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Rho guanine nucleotide exchange factor

Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
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Top mentioned proteins: RhoA, Rhodopsin, CAN, V1a, Actin
Papers on GEFT
Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar-Kyoto and spontaneously hypertensive rats.
Zicha et al., Praha, Czech Republic. In J Hypertens, Dec 2015
Fasudil effects on contractility of isolated arteries were attenuated in young but not in adult SHR. mRNA expression of selected Rho-GEFs (Arhgef1, Arhgef11 and Arhgef12) was decreased only in adult SHR, whereas p63RhoGEF and CPI-17 expression was reduced in both age groups of SHR.
The blocking of angiotensin II type 1 receptor and RhoA/Rho kinase activity in hypertensive patients: Effect of olmesartan medoxomil and implication with cardiovascular-renal remodeling.
Calò et al., Padova, Italy. In J Renin Angiotensin Aldosterone Syst, Dec 2015
This study evaluates in 15 untreated hypertensive patients the effect of olmesartan treatment on p63RhoGEF, key in Ang II-induced ROCK activation, and MYPT-1 phosphorylation, a marker of ROCK activity.
p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.
Lutz et al., Göttingen, Germany. In J Mol Cell Cardiol, Nov 2015
We hypothesized that the specific mediator of Gq/11-dependent RhoA activation p63RhoGEF, which is expressed in cardiac fibroblasts, plays a role in the underlying processes.
Dynamics of G protein effector interactions and their impact on timing and sensitivity of G protein-mediated signal transduction.
Bünemann et al., Marburg an der Lahn, Germany. In Eur J Cell Biol, Jul 2015
In this review we specifically focus on the interaction of Gαi subunits with adenylyl cyclases and of Gαq subunits with p63RhoGEF or G protein coupled receptor kinases type 2. Comparing the dynamics of these interactions revealed remarkable differences between different G protein effectors regarding the ability to be modulated by members of the regulator of G protein signalling protein family as well as the sensitivity towards receptor activation.
Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state.
Somlyo et al., Charlottesville, United States. In J Biol Chem, May 2015
Finally, EMT is associated with increased p63RhoGEF and RhoGEF-H1 protein expression, increased GEF-H1 activity, with a trend in increased p63RhoGEF activity.
Anti-tumoral effects of miR-3189-3p in glioblastoma.
Peruzzi et al., New Orleans, United States. In J Biol Chem, Apr 2015
In vitro, the functionality of miR-3189-3p was tested by RNA-binding protein immunoprecipitation, and miR-3189-3p coimmunoprecipitated with Argonaute 2 together with two of its major predicted gene targets, the SF3B2 splicing factor and the guanine nucleotide exchange factor p63RhoGEF.
Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ.
Wong et al., Hong Kong, Hong Kong. In Bmc Cancer, 2014
Other effectors of Gαq including RGS2 and p63RhoGEF were unable to interact with Fhit.
Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization.
Goedhart et al., Amsterdam, Netherlands. In Sci Rep, 2014
By employing the FRET sensor we show that a plasma membrane located RhoGEF, p63RhoGEF, can rapidly activate RhoA through endogenous GPCRs and that localized RhoA activity at the cell periphery correlates with actin polymerization.
Gαq signalling: the new and the old.
Ribas et al., Madrid, Spain. In Cell Signal, 2014
Novel effectors include p63RhoGEF, that provides a link between G protein-coupled receptors and RhoA activation, phosphatidylinositol 3-kinase (PI3K), implicated in the regulation of the Akt pathway, or the cold-activated TRPM8 channel, which is directly inhibited upon Gαq binding.
Dynamics of Gαq-protein-p63RhoGEF interaction and its regulation by RGS2.
Bünemann et al., Marburg an der Lahn, Germany. In Biochem J, 2014
p63RhoGEF is known to be specifically activated by Gαq/11 and mediates a major part of the acute response of vascular smooth muscle cells to angiotensin II treatment.
Increased level of p63RhoGEF and RhoA/Rho kinase activity in hypertensive patients.
Rossi et al., Davis, United States. In J Hypertens, 2014
OBJECTIVE: p63RhoGEF, a guanine nucleotide exchange factor, has been reported 'in vitro' as key mediator of the angiotensin II-induced RhoA/Rho kinase activation leading to vasoconstriction and cardiovascular remodeling.
Strike a pose: Gαq complexes at the membrane.
Tesmer et al., Ann Arbor, United States. In Trends Pharmacol Sci, 2014
Gαq functions at the intracellular surface of the plasma membrane, as do its best-characterized targets, phospholipase C-β, p63RhoGEF, and GPCR kinase 2 (GRK2).
Overexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma.
Li et al., Shihezi, China. In Int J Clin Exp Pathol, 2013
We investigated guanine nucleotide exchange factor, GEFT, at expression level in 45 RMS patients and 36 normal striated muscle controls using immunohistochemistry using tissue microarrays.
p63RhoGEF: a new switch for G(q)-mediated activation of smooth muscle.
Somlyo et al., Charlottesville, United States. In Trends Cardiovasc Med, 2012
This review focuses on the function and mechanisms of activation of p63RhoGEF (Arhgef 25; GEFT) recently identified in SM and its possible role in selective targeting of RhoA-mediated regulation of basal blood pressure through agonists that couple through G(αq/11).
p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.
Somlyo et al., Charlottesville, United States. In Circ Res, 2011
Signaling through p63RhoGEF provides a novel mechanism for selective regulation of blood pressure.
Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells.
Tesmer et al., Ann Arbor, United States. In J Biol Chem, 2011
p63RhoGEF is regulated chiefly through allosteric control by Galpha(q), as opposed to other known Galpha-regulated RhoGEFs, which are instead sequestered in the cytoplasm, perhaps because of their high basal activity.
GEFT, A Rho family guanine nucleotide exchange factor, regulates lens differentiation through a Rac1-mediated mechanism.
Li et al., Houston, United States. In Curr Mol Med, 2011
GEFT regulation of lens differentiation and eye development occurs through a Rac1-dependent mechanism.
p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells.
Lutz et al., Heidelberg, Germany. In Faseb J, 2010
Specifically mediates angiotensin II- Gq/11-dependent RhoA activation and downstream signaling and processes in vascular smooth muscle cells
RhoA promotes differentiation of WB-F344 cells into the biliary lineage.
Pei et al., Beijing, China. In Differentiation, 2009
cells with ectopically active RhoA expression were found to form bile-duct-like structures even without Matrigel treatment
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Tesmer et al., Mannheim, Germany. In Science, 2008
the crystal structure of the Galphaq-p63RhoGEF-RhoA complex, detailing the interactions of Galphaq with the Dbl and pleckstrin homology (DH and PH) domains of p63RhoGEF was determined
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