MC4R and GIPR loci, P < 5.0 × 10(-8)).
Glucose-dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors.
Reubi et al., Bern, Switzerland. In J Clin Endocrinol Metab, 2012
Most of the somatostatin receptor-negative neuroendocrine tumors and GLP-1 receptor-negative malignant insulinomas are GIP receptor positive.
Weight-loss diets modify glucose-dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: the Preventing Overweight Using Novel Dietary Strategies trial.
Qi et al., Boston, United States. In Am J Clin Nutr, 2012
The T allele of GIPR rs2287019 is associated with greater improvement of glucose homeostasis in individuals who choose a low-fat, high-carbohydrate, and high-fiber diet.
Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.
Accili et al., Vancouver, Canada. In Plos One, 2011
Functional expression of a GIP receptor mutant lacking N-glycosylation is rescued by co-expressed wild type GLP1 receptor, which suggests formation of a GIP-GLP1 receptor heteromer.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Loos et al., Cambridge, United States. In Nat Genet, 2010
Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor.
GIP and GLP-1, the two incretin hormones: Similarities and differences.
Yabe et al., Okayama, Japan. In J Diabetes Investig, 2010
GIP and GLP-1 exert their effects by binding to their specific receptors, the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R), which belong to the G-protein coupled receptor family.
Inhibition of gastric inhibitory polypeptide signaling prevents obesity.
Seino et al., Kyoto, Japan. In Nat Med, 2002
In contrast, mice lacking the GIP receptor (Gipr(-/-)) fed a high-fat diet were clearly protected from both the obesity and the insulin resistance.
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