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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Gemin4, HCAP1, HC56
The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SmaI, SIP1, Cdc4, Gy-1, CAN
Papers on Gemin4
Long-term exposure to black carbon, cognition and single nucleotide polymorphisms in microRNA processing genes in older men.
Baccarelli et al., Boston, United States. In Environ Int, Jan 2016
95%CI: (1.39, 2.85)) and minor variant carriers of GEMIN4 rs2740348 (OR=1.34;
GEMIN4 functions as a coregulator of the mineralocorticoid receptor.
Young et al., Ōita, Japan. In J Mol Endocrinol, Apr 2015
Gem (nuclear organelle)-associated protein 4 (GEMIN4) is one of the proteins that contain this motif.
Association of microRNA biogenesis pathway gene variants and alcohol dependence risk.
Herken et al., Mercin, Turkey. In Dna Cell Biol, Mar 2015
G alleles have significantly altered the risk for AD, and also there is a significant association of GEMIN4 rs910924 (χ(2) = 5.291, p = 0.021; OR = 1.913, 95% CI: 1.094-3.344)
Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families.
Alkuraya et al., Riyadh, Saudi Arabia. In Cell Rep, Feb 2015
This prescreening step led to the identification of 69 recessive genes not previously associated with disease, of which 33 are here described (SPDL1, TUBA3E, INO80, NID1, TSEN15, DMBX1, CLHC1, C12orf4, WDR93, ST7, MATN4, SEC24D, PCDHB4, PTPN23, TAF6, TBCK, FAM177A1, KIAA1109, MTSS1L, XIRP1, KCTD3, CHAF1B, ARV1, ISCA2, PTRH2, GEMIN4, MYOCD, PDPR, DPH1, NUP107, TMEM92, EPB41L4A, and FAM120AOS).
Single-nucleotide polymorphisms of microRNA processing machinery genes and risk of colorectal cancer.
Guo et al., Shijiazhuang, China. In Onco Targets Ther, 2014
We genotyped 6 miR-SNPs of miRNA processing machinery genes including XPO5 (rs11077), RAN (rs14035), Dicer (rs3742330), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348) in a case-control study to evaluate their impact on colorectal cancer (CRC) risk.
Single nucleotide polymorphisms of microRNA processing genes and outcome of non-Hodgkin's lymphoma.
Guo et al., Shijiazhuang, China. In Onco Targets Ther, 2014
Five miR-SNPs in miRNA processing machinery genes, including XPO5 (rs11077), RAN (rs14035), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348), in 168 non-Hodgkin's lymphoma (NHL) patients were evaluated for their association with the cancer risk and outcomes associated with NHL.
Single-nucleotide polymorphisms of microRNA processing machinery genes are associated with risk for gastric cancer.
Guo et al., Shijiazhuang, China. In Onco Targets Ther, 2014
In this study, we investigated six miR-SNPs in microRNA processing machinery genes, including rs11077 of the XPO5 gene, rs14035 of the RAN gene, rs3742330 of the Dicer gene, rs9623117 of the TNRC6B gene, rs197412 of the GEMIN3 gene, and rs2740348 of the GEMIN4 gene, in gastric cancer patients and subsequently evaluated their potential roles in gastric cancer risk in a case control study.
Association between SNPs in miRNA-machinery genes and chronic hepatitis B in the Chinese Han population.
Ying et al., Chengdu, China. In Infect Genet Evol, 2014
To explore the relationship between three SNPs (rs3757 in DGCR8, rs636832 in AGO1, rs7813 in GEMIN4) in miRNA-machinery genes and chronic hepatitis B, we genotyped the SNPs by high resolution melting method (HRM) in a case-control study of 332 unrelated chronic hepatitis B patients and 352 unrelated healthy controls in Western China.
MicroRNAs related polymorphisms and genetic susceptibility to esophageal squamous cell carcinoma.
