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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Gamma-glutamyltransferase 5

GGL, gamma-glutamyl leukotrienase, GGT-rel, GGTLA1, GGT5
involved in protecting the lungs from stress due to oxidation or other types of toxics [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: RGS, CAN, RGS9, RGS7, HAD
Papers on GGL
Protein contact prediction by integrating joint evolutionary coupling analysis and supervised learning.
Xu et al., Chicago, United States. In Bioinformatics, Dec 2015
RESULTS: This article presents a group graphical lasso (GGL) method for contact prediction that integrates joint multi-family EC analysis and supervised learning to improve accuracy on proteins without many sequence homologs.
Immunolabeling of gamma-glutamyl transferase 5 in normal human tissues reveals that expression and localization differ from gamma-glutamyl transferase 1.
Wirsig-Wiechmann et al., Oklahoma City, United States. In Histochem Cell Biol, May 2015
Gamma-glutamyl transferase (GGT5) was discovered due to its ability to convert leukotriene C4 (LTC4, a glutathione S-conjugate) to LTD4 and may have an important role in the immune system.
Identification of metabolic signatures associated with erlotinib resistance of non-small cell lung cancer cells.
Koh et al., Shizuoka, Japan. In Anticancer Res, 2014
Copy number gains in v-myc avian myelocytomatosis viral oncogene homolog (MYC), glutathione-S-transferase theta 2 (GSTT2), gamma-glutamyltransferase 1 (GGT1), and GGT5 were also detected, suggesting that amplification of these genes confers glutamine addiction in PC-9ER cells.
Identification of novel molecular markers for prognosis estimation of acute myeloid leukemia: over-expression of PDCD7, FIS1 and Ang2 may indicate poor prognosis in pretreatment patients with acute myeloid leukemia.
Meng et al., Guangzhou, China. In Plos One, 2013
For further improving the prognosis evaluation system, we investigated the transcripts levels of PDCD7, FIS1, FAM3A, CA6, APP, KLRF1, ATCAY, GGT5 and Ang2 in 97 AML patients and 30 non-malignant controls, and validated using the published microarray data from 225 cytogenetically normal AML (CN-AML) patients treated according to the German AMLCG-1999 protocol.
Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes.
Hanigan et al., Oklahoma City, United States. In Anal Biochem, 2011
Two cell surface enzymes that metabolize gamma-glutamyl compounds have been identified: gamma-glutamyl transpeptidase (GGT1) and gamma-glutamyl leukotrienase (GGT5).
Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7.
Slepak et al., Miami, United States. In Biochemistry, 2010
RGS7 consists of three distinct structural entities: the DEP domain and its extension DHEX, the Ggamma-like (GGL) domain, which is permanently bound to Gbeta subunit Gbeta(5), and the RGS domain responsible for the interaction with Galpha subunits.
Characterization of the dwg mutations: dwg and dwg(Bayer) are new mutant alleles of the Ggt1 gene.
Kunieda et al., Okayama, Japan. In Mamm Genome, 2009
Furthermore, dwg (Bayer)/dwg (Bayer) mice had a 46.7-kb deletion containing complete coding sequences of Ggt1 and AI646023 genes and the first exon of the Ggt5 gene, which is closely related to the Ggt1 gene as a member of the GGT gene family.
RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2009
Regulator of G protein signaling 11 (RGS11) is the least characterized member of the R7 family of Ggamma-like GGL domain-containing RGS proteins.
The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.
Slepak et al., Miami, United States. In Biochemistry, 2009
For example, members of the R7 family of RGS proteins contain a DEP, GGL, and novel DHEX domain and are obligatory dimers with G protein beta subunit Gbeta5.
Structure, function, and localization of Gβ5-RGS complexes.
Slepak, Miami, United States. In Prog Mol Biol Transl Sci, 2008
These protein complexes are only found in neurons and are defined by the presence of three domains: DEP/DHEX, Gβ5/GGL, and RGS.
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling.
Martemyanov et al., Minneapolis, United States. In Cell Biochem Biophys, 2008
Four proteins in this group, RGS6, RGS7, RGS9, and RGS11, share a common molecular organization of three modules: (i) the catalytic RGS domain, (ii) a GGL domain that recruits G beta(5), an outlying member of the G protein beta subunit family, and (iii) a DEP/DHEX domain that mediates interactions with the membrane anchor proteins R7BP and R9AP.
The role of Gβ5 in vision.
Chen et al., Richmond, United States. In Prog Mol Biol Transl Sci, 2008
Unlike conventional Gβsthat form dimers with Gγ, Gβ5 partners with R7RGS proteins, which contain the G-protein gamma-like (GGL) domain, to act as a GTPase accelerating protein (GAP) complex on certain Gα subunits.
SNP, ARMS and SSH authentication of medicinal Dendrobium officinale KIMURA et MIGO and application for identification of Fengdou drugs.
Li et al., Nanjing, China. In Biol Pharm Bull, 2008
The remainder two populations (JSR, GGL) with the same sequences could be authenticated by SSH.
The G betagamma dimer as a novel source of selectivity in G-protein signaling: GGL-ing at convention.
Hooks et al., Chapel Hill, United States. In Mol Interv, 2004
The novel functions of G beta(5), in complex with proteins of the GGL domain-containing R7 subfamily of regulators of G protein signaling, are discussed in detail, with specific focus on the potential of the G beta(5)-RGS9-2 pair as a therapeutic target in Parkinson's disease.
Physiological actions of regulators of G-protein signaling (RGS) proteins.
Kurachi et al., Suita, Japan. In Life Sci, 2004
For the latter mechanism, additional regulatory modules, such as PDZ, PX, and G-protein gamma subunit-like (GGL) domains, identified in several RGS proteins may be responsible: (i) PDZ domain of RGS12 interacts with a G-protein-coupled chemokine receptor, CXCR2, and thus facilitates its GAP action on CXCR2-mediated G-protein signals.
Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.
Lieberman et al., Houston, United States. In Am J Pathol, 2002
plays an important role in inflammatory processes
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