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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase

This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, Smt3, HAD, STAT1
Papers on GBP
Interferon-inducible GTPases in cell autonomous and innate immunity.
Broz et al., Basel, Switzerland. In Cell Microbiol, Feb 2016
Here we discuss recent advances in understanding the function, the targeting and regulation of IRG and GBP proteins during microbial infections.
Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α2δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity.
Chen et al., Beijing, China. In Neurosci Bull, Feb 2016
UNASSIGNED: The α2δ-1 subunit of the voltage-gated Ca(2+) channel (VGCC) is a molecular target of gabapentin (GBP), which has been used as a first-line drug for the relief of neuropathic pain.
Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis.
Xu et al., Guangzhou, China. In J Immunol, Feb 2016
Protein inhibitor of activated STAT (PIAS), whose family members include PIAS1, PIAS2 (PIASx), PIAS3, and PIAS4 (PIASy), play important roles in regulating various cellular events, such as cell survival, migration, and signal transduction in many cell types.
[Variation of long-chain 3-hydroxyacyl-CoA dehydrogenase DNA methylation in placenta of different preeclampsia-like mouse models].
Yi et al., Beijing, China. In Zhonghua Fu Chan Ke Za Zhi, Oct 2015
OBJECTIVE: By detecting the variation of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) DNA methylation in preeclampsia-like mouse models generated by different ways, to explore the roles of multifactor and multiple pathways in preeclampsia pathogenesis on molecular basis.
[Study on the methylation of LCHAD gene promoter region in mitochondria of trophoblast cells incubated with long-chain fatty acids].
Han et al., Beijing, China. In Zhonghua Yi Xue Za Zhi, Sep 2015
OBJECTIVE: To explore the methylation level of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) gene promoter region in mitochondria of trophoblasts incubated with long-chain fatty acids and the time-effect of methylation modification.
Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies.
Amaral et al., Porto Alegre, Brazil. In Biosci Rep, 2014
We will briefly summarize the current knowledge obtained from patients and genetic mouse models with these disorders indicating that disruption of mitochondrial energy, redox and calcium homoeostasis is involved in the pathophysiology of the tissue damage in the more common FAOD, including medium-chain acyl-CoA dehydrogenase (MCAD), long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) and very long-chain acyl-CoA dehydrogenase (VLCAD) deficiencies.
Transcriptomic analysis of Camellia ptilophylla and identification of genes associated with flavonoid and caffeine biosynthesis.
Hang et al., Nanjing, China. In Genet Mol Res, 2014
The quality of the raw data was assessed to yield 70,227,953 cleaned reads totaling 7.09 Gbp, which were assembled de novo into 56,695 unique transcripts and then clustered into 44,749 unigenes.
Lead modulation of macrophages causes multiorgan detrimental health effects.
Lawrence et al., Albany, United States. In J Biochem Mol Toxicol, 2014
More recent evidence from mouse studies indicates that even low, environmentally relevant, blood concentrations of Pb result in increased phagocytosis of erythrocytes and decreased expression of interferon-gamma-inducible GTPases, p65-GBP, and p47-IRG, which are necessary for intracellular pathogen killing.
Chemistry of natural glycan microarrays.
Smith et al., Atlanta, United States. In Curr Opin Chem Biol, 2014
Glycan presentation on microarrays may affect glycan binding by GBPs, often through multivalent recognition by the GBP.
Using glycan microarrays to understand immunity.
Stowell et al., Atlanta, United States. In Curr Opin Chem Biol, 2014
While early studies sought to understand GBP glycan binding specificity, limitations in the availability of test glycans made it difficult to elucidate a detailed understanding of glycan recognition.
A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.
Takeda et al., Suita, Japan. In Immunity, 2012
Stimulation of innate immune cells by IFN-γ upregulates ∼2,000 effector genes such as immunity-related GTPases including p65 guanylate-binding protein (Gbp) family genes.
Identification of the up-regulation of TP-alpha, collagen alpha-1(VI) chain, and S100A9 in esophageal squamous cell carcinoma by a proteomic method.
Meng et al., Luoyang, China. In J Proteomics, 2012
TP-alpha, collagen alpha-1(VI) chain and S100A9 are potential biomarkers of esophageal squamous cell carcinoma, and may play an important role in tumorigenesis and development of ESCC.
SUMOylation of Blimp-1 is critical for plasma cell differentiation.
Lin et al., Taipei, Taiwan. In Embo Rep, 2012
PIAS1 modifies covalent modification of Blimp-1 by SUMO-1 at lysine 816.
PIAS1 is increased in human prostate cancer and enhances proliferation through inhibition of p21.
Culig et al., Innsbruck, Austria. In Am J Pathol, 2012
The data reveal an important new role for PIAS1 in the regulation of cell proliferation in prostate cancer.
PIAS1 is a GATA4 SUMO ligase that regulates GATA4-dependent intestinal promoters independent of SUMO ligase activity and GATA4 sumoylation.
Berger et al., Houston, United States. In Plos One, 2011
PIAS1 is a SUMO ligase for GATA4 that differentially regulates GATA4 transcriptional activity independent of SUMO ligase activity and GATA4 sumoylation.
A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.
MacMicking et al., New Haven, United States. In Science, 2011
Here, we examined a complete mouse 65-kilodalton (kD) guanylate-binding protein (Gbp) gene family as part of a 43-member IFN-γ-inducible guanosine triphosphatase (GTPase) superfamily in mouse and human genomes.
HADHA is a potential predictor of response to platinum-based chemotherapy for lung cancer.
Sato et al., Japan. In Asian Pac J Cancer Prev, 2010
High HADHA protein expression is associated with response to platinum-based chemotherapy for lung cancer.
The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression.
Shuai et al., Los Angeles, United States. In Science, 2010
PIAS1 restricts the differentiation of natural T(reg) cells by maintaining a repressive chromatin state of the Foxp3 promoter.
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.
Jackson et al., Cambridge, United Kingdom. In Nature, 2010
Here, we show that SUMO1, SUMO2 and SUMO3 accumulate at DSB sites in mammalian cells, with SUMO1 and SUMO2/3 accrual requiring the E3 ligase enzymes PIAS4 and PIAS1.
Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.
Shuai et al., Los Angeles, United States. In Cell, 2007
The results identify a signaling pathway in which proinflammatory stimuli activate the IKKalpha-mediated sumoylation-dependent phosphorylation of PIAS1 for the immediate repression of inflammatory gene activation.
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