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Nuclear receptor subfamily 6, group A, member 1

germ cell nuclear factor, GCNF, NR6A1
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses at least alternatively spliced transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, SF-1, SET
Papers on germ cell nuclear factor
Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells.
Cooney et al., Austin, United States. In J Biol Chem, Feb 2016
Here we show that expression of human Oct4 is directly repressed by germ cell nuclear factor (GCNF), an orphan nuclear receptor, in hES cells.
NR6A1 couples with cAMP response element binding protein and regulates vascular smooth muscle cell migration.
Zhang et al., Shanghai, China. In Int J Biochem Cell Biol, Dec 2015
Nuclear receptor subfamily 6, group A, member 1 (NR6A1) is involved in regulating embryonic stem cell differentiation, reproduction, neuronal differentiation.
Germ Cell Nuclear Factor (GCNF/RTR) Regulates Transcription of Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in Testicular Germ Cells-The Androgen Connection.
Dufau et al., Bethesda, United States. In Mol Endocrinol, Dec 2015
This study identifies a functional cis-binding element on the GRTH gene for GC nuclear factor (GCNF) (GCNF/RTR) required to regulate GRTH gene expression in postmeiotic testis GCs and explore the action of androgen on GCNF and GRTH transcription/expression.
In vitro generation and characterization of chicken long-term germ cells from different embryonic origins.
Pain et al., Bron, France. In Theriogenology, Oct 2015
Molecular characterization shows that these selected and amplified clusters show a PGC-like cell profile, as they express cPOUV (a pluripotent-associated marker), NR6A1/GCNF and DDX4/CVH (germ cell-specific genes).
Genome-wide identification, evolution and expression analysis of nuclear receptor superfamily in Nile tilapia, Oreochromis niloticus.
Wang et al., Chongqing, China. In Gene, Oct 2015
These duplicates, except those of DAX1, SHP and GCNF found in the elephant shark, were derived from 3R (third round of genome duplication).
Epigallocatechin-3-gallate increases RXRg-mediated pro-apoptotic and anti-invasive effects in gastrointestinal cancer cell lines.
Farabegoli et al., Bologna, Italy. In Curr Cancer Drug Targets, Sep 2015
IIF alone and in combination with EGCG activated the retinoic X response elements and induced the germ cell nuclear factor.
Enriched transcription factor signatures in triple negative breast cancer indicates possible targeted therapies with existing drugs.
Leyland-Jones et al., Sioux Falls, United States. In Meta Gene, Jun 2015
RESULTS: GSEA identified enriched gene expression patterns in TN samples that share common promoter motifs associated with SOX9, E2F1, HIF1A, HMGA1, MYC BACH2, CEBPB, and GCNF/NR6A1.
Allelic frequencies of NR6A1 and VRTN, two genes that affect vertebrae number in diverse pig breeds: a study of the effects of the VRTN insertion on phenotypic traits of a Duroc × Landrace-Large White cross.
In Meat Sci, Feb 2015
A SNP (748 C > T) in the NR6A1 gene and an insertion (g.20311_20312ins291) in the VRTN gene have been shown to affect vertebrae number in the pig.
MC1R, KIT, IGF2, and NR6A1 as markers for genetic differentiation in Thai native, wild boars, and Duroc and Chinese Meishan pigs.
Duangjinda et al., Khon Kaen, Thailand. In Genet Mol Res, 2014
Additional functional marker genes, such as insulin like growth factor-2 (IGF2) and orphan nuclear receptor, germ cell nuclear factor (NR6A1), have been described for variations in factors such as fat deposition, litter size, and vertebra number in pigs.
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.
Lee et al., Houston, United States. In Mol Endocrinol, 2014
The nuclear orphan receptors for which endogenous ligands have not been identified include nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X gene), NR0B2 (small heterodimer partner), NR1D1/2 (Rev-Erbα/β), NR2C1 (testicular receptor 2), NR2C2 (testicular receptor 4), NR2E1 (tailless), NR2E3 (photoreceptor-specific NR [PNR]), NR2F1 chicken ovalbumin upstream promoter transcription factor 1 (COUP-TFI), NR2F2 (COUP-TFII), NR2F6 (v-erbA-related protein), NR4A1 (Nur77), NR4A2 (Nurr1), NR4A3 (Nor1), and NR6A1 (GCNF).
Revisiting the role of GCNF in embryonic development.
Cooney et al., Houston, United States. In Semin Cell Dev Biol, 2013
GCNF (NR6A1) is essential for embryonic development.
The microRNA miR-235 couples blast-cell quiescence to the nutritional state.
Katada et al., Tokyo, Japan. In Nature, 2013
Upregulation of one of the miR-235 targets, nhr-91, which encodes an orthologue of mammalian germ cell nuclear factor, is responsible for defects caused by loss of the miRNA.
The role of nuclear receptors in embryonic stem cells.
Cooney et al., Houston, United States. In Adv Exp Med Biol, 2012
LRH1, DAX1, Esrrβ and TR2 play critical roles in maintaining pluripotency, while, GCNF, COUP-TFs and sumoylated TR2 are critical in regulating the exit from pluripotency.
Recent progresses in identifying nuclear receptors and their families.
Chou et al., Jingdezhen, China. In Curr Top Med Chem, 2012
According to their different action mechanisms or functions, NR superfamily has been classified into seven families: NR1 (thyroid hormone like), NR2 (HNF4-like), NR3 (estrogen like), NR4 (nerve growth factor IB-like), NR5 (fushi tarazu-F1 like), NR6 (germ cell nuclear factor like), and NR0 (knirps or DAX like).
Differential recruitment of methyl CpG-binding domain factors and DNA methyltransferases by the orphan receptor germ cell nuclear factor initiates the repression and silencing of Oct4.
Cooney et al., Houston, United States. In Stem Cells, 2011
GCNF initiates the repression and epigenetic modification of Oct4 gene during ESC differentiation.
Transcriptional regulation of the hypocretin/orexin gene by NR6A1.
Mignot et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2011
These experiments confirmed that NR6A1 works as a regulator for hypocretin transcription.
Extra-germ cell expression of mouse nuclear receptor subfamily 6, group A, member 1 (NR6A1).
Cooney et al., Louisville, United States. In Biol Reprod, 2009
Nr6a1 is expressed not only in the germ cells of mouse but also in a variety of somatic tissues, including epididymis, oviduct, brain, and pituitary.
Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage.
van der Kooy et al., Toronto, Canada. In J Neurosci, 2009
The suppression of Oct4 by GCNF is important for the transition from primitive to definitive neural stem cells and restriction of the non-neural competency in the early neural stem cell lineage.
Germ cell nuclear factor directly represses the transcription of peroxisome proliferator-activated receptor delta gene.
Kang et al., Jinan, China. In Acta Biochim Biophys Sin (shanghai), 2008
These results suggested that GCNF might be a negative regulator of PPARdelta gene expression through its direct interaction with PPARdelta promoter in mouse testis.
Orphan nuclear receptor function in the ovary.
Lan et al., Louisville, United States. In Front Biosci, 2006
Orphan nuclear receptors such as germ cell nuclear factor (GCNF), steroidogenic factor 1 (SF-1) and liver receptor homolog-1 (LRH-1), are emerging as important ovarian factors in regulating female reproduction.
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