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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein geranylgeranyltransferase type I, beta subunit

GGTI, PGGT1B, GGTase-I beta
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoA, V1a, ACID, HAD
Papers using GGTI antibodies
Defects of cholesterol biosynthesis
Waterham H. R. et al., In Journal of Inherited Metabolic Disease, 2005
... the medium was replaced with fresh culture medium supplemented with either 20 μM geranylgeranyltransferase inhibitor (GGTI-298; Calbiochem, Merk Chemicals Ltd, Nottingham, UK) or different concentrations of simvastatin (a gift from Merck, Sharpe, and Dohme BV, ...
Papers on GGTI
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation.
Atreya et al., In J Clin Invest, Feb 2016
Functionally, we found that mice with conditional loss of Rhoa or the gene encoding GGTase-I, Pggt1b, in IECs exhibit spontaneous chronic intestinal inflammation with accumulation of granulocytes and CD4+ T cells.
Rho GTPase Signaling Promotes Constitutive Expression and Release of TGF-β2 by Human Trabecular Meshwork Cells.
Stubbs et al., United States. In Exp Eye Res, Jan 2016
Disrupting monomeric GTPase post-translational prenylation and activation with lovastatin or GGTI-298 markedly reduced constitutive TGF-β2 expression and release.
The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain.
Zhou et al., Xuzhou, China. In Mol Neurobiol, Jan 2016
Such a modification process, catalyzed by protein prenyltransferase including farnesyltransferase (FT), geranylgeranyltransferase I (GGTI), and geranylgeranyltransferase II (GGTII), is required for the transforming activity of many oncogenic proteins, including some RAS family members.
Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia.
Zhou et al., Xuzhou, China. In Neuropharmacology, Jan 2016
Here we reported that astrocyte geranylgeranyltransferase I (GGTI)-mediated Rac1 activation up-regulated NF-κB expression and promoted the neuronal apoptosis after oxygen-glucose deprivation followed by oxygen-glucose regeneration (OGD/R).
Protein Geranylgeranyltransferase Type 1 as a Target in Cancer.
Casey et al., Durham, United States. In Curr Cancer Drug Targets, Jan 2016
This review will provide an overview of the CaaX prenyltransferases, the rationale for targeting GGTase-I in cancer in particular, and the current status of GGTase-I inhibitor (GGTI) development.
Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts.
Fu et al., Hangzhou, China. In J Pharmacol Sci, Dec 2015
The inhibitory effect on collagen I expression was reversed by geranylgeraniol, and mimicked by inhibitors of RhoA/Rho kinase pathway including C3 exoenzyme and GGTI-286.
A mouse model of luciferase-transfected stromal cells of giant cell tumor of bone.
Kumta et al., Hong Kong, Hong Kong. In Connect Tissue Res, Nov 2015
We also tested in vivo antitumor effects of Zoledronate (ZOL) and Geranylgeranyl transferase-I inhibitor (GGTI-298) alone or their combinations in Luc-G33-transplanted nude mice.
Modulation of sterol biosynthesis regulates viral replication and cytokine production in influenza A virus infected human alveolar epithelial cells.
Chan et al., Hong Kong, Hong Kong. In Antiviral Res, Jul 2015
We further dissected the antiviral role of different regulators of the sterol metabolism, we showed that Zometa, FPT inhibitor III, but not GGTI-2133 had anti-viral activities against both H5N1 and H1N1 viruses.
Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1).
Kowluru et al., Detroit, United States. In Biochem Pharmacol, Jul 2015
However, GGTI-2147, a specific inhibitor of geranylgeranylation of Rac1, failed to exert any significant effects on HG-induced p38MAPK activation.
Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells.
Tamanoi et al., Kawasaki, Japan. In Plos One, 2014
Loading of geranylgeranyltransferase-I inhibitor (GGTI) generated liposomes with average diameter of 50-100 nm.
Molecular docking and simulation of Curcumin with Geranylgeranyl Transferase1 (GGTase1) and Farnesyl Transferase (FTase).
Reddy et al., Chennai, India. In Bioinformation, 2014
Docking data show that curcumin (from turmeric) has higher binding affinity to GGTase1 than that of established peptidomimetic GGTase1 inhibitors (GGTI) such as GGTI-297, GGTI-298, CHEMBL525185.
Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis.
Tamanoi et al., Los Angeles, United States. In Bmc Cancer, 2014
For assessing the role of proto-oncogene c-Crk as a KRAS effector, we inhibited KRAS in NSCLC cells by a combination of farnesyltransferase inhibitor (FTI) and geranylgeranyltransferase inhibitor (GGTI) and measured p-Crk-II(Ser41) by western blotting.
Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.
Halayko et al., Winnipeg, Canada. In Am J Physiol Lung Cell Mol Physiol, 2012
our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability
Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases.
Young et al., Los Angeles, United States. In J Lipid Res, 2012
deficiencies in either FTase or GGTase-I lead to severe hepatocellular disease. Our studies lay to rest the earlier notion that FTase is dispensable in adult tissues
Targeting protein prenylation for cancer therapy.
Sebti et al., Tampa, United States. In Nat Rev Cancer, 2011
This observation prompted the development of inhibitors of farnesyltransferase (FT) and geranylgeranyl-transferase 1 (GGT1) as potential anticancer drugs.
Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice.
Bergo et al., Göteborg, Sweden. In J Clin Invest, 2011
Data show that mice lacking GGTase-I in macrophages develop severe joint inflammation resembling erosive rheumatoid arthritis.
Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.
Härkönen et al., Turku, Finland. In Cell Biol Int, 2010
RNAi knockdown of GGTase-Ibeta inhibited invasion, disrupted F-actin organization and decreased the level of cofilin in PC-3 cells.
Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.
Young et al., Los Angeles, United States. In Hum Mol Genet, 2010
Both Fntb and Pggt1b are required for the homeostasis of skin keratinocytes.
Rho GTPases: promising cellular targets for novel anticancer drugs.
Kaina et al., Mainz, Germany. In Curr Cancer Drug Targets, 2006
Inhibitors of farnesyltransferase (FTI), geranylgeranyltransferase (GGTI) as well as of HMG-CoA-reductase (i.
Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis.
Galper et al., Boston, United States. In Stem Cell Rev, 2005
Furthermore, GGTI, a specific inhibitor of GGPP, mimicked the effect of simvastatin of tube formation and the formation of honeycombs whereas FTI, a specific inhibitor of the farnesylation of Ras, had no effect.
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