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Guanine nucleotide binding protein, alpha transducing 3

Top mentioned proteins: ACID, V1a, CAN, OUT, Cholesterol 7-alpha-Hydroxylase
Papers on GDCA
Development of Bile Salt-Resistant Leuconostoc citreum by Expression of Bile Salt Hydrolase Gene.
Han et al., Ch'ŏngju, South Korea. In J Microbiol Biotechnol, Jan 2016
Upon incubation with glycodeoxycholic acid sodium salt (GDCA), the L. citreum transformants grew and formed colonies, successfully transcribed the bsh gene, and expressed the BSH enzyme.
Functional role of oppA encoding an oligopeptide-binding protein from Lactobacillus salivarius Ren in bile tolerance.
Hao et al., Beijing, China. In J Ind Microbiol Biotechnol, Aug 2015
Furthermore, the recombinant strain exhibited 1.8-fold and 3.6-fold higher survival when exposed to the sublethal concentration of sodium taurocholate and sodium taurodeoxycholate, respectively, while no significant change was observed when exposed to sodium glycocholate and sodium glycodeoxycholate (GDCA).
Functional role of tlyC1 encoding a hemolysin-like protein from Bifidobacterium longum BBMN68 in bile tolerance.
Hao et al., Beijing, China. In Fems Microbiol Lett, 2014
Notably, the recombinant strains showed threefold higher survival when exposed to sublethal concentration of TCA and TDCA, while no significant change was observed when exposed to GCA and GDCA.
Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits.
Xu et al., Newark, United States. In Am J Physiol Gastrointest Liver Physiol, 2014
A rabbit model was developed by infusing glycodeoxycholic acid (GDCA) through the splenic vein to bypass ileal FGF19.
Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease.
Cherrington et al., Tucson, United States. In Toxicol Appl Pharmacol, 2013
Conversely, cholic acid (CA) and glycodeoxycholic acid (GDCA) were decreased in NASH liver.
Bile acids affect the growth of human cholangiocarcinoma via NF-kB pathway.
Wang et al., Shanghai, China. In Cancer Invest, 2013
We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth.
Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes.
Hylemon et al., Richmond, United States. In Hepatology, 2012
TCA, taurodeoxycholic acid (TDCA), tauroursodeoxycholic acid (TUDCA), glycocholic acid (GCA), glycodeoxycholic acid (GDCA), and S1P-induced activation of ERK1/2 and AKT were significantly inhibited by JTE-013, a S1P(2) antagonist, in primary rat hepatocytes.
The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY).
Beglinger et al., Switzerland. In Clin Nutr, 2011
The sweet taste receptors (alpha-gustducin and T1R3) are involved in glucose-stimulated secretion of GLP-1 and PYY.
Coexpression of bile salt hydrolase gene and catalase gene remarkably improves oxidative stress and bile salt resistance in Lactobacillus casei.
Hao et al., Beijing, China. In J Ind Microbiol Biotechnol, 2011
Treatment of L. casei CB with various concentrations of sodium glycodeoxycholate (GDCA) showed that ~10(5) CFU/ml cells survived after incubation with 0.5% GDCA, whereas almost all the L. casei CK cells were killed when treaded with 0.4% GDCA.
Impact of bile acids on the growth of human cholangiocarcinoma via FXR.
Wang et al., Shanghai, China. In J Hematol Oncol, 2010
Again, the conjugated bile acid-GDCA promoted the growth of tumor.
[Effects of bile acids on expression of interleukin-6 and cell viability in QBC939 cell line].
Zhang et al., Shanghai, China. In Zhonghua Wai Ke Za Zhi, 2010
METHODS: Human cholangiocarcinoma cells were stimulated with 800 µmol/L bile acid (CA), 100 µmol/L deoxycholate (DCA), 100 µmol/L chenodeoxycholic acid (CDCA), 1200 µmol/L gly acid (GCA), 200 µmol/L glycodeoxycholic acid (GDCA) and 300 µmol/L gly chenodeoxycholic acid (GCDCA).MTT assay and ELISA were used to detect the cell viability and the expression of IL-6 at 24 h, 48 h and 72 h.
Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.
Boekhoff et al., Marburg an der Lahn, Germany. In J Comp Physiol A, 2007
Axonemal-associated localization within the midpiece and principal piece of human spermatozoa raises the possibility that this G protein alpha-subunit may process intracellular signals controlling sperm motility.
Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon.
Rozengurt et al., Los Angeles, United States. In Am J Physiol Gastrointest Liver Physiol, 2006
the alpha-subunit of the taste-specific G protein gustducin is expressed prominently in cells of the human colon
Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.
Hylemon et al., Richmond, United States. In Hepatology, 2005
Deoxycholic acid (DCA), chenodeoxycholic acid (CDCA), taurodeoxycholic acid (TDCA), glycodeoxycholic acid (GDCA), taurochenodeoxycholic acid (TCDCA), glycochenodeoxycholic acid (GCDCA), taurocholic acid (TCA), glycocholic acid (GCA), and tauroursodeoxycholic acid (TUDCA) all activated ERK1/2 in primary rat hepatocytes that was abolished by inhibition of ERBB1, and significantly reduced by ROS quenching agents.
Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor.
Einarsson et al., Huddinge, Sweden. In Hepatology, 2003
Glycochenodeoxycholic acid (GCDCA; 100 micromol/L) significantly decreased formation of cholic acid (CA) to 44% +/- 4% of controls and glycodeoxycholic acid (GDCA) decreased formation of CA to 67% +/- 11% of controls.
Comparison of the effects of bile acids on cell viability and DNA synthesis by rat hepatocytes in primary culture.
Marin et al., Salamanca, Spain. In Biochim Biophys Acta, 2000
By contrast, the ability to inhibit radiolabeled thymidine incorporation into DNA was only slightly lower for taurodeoxycholic acid (TDCA) and glycodeoxycholic acid (GDCA) than for DCA.
Local regulation of ileal tone in healthy humans.
Jian et al., Paris, France. In Am J Physiol, 1997
In six healthy subjects, we studied ileal tonic and phasic motility in response to the infusion into the terminal ileum of different isotonic solutions: saline, glycochenodeoxycholic acid (GDCA), triglycerides, and short-chain fatty acids (SCFA).
Different feedback regulation of hepatic cholesterol and bile acid synthesis by glycodeoxycholic acid in rabbits.
Tint et al., Newark, United States. In Gastroenterology, 1993
BACKGROUND: To explore the sexual difference in the feedback regulation of hepatic bile acid synthesis, glycodeoxycholic acid (GDCA) was administered to 15 male and 14 female rabbits.
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