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Ghrelin/obestatin prepropeptide

This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: leptin, Insulin, HAD, fibrillin-1, CAN
Papers using ghrelin antibodies
Interactions between ghrelin, leptin and IGF-I affect metabolic syndrome and early atherosclerosis
Sarrafzadegan Nizal et al., In ARYA Atherosclerosis, 2007
... Ghrelin was measured using ELISA method and BioVendor kits ...
Effects of increased dietary fat and exercise on skeletal muscle lipid peroxidation and antioxidant capacity in male rats.
Lanza Ian, In PLoS ONE, 2004
... in the HF group were randomized to receive eight subcutaneous injections of either acylated rat ghrelin as previously reported [8], [13] (AnaSpec, San Jose, CA) (HFG, ...
Suppression of vagus-mediated pancreatic polypeptide release by the µ-opiate receptor agonist loperamide
Luque Raul M., In PLoS ONE, 1995
... were commercially available kits (Motilin: Euro-Diagnostica, Malmö, Schweden; Gastrin: GASK-PR, Isotopen Diagnostik CIS, Dreieich, Germany; Ghrelin: Phoenix Pharmaceuticals, Belmont, CA, USA) ...
Papers on ghrelin
Comparative Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Glucose Homeostasis and Incretin Hormones in Obese Type 2 Diabetic Patients: A One-Year Prospective Study.
Capaldo et al., Napoli, Italy. In Horm Metab Res, Feb 2016
Both fasting and post-meal ghrelin concentrations were markedly suppressed after VSG and significantly lower than RYGB (p=0.013 to p=0.035).
Gastric ghrelin, GOAT, leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity.
Bischoff et al., Stuttgart, Germany. In Neurogastroenterol Motil, Feb 2016
We studied the expression of ghrelin, leptin, and the serotonergic system in stomach tissue and serum of obese and non-obese individuals.
Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo.
Jackson et al., Cambridge, United States. In Br J Pharmacol, Feb 2016
BACKGROUND AND PURPOSE: Ghrelin increases growth hormone secretion, gastric acid secretion, gastric motility and hunger but decreases glucose-dependent insulin secretion and insulin sensitivity in humans.
Novel Diet, Drugs and Gastric Interventions for Gastroparesis.
Camilleri, Rochester, United States. In Clin Gastroenterol Hepatol, Feb 2016
The novel medications include the motilin agonist, camicinal, 5-HT4 receptor agonists such as velusetrag, and the ghrelin agonist, relamorelin.
Biomarkers in the diagnosis and study of psychogenic nonepileptic seizures: A systematic review.
Jimenez et al., Cleveland, United States. In Seizure, Jan 2016
Other miscellaneous biomarkers (neuron specific enolase, brain derived neurotropic factor, ghrelin, leptin, leukocytosis) showed no conclusive evidence of utility.
Ghrelin and Blood Pressure Regulation.
Kishimoto et al., Akron, United States. In Curr Hypertens Rep, Jan 2016
High expression of growth hormone secretagogue receptor, the ghrelin receptor, in the heart, kidney, and blood vessels provides evidence of ghrelin activity in blood pressure regulation.
Improvement of plasma adiponectin, leptin and c-reactive protein concentrations by orlistat: A systematic review and meta-analysis.
Sahebkar et al., Pavia, Italy. In Br J Clin Pharmacol, Jan 2016
BACKGROUND: To conduct a systematic review and meta-analysis of relevant randomized clinical trials (RCTs) to ascertain the effect size of orlistat in modulating plasma levels of adipokines, ghrelin and C-reactive protein (CRP).
Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: Potential mechanisms.
Copeland et al., Waterloo, Canada. In Appetite, Jan 2016
As the effectiveness of exercise to induce weight loss is a controversial topic, there is considerable interest in the effect of exercise on the appetite-regulating hormones such as acylated ghrelin, peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and pancreatic polypeptide (PP).
Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor.
Smith et al., Jupiter, United States. In Cell, Dec 2015
The ghrelin receptor (GHSR1a) and dopamine receptor-1 (DRD1) are coexpressed in hippocampal neurons, yet ghrelin is undetectable in the hippocampus; therefore, we sought a function for apo-GHSR1a.
Palatability Can Drive Feeding Independent of AgRP Neurons.
Luquet et al., Paris, France. In Cell Metab, Nov 2015
Using models of neuronal inhibition or ablation, we demonstrate that the feeding response to a fast ghrelin or serotonin receptor agonist relies on AgRP neurons.
Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials.
Friend et al., Houston, United States. In Lancet Oncol, 2015
Anamorelin is an oral ghrelin-receptor agonist with appetite-enhancing and anabolic activity.
Polymorphisms in the GHRL gene and their associations with traits of economic interest in beef cattle.
Tonhati et al., Jaboticabal, Brazil. In Genet Mol Res, 2014
Therefore, the ghrelin gene (GHRL) is considered to be a good candidate marker for the identification of traits of great economic importance in cattle, such as those associated with feed intake, growth, and carcass quality.
Prandial States Modify the Reactivity of the Gustatory Cortex Using Gustatory Evoked Potentials in Humans.
Brondel et al., Dijon, France. In Front Neurosci, 2014
Modifications in the primary taste area activity during the post-prandial period occurred regardless of the nature of the food eaten and could represent the activity of the frontal operculum and insula, which was recently shown to be modulated by gut signals (GLP-1, CCK, ghrelin, or insulin) through vagal afferent neurons or metabolic changes of the internal milieu after nutrient absorption.
Novel and conventional receptors for ghrelin, desacyl-ghrelin, and pharmacologically related compounds.
Furness et al., Melbourne, Australia. In Pharmacol Rev, 2014
The only molecularly identified ghrelin receptor is the growth hormone secretagogue receptor GHSR1a.
Starving for ghrelin.
Spanswick et al., Australia. In Cell Metab, 2014
The initial discovery of ghrelin as a potent orexigenic hormone raised excitement about a new direction for possibly treating eating disorders.
Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice.
Sun et al., Houston, United States. In Am J Physiol Endocrinol Metab, 2012
The paradoxical effects of ghrelin ablation and Ghsr ablation in ob/ob mice highlight the complexity of the ghrelin-signaling pathway.
Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells.
Yada et al., Tochigi, Japan. In Febs Lett, 2012
Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet beta-cells
Association between ghrelin levels and BMD: a cross sectional trial.
Hassouna et al., Cairo, Egypt. In Gynecol Endocrinol, 2012
Data suggest a positive association between plasma ghrelin and both bone mineral density (BMD) and plasma estradiol; plasma ghrelin is significantly decreased in perimenopausal and postmenopausal women in comparison to premenopausal women.
Circulating ghrelin levels are not associated with craving and withdrawal symptoms in acute nicotine withdrawal.
Gutzeit et al., In Psychiatr Danub, 2012
ghrelin was no associated with nicotine withdrawal symptoms and tobacco craving in smokers with acute nicotine withdrawal
Ghrelin and growth hormone secretagogue receptor (GHSR) genes are not commonly involved in growth or weight abnormalities in an Israeli pediatric population.
Tenenbaum-Rakover et al., Israel. In J Pediatr Endocrinol Metab, 2011
Despite the major role of ghrelin in growth and appetite regulation, our results indicate that mutations in ghrelin and GHSR do not explain short stature and weight regulation disorders in children in our population.
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