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Tripartite motif containing 8

GERP, Trim-8, glioblastoma expressed RING finger protein
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Trim, CIs, p53, V1a, Ubiquitin
Papers on GERP
Recombination in diverse maize is stable, predictable, and associated with genetic load.
Buckler et al., Beijing, China. In Proc Natl Acad Sci U S A, Apr 2015
Finally, using genomic evolutionary rate profiling (GERP) to identify putative deleterious polymorphisms, we find evidence for reduced genetic load in hotspot regions, a phenomenon that may have considerable practical importance for breeding programs worldwide.
Evolutionary conservation of a molecular machinery for export and expression of mRNAs with retained introns.
Hammarskjold et al., Charlottesville, United States. In Rna, Mar 2015
Using GERP analysis, CTEs with strong primary sequence homology, predicted to display identical secondary structure, were identified in NXF genes from >30 mammalian species.
Value of the Gastroesophageal Reflux Disease Questionnaire (GerdQ) in predicting the proton pump inhibitor response in coronary artery disease patients with gastroesophageal reflux-related chest pain.
Tang et al., Suining, China. In Dis Esophagus, Mar 2015
UNASSIGNED: Chest pain experienced by patients with coronary artery disease can be partly due to gastroesophageal reflux-induced chest pain (GERP).
The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex.
Palecek et al., Brno, Czech Republic. In Cell Cycle, 2014
We identified a number of potential MAGE-RING interactions and confirmed several of them (MDM4, PCGF6, RNF166, TRAF6, TRIM8, TRIM31, TRIM41) in co-immunoprecipitation experiments.
TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival.
Merla et al., San Giovanni Rotondo, Italy. In Bmc Cancer, 2014
Here, we investigated the effect of TRIM8 gene in glioma.
Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach.
Ancuta et al., Montréal, Canada. In Retrovirology, 2014
A meta-analysis using the NCBI HIV Interaction Database revealed a set of Th17-specific HIV dependency factors (HDFs): PARG, PAK2, KLF2, ITGB7, PTEN, ATG16L1, Alix/AIP1/PDCD6IP, LGALS3, JAK1, TRIM8, MALT1, FOXO3, ARNTL/BMAL1, ABCB1/MDR1, TNFSF13B/BAFF, and CDKN1B.
TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma.
Tullo et al., Bari, Italy. In Oncotarget, 2014
Recently, we identified TRIM8 as a new p53 modulator, which stabilizes p53 impairing its association with MDM2 and inducing the reduction of cell proliferation.
Integrating multiple genomic data to predict disease-causing nonsynonymous single nucleotide variants in exome sequencing studies.
Jiang et al., Beijing, China. In Plos Genet, 2014
Based on six functional effect scores calculated by existing methods (SIFT, PolyPhen2, LRT, MutationTaster, GERP and PhyloP) and five association scores derived from a variety of genomic data sources (gene ontology, protein-protein interactions, protein sequences, protein domain annotations and gene pathway annotations), SPRING calculates the statistical significance that an SNV is causative for a query disease and hence provides a means of prioritizing candidate SNVs.
Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT.
Broberg et al., Lund, Sweden. In Plos One, 2012
In the Argentinean women, the major AS3MT haplotype, associated with more efficient arsenic metabolism, showed increased methylation of AS3MT (p = 10(-6)) and also differential methylation of several other genes within about 800 kilobasepairs: CNNM2 (p<10(-16)), NT5C2 (p<10(-16)), C10orf26 (p = 10(-8)), USMG5 (p = 10(-5)), TRIM8 (p = 10(-4)), and CALHM2 (p = 0.038) (adjusted for multiple comparisons).
The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes.
Gattei et al., Italy. In Leukemia, 2012
The enforced expression of miR-17, a major member from this family, reduced the expression of the tumor suppressor genes E2F5, TP53INP1, TRIM8 and ZBTB4, and protected cells from serum-free-induced apoptosis (P ≤ 0.05).
TRIM8 modulates p53 activity to dictate cell cycle arrest.
Tullo et al., Bari, Italy. In Cell Cycle, 2012
TRIM8 is a p53 direct target gene that induces p53 stabilization and promotes the degradation of MDM2 protein.
Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-κB pathway.
Singh et al., India. In Plos One, 2011
In the current study, we investigated the role of TRIM8, member of RING family ubiquitin ligase in regulation of NF-κB pathway.
Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination.
Wang et al., Wuhan, China. In Proc Natl Acad Sci U S A, 2011
Tripartite motif 8 (TRIM8) modulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by targeting TAK1 for K63-linked polyubiquitination.
TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells.
Hatakeyama et al., Sapporo, Japan. In Biochim Biophys Acta, 2011
TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells.
TRIM8 modulates STAT3 activity through negative regulation of PIAS3.
Hatakeyama et al., Sapporo, Japan. In J Cell Sci, 2010
These findings indicate that TRIM8 enhances the STAT3-dependent signal pathway by inhibiting the function of PIAS3.
Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma.
Tetè et al., Ferrara, Italy. In Transl Res, 2007
Among genes correlated to nodal metastatic progression, we verified in vitro that NM23-H3 reduced cell motility and TRIM8 were a growth suppressor.
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