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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Gastrin, gastrin-17, G17
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cholecystokinin, ACID, HAD, Bombesin, somatostatin
Papers using Gastrin antibodies
Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor
Varro A. et al., In American Journal of Physiology - Gastrointestinal and Liver Physiology, 2005
... wortmannin were all from Calbiochem (Nottingham, UK), YM022 was from Tocris Bioscience (Bristol, UK), and gastrin-17 was from Bachem (St ...
Papers on Gastrin
Oxyntic gastric atrophy in Helicobacter pylori gastritis is distinct from autoimmune gastritis.
Malfertheiner et al., Magdeburg, Germany. In J Clin Pathol, Feb 2016
Serum gastrin-17 (G17), pepsinogen (PG) I, PGII and antibodies against H. pylori and cytotoxin-associated gene A protein were determined in all patients.
Synthesis, antiviral activity, 3D-QSAR, and interaction mechanisms study of novel malonate derivatives containing quinazolin-4(3H)-one moiety.
Song et al., Guiyang, China. In Bioorg Med Chem Lett, Feb 2016
Notably, compounds g15, g16, g17, and g18 exhibited excellent curative activities in vivo against CMV, with 50% effective concentration (EC50) values of 208.36, 153.78, 181.47, and 164.72μg/mL, respectively, which were better than that of Ningnanmycin (256.35μg/mL) and Ribavirin (523.34μg/mL).
Stomach-specific Biomarkers (GastroPanel) Can Predict the Development of Gastric Cancer in a Caucasian Population: A Longitudinal Nested Case-Control Study in Siberia.
Voevoda et al., Novosibirsk, Russia. In Anticancer Res, Jan 2016
A panel of stomach-specific serum biomarkers: pepsinogen (PG) I, pepsinogen (PG) II, gastrin-17 (G-17), and IgG antibodies to H. pylori (HP-Ab) detects the extent and grade of AG.
New radiopharmaceutical agents for the treatment of castration-resistant prostate cancer.
Chinol et al., Milano, Italy. In Q J Nucl Med Mol Imaging, Dec 2015
Gastrin-releasing peptide receptors (GRPr) are also highly overexpressed in PCa.
In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies.
de Jong et al., Rotterdam, Netherlands. In Theranostics, Dec 2015
Gastrin-releasing peptide receptor (GRPR) targeting peptides are promising probes for a theranostic approach for PCa overexpressing GRPR.
Wehbi et al., Atlanta, United States. In Gastroenterol Rep (oxf), Aug 2015
Gastrin is an important hormone of the digestive system, which assists gastric acid secretion.
Expression of CCK Receptors in Carcinoma Gallbladder and Cholelithiasis: A Pilot Study.
Goel et al., Imphāl, India. In J Clin Diagn Res, Jul 2015
BACKGROUND: Gastrin and cholecystokinin (CCK) receptors are trophic for various gastrointestinal malignancies.
Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the Stomach.
Fossmark et al., Trondheim, Norway. In Dig Dis Sci, Jun 2015
Gastric cancer occurs almost exclusively in patients with gastritis.
Peptidyl hormones of endocrine cells origin in the gut--their discovery and physiological relevance.
Dembinski et al., Kraków, Poland. In J Physiol Pharmacol, Feb 2015
Gastrin was discovered in 1905; whereas cholecystokinin in 1928.
GRPR-targeted Protein Contrast Agents for Molecular Imaging of Receptor Expression in Cancers by MRI.
Yang et al., Athens, United States. In Sci Rep, 2014
Gastrin-releasing peptide receptor (GRPR) is differentially expressed on the surfaces of various diseased cells, including prostate and lung cancer.
Gastrin-releasing peptide receptor signaling in the integration of stress and memory.
Merali et al., Porto Alegre, Brazil. In Neurobiol Learn Mem, 2014
Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin.
Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF).
Patel et al., Melbourne, Australia. In Endocrinology, 2012
hypoxia up-regulates the gastrin gene in AGS cells by HIF-independent mechanisms
A new biomarker that predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps.
Seva et al., Toulouse, France. In Cancer Prev Res (phila), 2012
progastrin predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps
Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma.
Morii et al., Taiwan. In J Zhejiang Univ Sci B, 2012
a high level of PBX2 is a poor prognosticator for disease-free survival and overall survival in gingival squamous cell carcinoma
Immunohistochemical identification and localisation of gastrin and somatostatin in endocrine cells of human pyloric gastric mucosa.
Lewandowska et al., Białystok, Poland. In Folia Morphol (warsz), 2012
Investigation of the healthy human pylorus shows characteristic distribution of cells that react with antisera to gastrin and somatostatin.
Serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy.
Wasilewska et al., Białystok, Poland. In Adv Med Sci, 2010
analysis of serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy
Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer.
Caplin et al., London, United Kingdom. In J Clin Oncol, 2002
Gastrin acts as a growth factor for pancreatic cancer.
Autoantibody to the gastrin receptor in pernicious anemia.
Toh et al., In N Engl J Med, 1985
We examined serum IgG fractions from 20 patients with pernicious anemia and 25 control subjects for their capacity to inhibit binding of [125I]15-leu human gastrin-17 to parietal-cell-enriched gastric mucosal cells.
Phosphorylation of gastrin-17 by epidermal growth factor-stimulated tyrosine kinase.
Monckton et al., In Nature, 1983
Such a sequence is also found adjacent to the phosphotyrosine of middle T antigen, and in the homologous region of the hormone gastrin, adjacent to a tyrosine which is sulphated in approximately half the gastrin isolated from gastric mucosa.
Evidence for coexistence of dopamine and CCK in meso-limbic neurones.
Markey et al., In Nature, 1980
In the CNS, true gastrin molecules, gastrin-17 and gastrin-34 have been located only in the neurohypophysis, hypothalamus and occasionally in the medulla oblongata (unpublished results).
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