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Golgi-associated, gamma adaptin ear containing, ARF binding protein 1

GGA1, Gga1p
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GGA2, p16, GGA3, CAN, beta-secretase
Papers using GGA1 antibodies
Functional equivalents of interferon-mediated signals needed for induction of an mRNA can be generated by double-stranded RNA and growth factors.
Lau Andy, In PLoS ONE, 1986
... ; GGA1 [12]; AP-1γ mouse monoclonal antibody (mAb100/3, Sigma-Aldrich); CALM (C-18, Santa Cruz Biotechnology).
Papers on GGA1
An Analog-Sensitive Version of the Protein Kinase Slt2 Allows Identification of Novel Targets of the Yeast Cell Wall Integrity Pathway.
Martín et al., Madrid, Spain. In J Biol Chem, Feb 2016
Moreover, we identified the calcineurin regulator Rcn2, the 4E-BP translation repressor protein Caf20, and the Golgi-associated adaptor Gga1 as novel targets for Slt2.
Induced oligomerization targets Golgi proteins for degradation in lysosomes.
Linstedt et al., Pittsburgh, United States. In Mol Biol Cell, Jan 2016
To determine how GPP130 is redirected to lysosomes, we tested the role of GGA1 and clathrin, which mediate sorting in the canonical Golgi-to-lysosome pathway.
Intrachromosomal rearrangements in two representatives of the genus Saltator (Thraupidae, Passeriformes) and the occurrence of heteromorphic Z chromosomes.
Gunski et al., Belém, Brazil. In Genetica, Oct 2015
As these rearrangements are found in both suborders of Passeriformes (Oscines and Suboscines), we propose that the fission of GGA1 and inversions in GGA1q have occurred very early after the radiation of this order.
Using Targeted Resequencing for Identification of Candidate Genes and SNPs for a QTL Affecting the pH Value of Chicken Meat.
De Koning et al., Uppsala, Sweden. In G3 (bethesda), Oct 2015
Using targeted genetical genomics, a quantitative trait locus (QTL) affecting the initial postmortem pH value of chicken breast muscle (Pectoralis major) on chromosome 1 (GGA1) recently was fine-mapped.
Genome-wide association study of growth traits in Jinghai Yellow chicken hens using SLAF-seq technology.
Han et al., Yangzhou, China. In Anim Genet, Oct 2015
Another SNP on GGA1, located in the INTS6 gene, had the strongest association with late body weight (weeks 10-16).
Genome-wide association study revealed a promising region and candidate genes for eggshell quality in an F2 resource population.
Yang et al., Beijing, China. In Bmc Genomics, 2014
Most significant loci were in a region spanning from 57.3 to 71.4 Mb of chromosome 1 (GGA1), which together account for 8.4 ~ 16.5% of the phenotypic variance for ESW from 32 to 72 weeks of age, 4.1 ~ 6.9% and 2.95 ~ 16.1% for EST and ESS from 40 to 72 weeks of age.
Identification of quantitative trait loci for body temperature, body weight, breast yield, and digestibility in an advanced intercross line of chickens under heat stress.
Lamont et al., Ames, United States. In Genet Sel Evol, 2014
We identified QTL for BT on Gallus gallus chromosome (GGA)14, 15, 26, and 27; BW on GGA1 to 8, 10, 14, and 21; dry matter digestibility on GGA19, 20 and 21; and QTL of very large effect for breast muscle yield on GGA1, 15, and 22 with a single 1-Mb window on GGA1 explaining more than 15 % of the genetic variation.
Genome-wide association study and biological pathway analysis of the Eimeria maxima response in broilers.
Bed'Hom et al., Paris, France. In Genet Sel Evol, 2014
The highly significant SNPs were associated with body weight gain (three SNPs on GGA5, one SNP on GGA1 and one SNP on GGA3), plasma coloration measured as optical density at wavelengths in the range 465-510 nm (10 SNPs and all on GGA10) and the percentage of β2-globulin in blood plasma (15 SNPs on GGA1 and one SNP on GGA2).
Genome-wide association study of growth traits in the Jinghai Yellow chicken.
Wang et al., Yangzhou, China. In Genet Mol Res, 2014
on GGA1 affecting 3 growth traits (BW4, BW14, and BW16).
Genetic parameters and mapping quantitative trait loci associated with tibia traits in broilers.
Munari et al., Jaboticabal, Brazil. In Genet Mol Res, 2014
Eight QTL were mapped on Gallus gallus chromosomes (GGA): GGA1, GGA4, GGA6, GGA13, and GGA24.
Detection of QTL controlling feed efficiency and excretion in chickens fed a wheat-based diet.
Narcy et al., France. In Genet Sel Evol, 2014
Nine of these QTL were genome-wide significant (four for feed intake on GGA1, one for feed efficiency on GGA2, and four for anatomy on GGA1, 2, 3 and 4).
Genome-wide association studies for feed intake and efficiency in two laying periods of chickens.
Yang et al., Beijing, China. In Genet Sel Evol, 2014
Of particular interest, eight SNPs on GGA1 in the region between 169.23 and 171.55 Mb were consistently associated with FI in both univariate and bivariate GWAS, which explained 3.72 and 2.57 % of the phenotypic variance of FI1 and FI2, respectively.
Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
Tesco et al., Boston, United States. In J Neurosci, 2012
depletion of GGA1 and GGA3 engender a rapid and robust elevation of BACE1 in the acute phase after brain injury.
Expression of coat proteins changes during postnatal development in selected areas of the rat brain.
Sosa et al., Mendoza, Argentina. In Int J Dev Neurosci, 2012
the expression of the GGA1 increased substantially between the 15th and 30th day after birth in all areas studied, excepting the cerebellum and cortex.
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
Evin et al., Melbourne, Australia. In J Neurochem, 2012
Phosphorylation of Ser498 facilitates BACE1 recognition by GGA1 for retrieval to the endosome.
Defects in cellular sorting and retroviral assembly induced by GGA overexpression.
Freed et al., Frederick, United States. In Bmc Cell Biol, 2008
GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs.
The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.
Bonifacino et al., Bethesda, United States. In Mol Biol Cell, 2007
p56 tightly cooperates with the GGAs in the sorting of cathepsin D to lysosomes, probably by enabling the movement of GGA-containing transport carriers.
Molecular basis for autoregulatory interaction between GAE domain and hinge region of GGA1.
Wakatsuki et al., Tsukuba, Japan. In Traffic, 2007
the interaction between the hinge region and the GAE domain underlies the autoregulation of GGA function in clathrin-mediated trafficking through competing with the accessory proteins and the AP-1 complex
Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.
Kornfeld et al., Saint Louis, United States. In Science, 2002
Further, AP-1 contained bound casein kinase-2 that phosphorylated GGA1 and GGA3, thereby causing autoinhibition.
Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.
Wakatsuki et al., Tsukuba, Japan. In Nature, 2002
X-ray structure of the GGA1 VHS domain alone, and in complex with the carboxy-terminal peptide of cation-independent mannose 6-phosphate receptor containing an ACLL sequence
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