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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Gastrulation brain homeobox 2

Top mentioned proteins: Otx2, gbx1, V1a, en-1, CAN
Papers on Gbx2
Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer.
Imkamp et al., Hannover, Germany. In Anticancer Res, Oct 2015
RESULTS: The following genes appeared to be possibly related to the metastatic potential of the tumor: ELOVL fatty acid elongase 7 (ELOVL7), enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), gastrulation brain homeobox 2 (GBX2), golgi membrane protein 1 (GOLM1), homeobox C6 (HOXC6), minichromosome maintenance complex component 6 (MCM6), marker of proliferation Ki-67 (MKI67), mucin 1, cell surface associated (MUC1), MYC binding protein 2, E3 ubiquitin protein ligase (MYCBP2), somatostatin receptor 1 (SSTR1), topoisomerase (DNA) II alpha 170 kDa (TOP2A) and exportin 6 (XPO6).
Pig Induced Pluripotent Stem Cell-Derived Neural Rosettes Developmentally Mimic Human Pluripotent Stem Cell Neural Differentiation.
Stice et al., Athens, United States. In Stem Cells Dev, Sep 2015
These cells expressed anterior central nervous system fate markers OTX2 and GBX2 through at least seven passages, and responded to retinoic acid, promoting a more posterior fate (HOXB4+, OTX2-, and GBX2-).
Identification of Pax3 and Zic1 targets in the developing neural crest.
Saint-Jeannet et al., New York City, United States. In Dev Biol, 2014
Among the targets identified we found several well-characterized NC-specific genes, including snail2, foxd3, gbx2, twist, sox8 and sox9, which validate our approach.
Cerebellar development in the absence of Gbx function in zebrafish.
Moens et al., Seattle, United States. In Dev Biol, 2014
The MHB forms at the expression boundary of Otx2 and Gbx2, mutually repressive homeodomain transcription factors expressed in the midbrain/forebrain and anterior hindbrain, respectively.
Validation of nucleolar protein 4 as a novel methylated tumor suppressor gene in head and neck cancer.
Califano et al., İstanbul, Turkey. In Oncol Rep, 2014
In the present study, we assessed the association of epigenetic alterations of a panel of 12 genes [nucleolar protein 4 (NOL4), iroquois homeobox 1 (IRX1), SLC5A8, LRRC3B, FUSSEL18, EBF3, GBX2, HMX2, SEPT9, ALX3, SOCS3 and LHX6] with head and neck squamous cell carcinoma (HNSCC) via a candidate gene approach.
Real-time PCR quantification of gene expression in embryonic mouse tissue.
Waters et al., Columbia, United States. In Methods Mol Biol, 2013
The Gbx family of transcription factors consists of two closely related proteins GBX1 and GBX2.
Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner.
Yamasu et al., Saitama, Japan. In Mech Dev, 2013
To uncover the details of Gbx functions, we first examined the dose dependency of its effects on brain formation in zebrafish and found that high-dose gbx2 mRNA injection affected the entire forebrain and midbrain, whereas low-dose mRNA specifically disrupted the isthmic folding at the midbrain-hindbrain boundary (MHB) but only weakly affected the expression of genes involved in MHB specification.
Impact of LIF (leukemia inhibitory factor) expression in malignant melanoma.
Bosserhoff et al., Regensburg, Germany. In Exp Mol Pathol, 2013
Ancillary to BMP4 and BMP7, classical stem cell proteins, e.g., SOX2, NANOG, OCT3/4 and GBX2, are regulated by LIF.
Comparative gene expression profiling in human-induced pluripotent stem cell--derived cardiocytes and human and cynomolgus heart tissue.
Engle et al., United States. In Toxicol Sci, 2013
GATA4, and GATA6) and lack the expression of stem cell markers (FOXD3, GBX2, NANOG, POU5F1, SOX2, and ZFP42).
Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.
Cho et al., Suwŏn, South Korea. In Cell Death Dis, 2012
Chromatin immunoprecipitation studies showed that menin directly associated with the GBX2 promoter and menin-dependent recruitment of SUV39H1 was essential for chromatin remodeling and transcriptional regulation.
Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors.
Aizawa et al., Kōbe, Japan. In Mol Cell Biol, 2012
the Gbx2 homeodomain recognizes the target TAATTA in the FM enhancer, and Gbx2 associates with the FM enhancer in the hindbrain
Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.
Waters et al., Columbia, United States. In Plos One, 2011
Gbx2 encodes a DNA-binding transcription factor that plays pivotal roles during embryogenesis.
CpG island methylation profiling in human salivary gland adenoid cystic carcinoma.
El-Naggar et al., Jackson, United States. In Cancer, 2011
Hypermethylation was identified near genes encoding predominantly transcription factors (EN1, FOXE1, GBX2, FOXL1, TBX4, MEIS1, LBX2, NR2F2, POU3F3, IRX3, TFAP2C, NKX2-4, PITX1, NKX2-5), and 13 genes with different functions (MT1H, EPHX3, AQPEP, BCL2L11, SLC35D3, S1PR5, PNLIPRP1, CLIC6, RASAL, XRN2, GSTM5, FNDC1, INSRR).
Evolutionarily conserved function of Gbx2 in anterior hindbrain development.
Waters et al., Columbia, United States. In Dev Dyn, 2011
gbx2/Gbx2 has an evolutionarily conserved role in anterior hindbrain development.
Gbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary.
Li et al., Farmington, United States. In Development, 2011
findings reveal the distinct function of Gbx2 and Fgf8 in a stepwise process in the development of the compartment boundary at the midbrain-hindbrain border
The lineage contribution and role of Gbx2 in spinal cord development.
Zervas et al., Providence, United States. In Plos One, 2010
long-term lineage analysis reveals that the presence and timing of Gbx2 expression in interneuron progenitors results in the differential contribution to subtypes of terminally differentiated interneurons in the adult spinal cord
The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum.
Li et al., Farmington, United States. In J Neurosci, 2010
Gbx2 is required for the development of striatal cholinergic interneurons, perhaps by regulating tangential migration of the striatal cholinergic precursors.
Inherent differential propensity of dental pulp stem cells derived from human deciduous and permanent teeth.
Abu Kasim et al., Kuala Lumpur, Malaysia. In J Endod, 2010
However, DPSCs showed higher expression of neuroectodermal markers PAX6, GBX2, and nestin (fold expression >100).
The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.
Leutz et al., Berlin, Germany. In Cell, 1997
The homeobox gene GBX2 was identified as a target gene of the v-Myb oncoprotein encoded by the avian myeloblastosis virus (AMV).
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