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GDP dissociation inhibitor 2

GDI-2, Rab GDI beta, GDI beta
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rab5, Rhodopsin, fibrillin-1, CAN, HAD
Papers on GDI-2
Identification of Key Proteins in Human Epithelial Cells Responding to Bystander Signals From Irradiated Trout Skin.
Howe et al., Dublin, Ireland. In Dose Response, Jul 2015
The proteomic changes measured in HaCaT cells receiving the ITCM revealed that exposure to 0.5 Gy induced an upregulation of annexin A2 and cingulin and a downregulation of Rho-GDI2, F-actin-capping protein subunit beta, microtubule-associated protein RP/EB family member, and 14-3-3 proteins.
GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.
Zhang et al., Beijing, China. In Plos Biol, Apr 2015
Dzip1 preferentially bound to Rab8GDP and promoted its dissociation from its inhibitor GDI2 at the pericentriolar region, as demonstrated by sucrose gradient centrifugation of purified basal bodies, immunoprecipitation, and acceptor-bleaching fluorescence resonance energy transfer assays.
Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis.
Rajender et al., Lucknow, India. In Plos One, 2014
Some transcripts were specific to the normozoospermic group (up-regulated: CAPNS1, FAM153C, ARF1, CFL1, RPL19, USP22; down-regulated: ZNF90, SMNDC1, c14orf126, HNRNPK), while some were specific to the asthenozoospermic group (up-regulated: RPL24, HNRNPM, RPL4, PRPF8, HTN3, RPL11, RPL28, RPS16, SLC25A3, C2orf24, RHOA, GDI2, NONO, PARK7; down-regulated: HNRNPC, SMARCAD1, RPS24, RPS24, RPS27A, KIFAP3).
Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force.
Liu et al., Xi'an, China. In Sci Rep, 2014
The five proteins identified were plasminogen activator inhibitor 2 (PAI-2, Spot 1), peroxiredoxin-6 (PRD-6, Spot 3), manganese superoxide dismutase (SOD2, Spot 6), Rho GDP-dissociation inhibitor 2 (Rho-GDI2, Spot 11) and L-lactate dehydrogenase B chain (L-LDH, Spot 15).
Annexin A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation.
van de Water et al., Leiden, Netherlands. In Oncogene, 2014
Knockdown of 172 individual endocytosis and actin-regulatory genes with small interfering RNAs led to the identification of 14 genes of which the contribution to EGFR endocytosis in breast cancer is until now poorly defined, including DNAJC6, GDI2, FGD6, HAX1, NECAP2 and AnxA2.
Proteomic analysis of uterine fluid during the pre-implantation period of pregnancy in cattle.
Lonergan et al., Dublin, Ireland. In Reproduction, 2014
Of the most abundant proteins present, iTRAQ analysis revealed that RPB4, TIMP2 and GC had the same expression pattern as IFNT, while the abundance of IDH1, CST6 and GDI2 decreased on either day 16 or 19.
Increased migration of human mesenchymal stromal cells by autocrine motility factor (AMF) resulted in enhanced recruitment towards hepatocellular carcinoma.
Mazzolini et al., Buenos Aires, Argentina. In Plos One, 2013
Stimulation of MSCs with recombinant AMF (rAMF) also induced the in vitro adhesion to endothelial cells in coincidence with changes in the expression levels of MMP3, AMF receptor, caveolin-1, and -2 and GDI-2.
Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma.
Fults et al., Salt Lake City, United States. In Acta Neuropathol Commun, 2013
We analyzed two genes that were sites of frequent transposon insertion and highly expressed in human medulloblastomas: Arnt (aryl hydrocarbon receptor nuclear translocator) and Gdi2 (GDP dissociation inhibitor 2).
Proteomic analysis of NK92-MI cells activated by neuropeptide substance P.
Zaifu et al., Shenyang, China. In Neuropeptides, 2013
Moreover, the protein Rho GDI-2, Protein DJ-1 and alpha-enolase were reconfirmed by western blotting.
The clinical potential of blood-proteomics in multiple sclerosis.
De Donno et al., Lecce, Italy. In Bmc Neurol, 2012
RESULTS: Rho-GDI2, Rab2 and Cofilin1 were found to be associated with down-regulated and naïve group phenotypes; Cortactin and Fibrinogen beta-Chain Precursor were found to be associated with down-regulated and group-related IFN-treated RR-MS phenotypes.
Tamarindus indica extract alters release of alpha enolase, apolipoprotein A-I, transthyretin and Rab GDP dissociation inhibitor beta from HepG2 cells.
Junit et al., Kuala Lumpur, Malaysia. In Plos One, 2011
Five of the spots were subsequently identified as alpha enolase (ENO1), transthyretin (TTR), apolipoprotein A-I (ApoA-I; two isoforms), and rab GDP dissociation inhibitor beta (GDI-2).
Evolution of tumor invasiveness: the adaptive tumor microenvironment landscape model.
Cheng et al., Philadelphia, United States. In Cancer Res, 2011
Microarray and gene depletion studies showed the role of Rho-GDI2 in regulating both cell movement and proliferation.
Association of the Tobacco mosaic virus 126kDa replication protein with a GDI protein affects host susceptibility.
Culver et al., College Park, United States. In Virology, 2011
An interaction between the Tobacco mosaic virus (TMV) 126kDa replication protein and a host-encoded Rab GDP dissociation inhibitor (GDI2) was identified and investigated for its role in infection.
Proteomics-based identification of a group of apoptosis-related proteins and biomarkers in gastric cancer.
Wang et al., Beijing, China. In Int J Oncol, 2011
Western blot analysis confirmed differential expression for 9 proteins, including AGR2, ENO1, GDI2, GRP78, GRP94, PPIA, PRDX1, PTEN and VDAC1.
Identification of nasopharyngeal carcinoma antigens that induce humoral immune response by proteomic analysis.
Chen et al., Changsha, China. In Proteomics Clin Appl, 2007
Among nine identified proteins, cytokeratin 19 (CK19), Erb3 binding protein (EBP1), and Rho GDP dissociation inhibitor-beta (Rho-GDI-2) induced autoantibodies in more than 36.8% of NPC patients but not in healthy individuals.
Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers.
Miao et al., Nanjing, China. In Biochim Biophys Acta, 2007
The increased levels of cyclin I and GDI2 found to be associated with pancreatic carcinoma were further confirmed by Western blot analyses in an independent series of serum samples and/or pancreatic juice samples
[Regulatory mechanism of neurotransmitter release by low-molecular-weight G protein, Rab3A and the regulatory proteins].
Takai et al., In Masui, 2001
role in regulatory mechanism of neurotransmitter release
Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain.
Lubec et al., Vienna, Austria. In J Neural Transm Suppl, 2000
Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain.
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