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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Gastrin-releasing peptide receptor

gastrin-releasing peptide receptor, GRPR, bombesin receptor
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Bombesin, Gastrin, ACID, CAN, HAD
Papers on gastrin-releasing peptide receptor
Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells.
Roesler et al., Porto Alegre, Brazil. In Mol Neurobiol, Feb 2016
The activation of gastrin-releasing peptide receptors (GRPR) stimulates GBM cell proliferation, whereas GRPR antagonists induce antiproliferative effects in in vitro and in vivo experimental models of GBM.
A Stress-related Peptide Bombesin Centrally Induces Frequent Urination through Brain Bombesin Receptor Types 1 and 2 in the Rat.
Saito et al., Kōchi, Japan. In J Pharmacol Exp Ther, Feb 2016
Bombesin-like peptides and bombesin receptor type 1 and 2 (BB1/BB2) in the brain have been implicated in the mediation/integration of stress responses.
Novel bispecific PSMA/GRPr targeting radioligands with optimized pharmacokinetics for improved PET imaging of prostate cancer.
Kopka et al., In Bioconjug Chem, Feb 2016
UNASSIGNED: A new series of bispecific radioligands targeting the prostate-specific membrane antigen (PSMA) and the gastrin releasing peptide receptor (GRPr), both expressed on prostate cancer cells, were developed.
Molecular Imaging of Prostate Cancer.
Vargas et al., Zürich, Switzerland. In Radiographics, Jan 2016
The androgen receptor, prostate-specific membrane antigen, and gastrin-releasing peptide receptor (ie, bombesin) are overexpressed in prostate cancer and can be targeted by specific radiolabeled imaging probes.
In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies.
de Jong et al., Rotterdam, Netherlands. In Theranostics, Dec 2015
Gastrin-releasing peptide receptor (GRPR) targeting peptides are promising probes for a theranostic approach for PCa overexpressing GRPR.
New radiopharmaceutical agents for the treatment of castration-resistant prostate cancer.
Chinol et al., Milano, Italy. In Q J Nucl Med Mol Imaging, Dec 2015
Gastrin-releasing peptide receptors (GRPr) are also highly overexpressed in PCa.
Gate control of mechanical itch by a subpopulation of spinal cord interneurons.
Goulding et al., Los Angeles, United States. In Science, Nov 2015
This chronic itch state is histamine-independent and is transmitted independently of neurons that express the gastrin-releasing peptide receptor.
Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications.
Castellone et al., Napoli, Italy. In Curr Drug Targets, Nov 2015
In this review we will discuss the molecular signalling, the expression and the functional role of BN/GRP-GRPR in different cancer models and will focus on the available strategies to target BN/GRP-GRPR in cancer treatment as well as in tumour diagnosis and follow up.
Positron Emission Tomography in Prostate Cancer: Summary of Systematic Reviews and Meta-Analysis.
Jadvar, Los Angeles, United States. In Tomography, Sep 2015
Future systematic reviews will be needed for other emerging radiotracers such as those based on prostate specific membrane antigen and gastrin-releasing peptide receptor.
Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
Yosipovitch et al., Philadelphia, United States. In Clin Rev Allergy Immunol, Jun 2015
Various receptors (TRPA1, TRPV1, PAR2, gastrin-releasing peptide receptor (GRPR), Mas-related G proteins), secreted molecules (histamine, nerve growth factor (NGF), substance P (SP), proteases), and cytokines/chemokines (thymic stromal lymphopoietin (TSLP), IL-2, IL-4, IL-13, and IL-31) are implicated as mediators of chronic pruritus.
Bombesin receptor subtype 3 as a potential target for obesity and diabetes.
Jensen et al., Madrid, Spain. In Expert Opin Ther Targets, 2014
It involves recognition of the central role the G-protein-coupled receptor, bombesin receptor subtype 3 (BRS-3) plays in energy/glucose metabolism.
Expression of gastrin-releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility.
Smith et al., Cambridge, United Kingdom. In J Physiol, 2012
Tonic stretch of human myometrium increases contractility and stimulates the expression of a known smooth muscle stimulatory agonist, GRP. GRP receptor antagonists attenuate the effect of stretch.
Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils.
Bonorino et al., Porto Alegre, Brazil. In Proc Natl Acad Sci U S A, 2012
Gastrin-releasing peptide receptor mediates chemotaxis in neutrophils, and may be an alternative chemotactic receptor playing a role in the pathogenesis of inflammatory disorders.
Immunohistochemical analysis of gastrin-releasing peptide receptor (GRPR) and possible regulation by estrogen receptor βcx in human prostate carcinoma.
Sasano et al., Sendai, Japan. In Neoplasma, 2011
High GRPR is associated with prostate carcinoma.
Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study.
Siegfried et al., Pittsburgh, United States. In Respir Res, 2011
Bronchial gastrin-releasing peptide receptor expression was significantly associated with lung cancer in a multivariable logistic regression model adjusted for age, sex, smoking status and pulmonary function. Lung cancer risk was not modified by sex.
Murine GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex.
Shumyatsky et al., United States. In Plos One, 2011
GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex
Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.
Chen et al., Saint Louis, United States. In Cell, 2011
The data suggest that opioid-induced itch is an active process concomitant with but independent of opioid analgesia, occurring via the unidirectional cross-activation of GRPR signaling by MOR1D heterodimerization
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Reitman et al., Rahway, United States. In Cell Metab, 2010
Bombesin receptor subtype 3 (BRS-3) is a G protein coupled receptor whose natural ligand is unknown.
Cellular basis of itch sensation.
Chen et al., Saint Louis, United States. In Science, 2009
Although our previous study suggested that gastrin-releasing peptide receptor (GRPR) is an itch-specific gene in the spinal cord, a long-standing question of whether there are separate neuronal pathways for itch and pain remains unsettled.
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.
Benya et al., Bethesda, United States. In Pharmacol Rev, 2008
The mammalian bombesin receptor family comprises three G protein-coupled heptahelical receptors: the neuromedin B (NMB) receptor (BB(1)), the gastrin-releasing peptide (GRP) receptor (BB(2)), and the orphan receptor bombesin receptor subtype 3 (BRS-3) (BB(3)).
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