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Opsin 1

This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: CAN, IL-8, ACID, carboxypeptidase, HAD
Papers using GCP antibodies
Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases.
Hotchin Neil, In PLoS ONE, 2004
... The expression construct for the EGFP-tagged C300 fragment of GCP-WD was generated by insertion into pEGFP-C1 (Clontech).
Papers on GCP
Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection.
Schmuck et al., Essen, Germany. In Angew Chem Int Ed Engl, Feb 2016
Functionalization of the tetracationic cyclic peptide (Ka)4 with a single guanidiniocarbonyl pyrrole (GCP) moiety, a weakly basic but highly efficient arginine analogue, completely alters the self-assembly properties of the peptide.
Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines.
Koch et al., Ann Arbor, United States. In Rheumatology (oxford), Jan 2016
The aim of this study was to examine the expression of growth-regulated protein-γ (Gro-γ/CXCL3), granulocyte chemotactic protein 2 (GCP-2/CXCL6) and their receptor CXCR2 in endothelial cells (ECs) isolated from SSc skin and determine whether these cells mount an angiogenic response towards pro-angiogenic chemokines.
Altered cerebellum development and impaired motor coordination in mice lacking the Btg1 gene: Involvement of cyclin D1.
Tirone et al., Roma, Italy. In Dev Biol, Jan 2016
We previously showed that the Btg family gene, Tis21/Btg2, is required for normal GCP migration.
Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of cisplatin-based highly emetogenic chemotherapy in patients with cancer: two randomised, active-controlled, double-blind, phase 3 trials.
Navari et al., Johannesburg, South Africa. In Lancet Oncol, Sep 2015
526 patients in HEC-1 (264 rolapitant and 262 active control) and 544 in HEC-2 (271 rolapitant and 273 active control) received at least one dose of study drug at a GCP-compliant site and were included in the modified intention-to-treat population.
Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of moderately emetogenic chemotherapy or anthracycline and cyclophosphamide regimens in patients with cancer: a randomised, active-controlled, double-blind, phase 3 trial.
Schnadig et al., Memphis, United States. In Lancet Oncol, Sep 2015
666 patients in each group received at least one dose of study drug at a GCP-compliant site and were included in the modified intention-to-treat population.
Association of Fc gamma-receptors IIa, IIIa, and IIIb genetic polymorphism with susceptibility to chronic periodontitis in South Indian population.
Hans et al., Gurgaon, India. In Contemp Clin Dent, Sep 2015
The aim of the present study is to determine whether specific FcγRIIa, FcγRIIIa, and FcγRIIIb alleles and/or genotypes are associated with risk for susceptibility to generalized chronic periodontitis (GCP) in South Indian population.
LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration.
Gao et al., Jinan, China. In Sci Rep, 2014
Thus, LKB1 deficiency in the LKB1(Atoh1) CKO mice enhanced Shh signalling, leading to the excessive GCP proliferation and the formation of extra lobules.
Efficient Methods for the Quantum Chemical Treatment of Protein Structures: The Effects of London-Dispersion and Basis-Set Incompleteness on Peptide and Water-Cluster Geometries.
Reimers et al., Sydney, Australia. In J Chem Theory Comput, 2013
We recommend usage of large basis sets such as cc-pVTZ whenever possible to reduce any BSSE effects and, if this is not possible, to use Grimme's gCP correction to account for BSSE when small basis sets are used.
[Erythropoietin in plastic surgery].
Machens et al., München, Germany. In Handchir Mikrochir Plast Chir, 2013
Scientific investigations of EPO in the field of plastic surgery included: free and local flaps, nerve regeneration, wound healing enhancement after dermal thermal injuries and in chronic wounds.Acute evidence for the clinical use of EPO in the field of plastic surgery is still not satisfactory, due to the insufficient number of Good Clinical Practice (GCP)-conform clinical trials.
A novel missense mutation in both OPN1LW and OPN1MW cone opsin genes causes X-linked cone dystrophy (XLCOD5).
Hardcastle et al., London, United Kingdom. In Adv Exp Med Biol, 2011
Missense mutatin in both OPN1LW and OPN1MW cause X-linked cone dystrophy.
The role of glutamate in diabetic and in chemotherapy induced peripheral neuropathies and its regulation by glutamate carboxypeptidase II.
Ceresa et al., Monza, Italy. In Curr Med Chem, 2011
Among them, glutamate carboxypeptidase II (GCP II) inhibition demonstrated promising results in different models of peripheral nerve damage, including diabetic and toxic neuropathies.
NAAG, NMDA receptor and psychosis.
Coyle et al., Ottawa, Canada. In Curr Med Chem, 2011
It is cleaved by a specific peptidase located on astrocytes, glutamate carboxypeptidase type II (GCP-II), to N-acetylaspartate (NAA) and glutamate.
The role of glutamate signaling in pain processes and its regulation by GCP II inhibition.
Slusher et al., Baltimore, United States. In Curr Med Chem, 2011
Glutamate is the predominant excitatory neurotransmitter used by primary afferent synapses and neurons in the spinal cord dorsal horn.
Clinical utility gene card for: blue cone monochromatism.
Hamel et al., Tübingen, Germany. In Eur J Hum Genet, 2011
Genomic rearrangements in the affected genes cause blue cone monochromatism.
Variable retinal phenotypes caused by mutations in the X-linked photopigment gene array.
Sharon et al., Jerusalem, Israel. In Invest Ophthalmol Vis Sci, 2010
Novel and known mutations affecting the L-M opsin gene array were identified in families with X-linked cone-dominated phenotypes.
X-linked cone dystrophy caused by mutation of the red and green cone opsins.
Hardcastle et al., London, United Kingdom. In Am J Hum Genet, 2010
Mutations in the LW/MW cone opsin gene array can, therefore, lead to a spectrum of disease, ranging from color blindness to progressive cone dystrophy (XLCOD5).
A novel middle-wavelength opsin (M-opsin) null-mutation in the retinal cone dysfunction rat.
Zhang et al., Xi'an, China. In Exp Eye Res, 2010
The deficiency in vision of the Opn1mw rat is similar to the color vision defects that occur in humans with a color vision defect but without recessive retinal degeneration.
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.
Gulino et al., Roma, Italy. In Nat Cell Biol, 2006
Here, we identify Numb as a Hedgehog-pathway inhibitor that is downregulated in early GCPs and GCP-derived cancer cells.
GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.
Stearns et al., Stanford, United States. In Nat Cell Biol, 2006
Here, we show that the GCP-WD protein (originally named NEDD1) is the orthologue of the Drosophila Dgrip71WD protein, and is a subunit of the human gammaTuRC.
Application of Novel Therapeutic Agents for CNS Injury: NAAG Peptidase Inhibitors
Lyeth, Boca Raton, United States. In Unknown Journal, 0001
However, NAAG is short-lived in the synapse because of its rapid catabolism by NAAG peptidases (glutamate carboxypeptidase II [GCP-II] and GCP-III), which diminishes the beneficial effects of NAAG.
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