Dai et al., Zhengzhou, China. In Mol Genet Genomics, 2014
To evaluate the association between microRNA-related SNPs and EC, a case-control study including 381 patients with esophageal squamous cell carcinoma (ESCC) and 426 gender, age-matched controls was carried out to investigate the genetic susceptibility of five microRNA-related SNPs (rs2910164 in microRNA-146a, rs11614913 in microRNA-196a-2, rs7813 in GEMIN4, rs1595066 and rs16845990 in ErbB4) as well as the interactions of gene-gene and gene-environment in the development of ESCC.
Association of miRNA-related genetic polymorphisms and prognosis in patients with esophageal squamous cell carcinoma.
Lee et al., Taipei, Taiwan. In Ann Surg Oncol, 2014
Two other SNPs, rs14035 of RAN and rs7813 of GEMIN4, showed a borderline significant association with the prognosis of ESCC.
[Association of microRNA-related genes (DROSHA, DICER1 and GEMIN4) polymorphisms with T-cell lymphoma prognosis].
Chen et al., Chongqing, China. In Zhonghua Xue Ye Xue Za Zhi, 2014
OBJECTIVE: To analyze the association of micoRNA-related genes DROSHA single nucleotide polymorphisms (SNP) rs10719 and rs6877842, DICER1 rs3742330and GEMIN4 rs3744741 with prognosis of T-cell lymphoma.
Ambient particulate air pollution and microRNAs in elderly men.
Schwartz et al., Boston, United States. In Epidemiology, 2014
We found significant SNP-by-pollutant interactions for rs7813, rs910925, and rs1062923 in GEMIN4 and black carbon and PM2.5 for miR-1, -126, -146a, -222, and -9, and for rs1640299 in DGCR8 and SO4 for miR-1 and -135a.
Single nucleotide polymorphisms of microRNA processing machinery genes and outcome of hepatocellular carcinoma.
Zhao et al., Shijiazhuang, China. In Plos One, 2013
We examined 6 miR-SNPs in miRNA processing machinery genes including exportin 5 (XPO5) (rs11077), Ran-GTPase (RAN) (rs14035), Dicer (rs3742330), Trinucleotide Repeat Containing 6B (TNRC6B) (rs9623117), GEMIN3 (rs197412), GEMIN4 (rs2740348) in 108 surgically resected HCC patients and evaluated the impact of these miR-SNPs on HCC outcome.
Genetic variants in the microRNA machinery gene GEMIN4 are associated with risk of prostate cancer: a case-control study of the Chinese Han population.
Huang et al., Chengdu, China. In Dna Cell Biol, 2012
the association between the GEMIN4 gene and the risk of prostate cancer
Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4.
Young et al., Columbia, United States. In Biochem Biophys Res Commun, 2008
A canonical nuclear import sequence in the N-terminus of Gemin4 was identified.
Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins.
Matera et al., Cleveland, United States. In Proc Natl Acad Sci U S A, 2005
Gemin3 and Gemin4 function in Sm core assembly and correlate the activity of this pathway with Spinal Muscular Atrophy.
Nucleocytoplasmic lectins.
Patterson et al., East Lansing, United States. In Biochim Biophys Acta, 2004
Galectin-1 and galectin-3 have been identified as pre-mRNA splicing factors in the nucleus, in conjunction with their interacting ligand, Gemin4.
Two variants of the human hepatocellular carcinoma-associated HCAP1 gene and their effect on the growth of the human liver cancer cell line Hep3B.
Gu et al., Shanghai, China. In Genes Chromosomes Cancer, 2004
A haplotype of HCAP1 with minor alleles at 5 single nucleotide polymorphisms may be related to cancer susceptibility: its expression causes up-regulation of genes involved in cell growth and down-regulation of genes involved in apoptosis and DNA repair.
Understanding the biochemical activities of galectin-1 and galectin-3 in the nucleus.
Wang et al., East Lansing, United States. In Glycoconj J, 2003
Galectin-1 and galectin-3 bind directly to Gemin4, a component of the SMN core complex, which plays multiple roles in ribonucleoprotein assembly, including the biogenesis, delivery, and recycling of snRNPs to the spliceosome.
HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins.
Gu et al., Shanghai, China. In J Biochem, 2003
zinc-finger proteins were identified as HCAP1-interacting proteins
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