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Glial cell line derived neurotrophic factor family receptor alpha 2

GFRalpha2, GFRA2
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: GDNF, RET, Acetyl-CoA Carboxylase, GFRalpha1, GFRalpha3
Papers on GFRalpha2
A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain.
Smith et al., Dundee, United Kingdom. In Eur J Pain, Mar 2015
We identified a cluster in the Chr8p21.3, next to GFRA2 with a lowest p-value of 1.77 × 10(-7) at rs17428041.
Core promoter short tandem repeats as evolutionary switch codes for primate speciation.
Kazeminasab et al., Tehrān, Iran. In Am J Primatol, 2015
The identified genes are involved in important evolutionary and developmental processes, such as normal craniofacial development (TFAP2B), regulation of cell shape (PALMD), learning and long-term memory (RGS14), nervous system development (GFRA2), embryonic limb morphogenesis (PBX2), and forebrain development (APAF1).
Connecting rules from paired miRNA and mRNA expression data sets of HCV patients to detect both inverse and positive regulatory relationships.
Li et al., In Bmc Genomics, 2014
In particular, it was revealed that GFRA2 is positively regulated by miR-557, miR-765 and miR-17-3p that probably bind at different locations of the 5' UTR of this mRNA.
Expression of glial cell line-derived neurotrophic factor and its receptors in cultured retinal Müller cells under high glucose circumstance.
Li et al., Shanghai, China. In Anat Rec (hoboken), 2012
Synthesis of GFRa2 protein is enhanced in Muller cells at 24 hr in experimental diabetic retinopathy, and then the level of GFRa2 protein is downregulated.
Craniopharyngiomas express embryonic stem cell markers (SOX2, OCT4, KLF4, and SOX9) as pituitary stem cells but do not coexpress RET/GFRA3 receptors.
Alvarez et al., Santiago de Compostela, Spain. In J Clin Endocrinol Metab, 2012
Recently, stem/progenitor cells in the rodent and human pituitary have been characterized as expressing GFRA2/RET, PROP1, and stem cell markers such as SOX2 and OCT4 (GPS cells).
Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms.
Too et al., Singapore, Singapore. In Cell Signal, 2011
Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms.
Pituitary stem cell update and potential implications for treating hypopituitarism.
Camper et al., Ann Arbor, United States. In Endocr Rev, 2011
Recent reports have relied on different markers, including SOX2, nestin, GFRa2, and SCA1, to identify pituitary stem cells and progenitors.
Sciatic nerve injury in adult rats causes distinct changes in the central projections of sensory neurons expressing different glial cell line-derived neurotrophic factor family receptors.
Osborne et al., Sydney, Australia. In J Comp Neurol, 2010
Most small unmyelinated neurons in adult rat dorsal root ganglia (DRG) express one or more of the coreceptors targeted by glial cell line-derived neurotrophic factor (GDNF), neurturin, and artemin (GFRalpha1, GFRalpha2, and GFRalpha3, respectively).
Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response.
Wong et al., Belo Horizonte, Brazil. In J Psychiatr Res, 2010
This study found nominally-significant evidence for interactions between GFRA1, 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.
Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia.
Wong et al., Toronto, Canada. In Psychopharmacology (berl), 2010
GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia.
Genetic evidence for a role of IL33 in nasal polyposis.
Lambrechts et al., Leuven, Belgium. In Allergy, 2010
METHODS: We recruited 284 patients with NP in four participating hospitals in Belgium and 427 healthy controls, and genotyped 10 SNPs affecting eosinophilia (rs1420101 in IL1RL1, rs12619285 in IKZF2, rs4431128 in GATA2, rs4143832 in IL5, rs3184504 in SH2B3, rs2416257 in WDR36, rs2269426 in MHC, rs9494145 in MYB, rs748065 in GFRA2, and rs3939286 in IL33) using MALDI-TOF.
Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling.
Carroll et al., Montpellier, France. In Neuron, 2010
Here, we show that specific types of LTMs can be identified shortly after DRG genesis by unique expression of the MafA transcription factor, the Ret receptor and coreceptor GFRalpha2, and find that their specification is Ngn2 dependent.
Absence of pain with hyperhidrosis: a new syndrome where vascular afferents may mediate cutaneous sensation.
Rice et al., Liverpool, United Kingdom. In Pain, 2010
This subject had no mutations in the genes SCN9A, SCN10A, SCN11A, NGFB, TRKA, NRTN and GFRA2.
Functional role of the RET dependence receptor, GFRa co-receptors and ligands in the pituitary.
Alvarez et al., Santiago de Compostela, Spain. In Front Horm Res, 2009
Recent data suggest that RET can also have a second role in pituitary plasticity through a second co-receptor GFRa2.
The effect of interferon-beta on mouse neural progenitor cell survival and differentiation.
Mao-Draayer et al., Burlington, United States. In Biochem Biophys Res Commun, 2009
However, IFN-beta treated mouse NPCs demonstrated decreased apoptosis upon growth factor withdrawal. Pathway-specific polymerase chain reaction (PCR) arrays demonstrated that IFN-beta treatment upregulated the STAT 1 and 2 signaling pathway, as well as GFRA2, NOD1, Caspases 1 and 12, and TNFSF10.
Alteration of glial cell line-derived neurotrophic factor family receptor alpha-2 mRNA expression and its co-expression with neuronal nitric oxide synthase in pelvic ganglia following unilateral cavernous nerve injury.
Tsukamoto et al., Sapporo, Japan. In Int J Urol, 2008
GAP43 mRNA expression moderately increased in the intact Major pelvic ganglia, and GFRalpha2 mRNA was maintained in the intact MPG but not in the injured one.
Evolution of the GDNF family ligands and receptors.
Hätinen et al., Helsinki, Finland. In Brain Behav Evol, 2005
Frog GFRalpha2 has selectively evolved possibly to accommodate GDNF as a ligand.
GDNF - a stranger in the TGF-beta superfamily?
Saarma, Helsinki, Finland. In Eur J Biochem, 2000
GFRalpha1, GFRalpha2, GFRalpha3 and GFRalpha4 are the physiological coreceptors for GDNF, neurturin, artemin and persephin, respectively.
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